Abstract Vascular hypo-responsiveness to vasopressors in patients with obstructive jaundice (OJ) is a common anesthetic event, which leads to perioperative complications and increased mortality. The cause of this clinical issue remains unclear. In this study, we estimated the actin cytoskeleton and arterial protein level in the artery of OJ patients by proteomic analysis. Ten patients with OJ due to bile duct diseases or pancreatic head carcinoma were enrolled, while another ten non-jaundice patients with chronic cholecystitis or liver hemangioma as the control group. Vascular reactivity to noradrenaline was measured before anesthesia on the day of surgery. Artery samples in adjacent tissues of removed tumor were collected and evaluated by 2-dimensional electrophoresis. Proteins with differential expression were detected by MALDI-TOF mass spectrometry with immunoblot confirmation. The results confirmed the phenomenon of vascular hypo-reactivity in OJ patients as suppressed aortic response to noradrenaline were existed in these patients. We also found that actin cytoskeleton and several actin-binding proteins were up- or down-regulated in the artery of OJ patients. These proteins changed in OJ patents might be the basic mechanism of vascular hypo-reactivity, further studies to uncover the role of these proteins in OJ is critical for clinical treatment of these patients.

RESUMO Introdução: As lesões no esporte são uma razão importante para interferir no treinamento esportivo e no exercício físico, já que não apenas levam a dor desnecessária do corpo lesado, mas também levam a emoções negativas em atletas. Objetivo: Estudar as características de lesões esportivas de atletas de ginástica aeróbica de alto nível competitivo na China. Métodos: Dados da literatura, questionário de sondagem, entrevistas especializadas, observação de campo, estatísticas matemáticas e acompanhamento fisioterapêutico foram usados. Resultados: Pulsos, tornozelos, cintura e joelhos são as partes lesadas com maior frequência nas atletas de ginástica aeróbica de alto nível competitivo na China. O tipo mais comum é a lesão aguda, porém a lesão crônica (48,18%) não pode ser ignorada. Noventa por cento de atletas de ginástica aeróbica de alto nível competitivo na ativa treinam com lesões, e 10% param de treinar completamente devido às lesões. Conclusões: Atletas devem ficar atentos a suas reservas fiscais e fortalecer seu treino físico. Devem também ficar atentos a auto supervisão, ao seu estado emocional e controlar a quantidade exercícios que praticam. Nível de evidência II; Estudos terapêuticos – investigação de resultados de tratamento.

ABSTRACT Introduction: Sports injury is an important reason to interfere with sports training and physical exercise since it will not only bring unnecessary pain to the injured body, but also bring out negative emotions in athletes. Objective: To study the sports injury characteristics of high level competitive aerobics athletes in China. Methods: Literature data, questionnaire survey, expert interviews, field observation, mathematical statistics and physiotherapy tracking were used. Results: Wrists, ankles, waist and knees were the most frequently injured parts in high level competitive aerobics athletes in China. The main type of injury was acute injury, but chronic injury (48.18%) could not be ignored. Ninety percent of active high-level competitive aerobics athletes train with injuries, and 10 percent of them completely stop training because of injuries. Conclusions: Athletes should pay attention to their physical reserve and strengthen physical training. They must also be attentive to self-supervision, their own subjective feelings, and control the amount of exercise done. Level of evidence II; Therapeutic studies - investigation of treatment results.

RESUMEN Introducción: Las lesiones en el deporte son una razón importante para interferir en el entrenamiento deportivo y en el ejercicio físico, ya que no solo llevan al dolor desnecesario del cuerpo lesionado, sino que llevan a emociones negativas en atletas. Objetivo: Estudiar las características de lesiones deportivas de atletas de gimnasia aeróbica de alto nivel competitivo en China. Métodos: Se utilizaron datos de la literatura, encuestas de sondeo, entrevistas especializadas, observación de campo, estadísticas matemáticas y acompañamiento fisioterapéutico. Resultados: Muñecas, tobillos, cintura y rodillas son las partes lesionadas con mayor frecuencia en las atletas de gimnasia aeróbica de alto nivel competitivo en China. El tipo más común es la lesión aguda, pero la lesión crónica (48,18%) no puede ignorarse. Noventa por ciento de atletas de gimnasia aeróbica de alto nivel competitivo en China entrenan con lesiones, y 10% paran de entrenar completamiento debido a las lesiones. Conclusiones: Atletas deben atentarse a sus reservas fiscales y fortalecer su entrenamiento físico. Deben también atentarse a la autosupervisión, a su estado emocional y controlar la cantidad de ejercicios que practican. Nivel de evidencia II; Estudios terapéuticos – investigación de resultados de tratamiento.

The aim of the current study was to explore the correlation between physical properties of wet masses and pellet quality by using powdered herbal slices as model drugs. Wet masses with 100 formulations were prepared by taking 20 kinds of powdered herbal slices as model drugs, microcrystalline cellulose as pelletization aid and five levels of added water as liquid binder. Physical properties of the wet masses such as hardness, adhesiveness, springiness, cohesiveness, chewiness, and resilience were measured by a texture analyzer. Meanwhile, the moisture retention capacities (MRC) of powdered herbal slices and wet masses were determined. Particles were classified after they were produced during spheronization. Principal component analysis, factor analysis and classification analysis were performed on the data. Wet masses could be classified into three groups by taking Ha as the first classification index and Ha/Sp as the second classification index. The correct rate of the classification was 91.00%. If Ha value of wet masses was greater than 15610 g, pellets of type ① would form, otherwise, pellets of type ② or type ③ would form based on Ha/Sp value. Then a classification plot of wet masses was developed to predict pellet formation of powdered herbal slices. Meanwhile, the probable mechanism of pellets formation during spheronisation was concluded in this study, which provided useful information to improve pellet quality.

OBJECTIVES: Previous studies have not shown any correlation between bile acid metabolism and bone mineral density (BMD) in women with postmenopausal osteoporosis. Thus, the current study evaluated the association between bile acid levels as well as BMD and bone turnover marker levels in this group of women. METHODS: This single-center cross-sectional study included 150 postmenopausal Chinese women. According to BMD, the participants were divided into three groups: osteoporosis group, osteopenia group, and healthy control group. Serum bile acid, fibroblast growth factor 19 (FGF19), and bone turnover biomarker levels were assessed. Moreover, the concentrations of parathyroid hormone, 25-hydroxy vitamin D [25(OH)D], procollagen type I N-peptide (P1NP), and beta-CrossLaps of type I collagen containing cross-linked C-terminal telopeptide (β-CTX) were evaluated. The BMD of the lumbar spine and proximal femur were examined via dual-energy X-ray absorptiometry. RESULTS: The serum total bile acid levels in the osteoporosis and osteopenia groups (5.28±1.56 and 5.31±1.56 umol/L, respectively) were significantly lower than that in the healthy control group (6.33±2.04 umol/L; p=0.002 and 0.018, respectively). Serum bile acid level was positively associated with the BMD of the lumbar spine, femoral neck, and total hip. However, it negatively correlated with β-CTX concentration. Moreover, no correlation was observed between bile acid and P1NP levels, and the levels of the other biomarkers that were measured did not differ between the groups. CONCLUSION: Serum bile acid was positively correlated with BMD and negatively correlated with bone turnover biomarkers reflecting bone absorption in postmenopausal women. Thus, bile acid may play an important role in bone metabolism.