The traditional ideological and political education should keep pace with the times, and the physical and health education should highlight its value, and must combine the two. This study investigated on the integration path of mental health education and college students' ideological and political education. A stratified random sampling was conducted on 2021 students of a higher vocational college. The subjects were divided into the control group and the experimental group. The experimental group was given the integrated intervention course of mental health education and ideological and political education of college students, and the control group was given routine teaching. The depression score of the experimental group is significantly lower than that of the control group, and the mental health quality score is higher than that of the control group. CONTRIBUTION: The integration of mental health education and college students' Ideological and political education can effectively improve the level of college students' mental health. This course constantly improves the students' subjective consciousness, subjective ability and subjective personality, and fully reflects the educational effect of the ideological and political education of college students' mental health course. This research provides data which could be utilised by academics in the field of practical theology, especially youth ministry and religious educational studies

ABSTRACT Purpose The present study explored the potential therapeutic role of oleuropein in sepsis-induced heart injury along with the role of GSK-3β/NF-kB signaling pathway. Methods Sepsis-induced myocardial injury was induced by cecal ligation and puncture (CLP) in rats. The cardiac injury was assessed by measuring the levels of cTnI and creatine kinase-MB (CK-MB). Sepsis-induced inflammation was assessed by measuring interleukin-6 (IL-6), IL-10 and HMGB1 levels. The different doses of oleuropein (5, 10, and 20 mg/kg) were given prior to CLP. Oleuropein (20 mg/kg) was administered after 6 hof CLP. The expressions of GSK-3β, p-GSK-3β (Ser9) and nuclear factor-κB (NF-κB) were measured in heart homogenates. Results Cecal ligation and puncture was associated with myocardial injury, an increase in IL-6, a decrease in IL-10 and an increase in HMGB1. Moreover, it decreased the ratio of p-GSK-3β/GSK-3β and increased the expression of p-NF-kB. Pretreatment with oleuropein attenuated CLP-induced myocardial injury and systemic inflammation in a dose-dependent manner. Administration of oleuropein after the onset of CLP also attenuated cardiac injury and inflammation. It also restored CLP-induced changes in the HMGB1 levels, the ratio of p-GSK-3β/GSK-3β and expression of p- NF-kB. Conclusions Oleuropein attenuates sepsis-induced systemic inflammation and myocardial injury by inhibiting NF-kB and GSK-3β signaling.

Abstract The aim of this meta-analysis was to evaluate the efficacy of Traditional Chinese Medicine (TCM) diet therapy in alleviating the toxicity of chemotherapy and radiotherapy in patients with cancer. Searches were conducted in seven databases for relevant studies published from 1, January 2000 to 1 March, 2020. Randomized controlled trials (RCTs) comparing TCM diet with ordinary diet of cancer patients undergoing chemotherapy and(or) radiotherapy were included. The study has been registered on the “PROSPERO” website with registration number of CRD42019131232. A total of sixteen RCTs included 2336 cases were included. TCM diet therapy is superior to ordinary diet in terms of reducing incidence of leukopenia [RR= 0.57; 95% CI (0.47, 0.69); P<0.0001], and nausea and vomiting [RR=0.54, 95% CI= (0.43, 0.70), P= 0.004], increasing hemoglobin [MD=10.04; 95% CI (7.66, 12.41); P<0.0001], improving Karnofsky Performance Status (KPS) [RR= 1.28; 95% CI (1.15, 1.42); P<0.0001], and gaining weight [RR=1.53, 95%CI= (1.38, 1.68), P < 0.0001] in patients with cancer undergoing chemotherapy and(or) radiotherapy. This meta-analysis demonstrated that TCM diet may reduce the toxicity of chemotherapy (and/or radiotherapy).

Previous studies suggested that chromodomain helicase DNA-binding proteins (CHDs), including CHD 1–8, were associated with several human diseases and cancers including lymphoma, liver cancer, colorectal cancer, stomach cancer, etc. To date, little research on CHD 9 in human cancers has been reported. In this study, we assessed the prognostic value of CHD 9 in patients with colorectal cancer (CRC). We screened for CHD 9 expression using immunohistochemical analysis in 87 surgical CRC specimens and found that the expression was upregulated in 81.5% of the cases, while 7.4% were decreased; in the remaining 11.1% of the cases, levels were not altered. Kaplan-Meier analysis showed that patients with high CHD 9 expression had better prognosis than those with low CHD 9 expression (54.5 vs 32.1%, P=0.034). Subsequently, Cox multi-factor survival regression analysis revealed that expression of CHD 9 protein was an independent predictor for CRC, with a hazard ratio of 0.503 (P=0.028). In addition, we found that CHD 9 expression was positively correlated with MSH2 (rs=0.232, P=0.036). We speculated that CHD9 might be a putative tumor suppressor gene, and could inhibit the development of CRC by participating in DNA repair processes. Our findings suggest that CHD 9 could be a novel prognostic biomarker and a therapeutic target for CRC. Further studies are needed to detect the effect of CHD 9 on cellular function and the expression of mismatch repair genes.

