Abstract: The development of information infrastructures for international trade to improve supply chain visibility and security has gained momentum due to technological advances. An information infrastructure is a shared, open, and evolving assemblage of interlinked information systems providing distinct information technology capabilities. Examples of information infrastructures are the internet, electronic market places and music platforms. Information infrastructures can be highly beneficial as shown by the aforementioned examples, yet often fail to deliver expected benefits. This research focuses on the cultivation of information infrastructures which refers to a softer, less disruptive design approach compared to traditional design approaches in which systems are defined through specified functional requirements within strict boundaries. Drawing on different stakeholder views within a European Union project for international trade, this research provides a taxonomy of twelve cultivation challenges and four engagement reasons one can expect in the design phase of information infrastructures. Organizational theory is used to discuss underlying explanations. The paper concludes that the cultivation of an information infrastructure for international trade could be highly rewarding, yet is a challenging and long-lasting endeavor which requires multi-disciplinary expertise. Practitioners can use the insights provided by this research to increase their understanding of information infrastructure cultivation to ultimately increase adoption rates.

OBJETIVO: O objetivo deste estudo foi comparar os valores de ácido úrico em duas populações chinesas etnicamente diferentes: Uyghur, com alta prevalência de doença hepática gordurosa não alcoólica, e Han, com prevalência mais baixa. SUJEITOS E MÉTODOS: A concentração sérica de ácido úrico e várias características clínicas e testes laboratoriais relevantes para a síndrome metabólica foram determinados em 4.157 indivíduos Uyghur e 6.448 indivíduos Han submetidos a um programa de checkups. O diagnóstico de esteatose hepática foi estabelecido por ultrassom abdominal. RESULTADOS: A prevalência de doença hepática gordurosa não alcoólica foi de 42,3% e 33,3% entre os indivíduos Uyghur e Han, respectivamente. A prevalência correspondente de hiperuricemia foi de 8,8% e 14,7%. A concentração sérica média de ácido úrico em Uyghurs também foi mais baixa do que em Hans (282,75 contra 310,79 µmol/L; p < 0,01). Entretanto, em ambas as populações, a prevalência de doença hepática gordurosa não alcoólica aumentou com a elevação da concentração sérica de ácido úrico, uma tendência mais pronunciada em Uyghurs do que em Hans (OR 3,279 e 3,230, respectivamente). Vários componentes da síndrome metabólica são mais pronunciados em Uyghurs do que em Hans. CONCLUSÕES: A concentração sérica de ácido úrico é um fator de risco independente para a doença hepática gordurosa não alcoólica tanto em Uyghurs quando em Hans, mas outros fatores de risco podem ser mais importantes nas diferenças na prevalência da doença entre esses dois grupos étnicos.

OBJECTIVE: The aim of this study was to compare serum uric acid values in two ethnically distinct Chinese populations: Uyghur, with a high prevalence of nonalcoholic fatty liver disease, and Han, with a lower prevalence. SUBJECTS AND METHODS: Serum uric acid and several clinical features and laboratory tests relevant to the metabolic syndrome were measured in 4,157 Uyghur and 6,448 Han subjects in a health examination program. The diagnosis of hepatic steatosis was established by abdominal ultrasound examination. RESULTS: The prevalence of nonalcoholic fatty liver disease was 42.3% and 33.3% among Uyghur and Han subjects, respectively. The corresponding prevalence of hyperuricemia was 8.8% and 14.7%. The mean concentration of serum uric acid in Uyghurs also was lower than in Hans (282.75 vs. 310.79 µmol/L; p < 0.01). However, in both populations, the prevalence of nonalcoholic fatty liver disease was increased in association with increasing serum uric acid concentrations, a trend that was more pronounced in Uyghur than in Han subjects (OR 3.279 and 3.230, respectively). Several components of the metabolic syndrome were more pronounced in Uyghurs than in Hans. CONCLUSIONS: Serum uric acid is an independent risk factor in nonalcoholic fatty liver disease in both Uyghurs and Hans, but other risk factors may be more important in the differences in prevalence of the disease between the two ethnic groups.

Regulators and actors in international trade are facing a difficult challenge of increasing control and security while at the same time lowering the administrative burden for traders. As a tentative response, the European Commission has introduced the concept of "trusted traders": certified traders that are in control of their business. Trusted traders are entitled to trade facilitations, faster border crossing, and fewer physical inspections. To enable the use of trusted traders, changes are required to the information infrastructure (II) of international trade. This article complements existing works on e-Government interoperability by a theoretically driven approach with theoretical development of the II concept and how II can be modified as additional focus. Following the principles of IS design research, this paper presents a design proposition for the II of international trade. Using theories of II development and change as kernel theory, our proposition presents a redesign of IT, organizational, human, and change and collaboration elements. The design proposition was evaluated and verified with proof of concept installations and a stakeholder value assessment. The paper contributes to the domain of II and how they may be changed to meet new requirements.