ABSTRACT Introduction: With the growing importance of physical training over sport training for competition, more research has been conducted. One of the least explored techniques is superisometric aquatic training. Objective: Study the application of super-isometric aquatic training to the physical training of soccer athletes. Methods: A literature review was performed to elaborate an experimental protocol. The experimental method was conducted on 24 university volunteers randomly divided into control and experimental groups. Classical training was conducted for two weeks between the groups, superisometric aquatic training was added only in the experimental group. Through the mathematical-statistical method, a comparative analysis of the research results was elaborated, and the effects of the intervention were discussed. Results: The movement time of the athletes in the experimental training group was reduced by 1.89s. The performance of running, tapping, standing jump, and weightlifting tests is not significantly different from those of the traditional strength training group. Conclusion: The application of superisometric aquatic training in the physical preparation of soccer players increased the overall strength of athletes,and also beneficially influenced specific activities of the sport. It is recommended to analyze the characteristics of the athlete and integrate superisometric training to general strength traispecificcally to the need of each athlete. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

RESUMEN Introducción: Con la creciente importancia de la preparación física en el entrenamiento deportivo para la competición, se ha realizado un número cada vez mayor de investigaciones. Una de las técnicas poco exploradas es el entrenamiento acuático superisométrico. Objetivo: Estudiar la aplicación del entrenamiento acuático superisométrico a la preparación física de los deportistas de fútbol. Métodos: Se realizó una revisión de la literatura para elaborar un protocolo experimental. El método experimental se llevó a cabo con 24 voluntarios universitarios divididos aleatoriamente en grupos de control y experimentales. El entrenamiento clásico se realizó durante quince días entre los grupos, el entrenamiento acuático superisométrico se añadió sólo en el grupo experimental. Mediante el método estadístico matemático se elaboró un análisis comparativo de los resultados de la investigación y se discutieron los efectos de la intervención. Resultados: El tiempo de movimiento de los atletas del grupo de entrenamiento experimental se redujo en 1,89s. El rendimiento de la carrera, el golpeo, el salto de pie y los resultados de las pruebas de levantamiento de pesas no fueron significativamente diferentes de los del grupo de entrenamiento de fuerza tradicional. Conclusión: La aplicación del entrenamiento acuático superisométrico en la preparación física de los jugadores de fútbol aumentó la fuerza general de los atletas, también influyó beneficiosamente en las actividades específicas del deporte. Se recomienda analizar las características del deportista e integrar el entrenamiento superisométrico al entrenamiento de fuerza general de forma específica a la necesidad de cada deportista. Nivel de evidencia II; Estudios terapéuticos -investigación de los resultados del tratamiento.

RESUMO Introdução: Com a crescente importância do treinamento físico sobre o treinamento esportivo para competição, um número cada vez maior de pesquisas vem sendo realizado. Uma das técnicas pouco exploradas é o treinamento aquático superisométrico. Objetivo: Estudar a aplicação do treinamento aquático superisométrico ao treinamento físico de preparo dos atletas de futebol. Métodos: Uma análise da literatura foi efetuada para elaborar um protocolo experimental. O método experimental foi conduzido sobre 24 universitários voluntários divididos aleatoriamente em grupo controle e experimental. O treinamento clássico foi conduzido por duas semanas entre os grupos, o treinamento aquático superisométrico foi adicionado apenas no grupo experimental. Através do método estatístico matemático uma análise comparativa dos resultados da pesquisa foi elaborada e os efeitos da intervenção foram discutidos. Resultados: O tempo de movimento dos atletas no grupo de treinamento experimental foi reduzido em 1,89s. O desempenho de corrida, toque, salto em pé e os resultados dos testes de levantamento de peso não foram significativamente diferentes daqueles do grupo de treinamento de força tradicional. Conclusão: A aplicação do treinamento aquático superisométrico no preparo físico de futebolistas aumentou a força geral dos atletas, também influenciou beneficamente em atividades específicas do esporte. Recomenda-se analisar as características do esportista e integrar o treinamento superisométrico ao treinamento de força geral especificamente à necessidade de cada esportista. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

Abstract We aimed to compare the effects of oxycodone hydrochloride and dezocine on hemodynamics and inflammatory factors in patients receiving gynecological laparoscopic surgery under general anesthesia. A total of 246 patients were divided into group A and B (n=123). Hemorheology indices were recorded 5 min after anesthesia (T0), 1 min after pneumoperitoneum (T1), when position was changed 5 min after pneumoperitoneum (T2), 15 min after pneumoperitoneum (T3), 1 min (T4) and 5 min (T5) after position was restored. Visual analogue scale scores 1, 2, 6, 12, 24 and 48 h after operation were recorded. Postoperative adverse reactions and visceral pain were observed. The expression levels of inflammatory factors were detected by enzyme-linked immunosorbent assay 12 h after operation. Compared with group A, group B had higher heart rate and mean arterial pressure at T2, lower central venous pressure and cardiac output at T1-T3, and higher systemic vascular resistance at T1-T5 (P<0.05). The incidence rate of pain syndrome in group A was lower (P<0.05). Group A had lower tumor necrosis factor-alpha and interleukin-6 expression levels and higher interleukin-10 level than those of group B (P<0.05). For gynecological laparoscopic surgery, oxycodone preemptive analgesia has superior outcomes to those of dezocine.