Objective: to investigate the species and breeding density of acaroid mites in stored fruit-derived Chinese medicinal materials in Anhui province. Methods: samples of stored fruit-derived Chinese medicinal materials were collected from 30 herb stores and storehouses in 17 Anhui cities, where the breeding acaroids mites were detected. Results: 20 species of acaroids mites were found in 33 samples, belonging to 15 genus, 5 families of the acaridae respectively, among which T. putrescentiae, A. farinae, C. lactis, and C. berlesei are predominant species. Conclusion: stored fruit-derived Chinese medicinal materials in Anhui areas suffer from serious acaroid mites pollution. Therefore, proactive measures should be taken to control acaroid mites from breeding in an effort to reduce the harm on medicinal materials.

Objetivo: investigar las especies y la densidad de reproducción de ácaros en productos medicinales chinos almacenados derivados de la fruta en la provincia de Anhui. Métodos: muestras de productos medicinales chinos almacenados derivados de la fruta fueron recogidos a partir de 30 herbolarios y almacenes en 17 ciudades de Anhui, donde se detectó la reproducción de ácaros. Resultados: se detectaron 20 especies de ácaros en 33 muestras, pertenecientes a 15 géneros, 5 familias de ácaros respectivamente, entre los cuales T. putrescentiae, A. farinae, C. lactis y C. berlesei son las especies predominantes. Conclusión: los productos medicinales chinos almacenados derivados de la fruta en la zona de Anhui sufren una grave contaminación por ácaros. Por lo tanto, se deben tomar medidas dinámicas para controlar la reproducción de ácaros en un esfuerzo por reducir los daños en los productos medicinales.

Berberine, a constituent of some traditional Chinese medicinal plants, has been reported to have cytotoxicity effects on different human cancer cell lines. There is no available information about the effects and mechanism of action of berberine on human colon cancer cell line HCT-8. In this paper, the cytotoxicity of berberine on HCT-8 cancer cells was investigated by MTT assay, fluorescence microscopy and flow cytometry analysis. Our data revealed that berberine could significantly inhibit the growth of HCT-8 cells in a dose- and time-dependent manner. Morphology of apoptotic cells was studied with acridine orange/ethidium bromide staining. The concentrations of lactate dehydrogenase and both acid and alkaline phosphatases were significantly increased in cell supernatants after berberine treatment, suggesting cell death. Furthermore, flow cytometry analysis showed that berberine could arrest HCT-8 cells at S phase in a time-dependent manner. To further investigate the apoptotic molecular mechanism, reverse transcription-polymerase chain reaction (RT-PCR) and western blotting methods were used. The up-regulated mRNA and/or protein expressions of Fas, FasL, TNF-a, caspase-3 and down-regulation of pro-caspase-3 suggest that the death receptor pathway may be involved in the apoptotic pathway induced by berberine. Decrease of Bcl-2 and increase of Bax in mRNA and/or protein expressions showed that the Bcl-2 family proteins were involved in berberine-induced apoptosis. We also found that berberine-induced apoptosis was associated with an up-regulated expressions of p53 and prohibitin (PHB), and decreased vimentin expression. These results suggest that berberine can suppress cell growth and reduce cell survival by arresting the cell-cycle and by inducing apoptosis of HCT-8 cells.

Automating semantic matching of attributes for the purpose of information integration is challenging, and the dynamics of the Web further exacerbate this problem. Believing that many facets of metadata can contribute to a resolution, we present a framework for multifaceted exploitation of metadata in which we gather information about potential matches from various facets of metadata and combine this information to generate and place confidence values on potential attribute matches. To make the framework apply in the highly dynamic Web environment, we base our process on machine learning when sufficient applicable data is available and base it otherwise on empirically observed rules. Experiments we have conducted are encouraging, showing that when the combination of facets converges as expected, the results are highly reliable.