ABSTRACT Objective: Interstitial cystitis (IC)/bladder pain syndrome (BPS) is a chronic inflammatory disease that can cause bladder pain and accompanying symptoms, such as long-term urinary frequency and urgency. IC/BPS can be ulcerative or non-ulcerative. The aim of this study was to explore the core genes involved in the pathogenesis of ulcerative IC, and thus the potential biomarkers for clinical treatment. Materials and Methods: First, the gene expression dataset GSE11783 was downloaded using the Gene Expression Omnibus (GEO) database and analyzed using the limma package in R to identify differentially expressed genes (DEGs). Then, the Database for Annotation, Visualization and Integrated Discovery (DAVID) was used for Gene Ontology (GO) functional analysis, and the Kyoto Encyclopedia of Genes and Genomes (KEGG) was used for pathway enrichment analysis. Finally, the protein-protein interaction (PPI) network was constructed, and key modules and hub genes were determined using the STRING and Cytoscape software. The resulting key modules were then analyzed for tissue-specific gene expression using BioGPS. Results: A total of 216 up-regulated DEGs and 267 down-regulated genes were identified, and three key modules and nine hub genes were obtained. Conclusion: The core genes (CXCL8, CXCL1, IL6) obtained in this study may be potential biomarkers of interstitial cystitis with guiding significance for clinical treatment.

ABSTRACT At present, most large machinery and vehicle engines are electronically controlled but their electronic control systems are too expensive to be popularised and applied in small gasoline engines with relatively low prices. Therefore, small gasoline engines still use mechanical speed regulators. Mechanical speed regulators not only have the defects of inertia lag, friction resistance, inherent speed regulation and the like, but also have the disadvantage that dynamic performance and steady performance cannot be combined, which is not suitable for the increasingly improved speed regulation performance of gasoline engines. This paper describes the design of an electronically controlled intelligent governor for small gasoline engines. Starting from a low cost, it adopts the idea of “replacing part of the hardware with an intelligent sensing algorithm” and proposes an intelligent sensing algorithm scheme. It combines the “coarse tuning” of MAP and the “fine tuning” of adaptive expert PID. The system is proved experimentally and it not only overcomes the inherent defects of a mechanical governor and realises programmable speed regulation, but it also obtains good dynamic and steady performance, improves the power output of the engine, relieves the trouble of engine travelling and improves the freedom of carburetor matching.

Safeners are an important tool used to ensure the safe using of herbicide. The objective of this paper was to investigate the protective effect of four 3-dichloroacetyl oxazolidine safeners (3-dichloroacetyl-2,2-dimethyl-1,3-oxazolidine [R-28725], racemate of 3-dichloroacetyl-2,2-dimethyl-4- ethyl-1,3-oxazolidine, and its two chiral stereoisomers) in reducing the injury caused by imazethapyr. Physiological and biochemical tests were conducted under laboratory condition, by using seed treatment with safeners and soil treatment with imazethapyr, respectively. The interaction of two safeners (R-28725 and R-stereoisomer) and imazethapyr reduced the injury of maize significantly, and also increased glutathione content, activity of glutathione S-transferases, and activity of acetolactate synthase in maize. When induced by R-stereoisomer, the GSH content in root and in shoot increased 100.7% and 73.6%, respectively. When induced by R-28725, the GST activity in vivo increased threefold and the GST activity in vitro more than doubled. The kinetic parameter Vmax of GST in the maize treated with R-28725 and R-stereoisomer increased by 102.2% and 81.9%, respectively, compared with the control. The results also showed that R-28725 and R-stereoisomer induced glutathione S-transferases affinity for the substrate of conjugation reaction significantly.

Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorder (EBV+T/NK-LPD) is a continuous spectrum of diseases that share a common feature observed in T cells and NK cells: Excessive lymphoid proliferation. This disease is rare in adults and predominantly affects children with high mortality. Herein, we present a case of EBV+T-LPD that occurred in an adult with clinical manifestations of hepatic dysfunction and megalosplenia. The patient received a splenectomy at a local hospital for the treatment of megalosplenia. Before surgery, she exhibited mild hepatomegaly and normal liver function. However, after the operation, abdominal computed tomography (CT) showed obvious hepatomegaly and severely damaged liver function. After a final diagnosis of EBV+T-LPD at our hospital, the patient received combination therapy with antiviral and immunosuppressive agents. At the 4-month follow-up visit, hepatic function was normal and the size of the liver decreased. Because this patient presented with hepatomegaly before the splenectomy and because hepatic dysfunction rapidly progressed after surgery, an early diagnosis of EBV+T-LPD was crucial. Splenectomy may be recommended before liver involvement to reduce negative postoperative effects on the liver.

A new ionic liquid (IL) based micro-extraction method was developed for the spectrophotometry and spectrofluorometry determination of curcumin in curry products. ILs can effectively extract curcumin from aqueous solution which were used instead of large-scale organic solvents to reduce environmental pollution and production cost. Results show that the fluorescence of curcumin is considerably enhanced in 1-hexyl-3-methylimidazolium hexafluorophosphate ([Hmim][PF6]). Under optimized conditions, the absorbance of curcumin is proportional to the concentration of curcumin in the range of 18.4 ng/mL to 494 ng/mL, and the detection limit is 6.1 ng/mL. In addition, the fluorescence intensity of curcumin is proportional to the concentration of curcumin in the range of 0.050 ng/mL to 120.1 ng/mL, and the detection limit is 0.002 ng/mL. Therefore, an efficient spectrophotometry and spectrofluorometry method for the determination of curcumin was established, and the actual concentration in curry products was satisfactorily determined. The content of curcumin in curry sauce were 14.10±0.40 and 14.32±0.37 mg/g when using the spectrophotometry and spectrofluorometry, the content of curcumin in curry powder were 2.50±1.73 and 2.75±1.40 mg/g when using the spectrophotometry and spectrofluorometry.