A fast, sensitive, and selective direct injection electrospray tandem mass spectrometry (DI ESI MS/MS) method that is able to quantify ethyl carbamate in commercial sweetened sugar cane spirit is described. The preparation method uses a modified QuEChERS (quick, easy, cheap, effective, rugged, and safe) with potassium carbonate added to sweetened sugar cane spirit to separate the aqueous phase from the ethanol phase. The aqueous phase contains sucrose that suppresses electrospray ionization. Ethyl carbamate supernatant from the ethanol phase is transferred and enriched with 18-crown-6/trifluoroacetic acid additives. The additives sequester metal cations reducing the ionization of sodium and potassium, favoring the detection of ethyl carbamate as sole protonated cations. The method was successfully applied for the quantification of eleven real samples and certified sugar cane spirit demonstrating its applicability for quality control and regulatory analysis. The method showed reliable analytical parameters compared to conventional gas chromatography mass spectrometry (GC-MS) method commonly used for ethyl carbamate analysis. DI-ESI-MS/MS method requires just a fast step sample clean up and presents consistent values for the limit of detection (LOD 48.0 μg L-1) and limit of quantification (LOQ 160.0 μg L-1). Furthermore, the recoveries obtained were close to 100%, with relative standard deviations below 10% of sample certificates.

Este estudo objetivou caracterizar o perfil de morbidade referida por usuários das equipes de saúde da família na macrorregião nordeste de Minas Gerais. Trata-se de um estudo transversal de base populacional, desenvolvido junto às equipes da Estratégia Saúde da Família (ESF), com uso de questionários semiestruturados adaptados para três categorias profissionais das equipes de saúde da família: médicos, enfermeiros e agentes comunitários de saúde (ACS). Utilizou-se a Classificação Internacional da Atenção Primária, segunda edição (CIAP 2), para codificação da morbidade referida. Foram coletadas informações de 17.988 pessoas, em 204 equipes da ESF, sendo 10.855 (60,3%) do sexo feminino; 1.662 (9,2%) questionários foram referentes ao atendimento do médico, 2.530 (14,1%) do enfermeiro e 13.796 (76,7%) corresponderam aos encontros com ACS. Os principais problemas de saúde foram: doenças do aparelho circulatório (especialmente hipertensão), queixas musculoesqueléticas (especialmente as lombalgias) e doenças do aparelho digestório (especialmente as parasitoses intestinais), que juntas responderam por mais de 40% das consultas médicas. As queixas inespecíficas e atendimentos relacionados à saúde da mulher foram prevalentes nos atendimentos de enfermeiros. Os ACS registraram mais as queixas referentes a problemas respiratórios, musculoesqueléticos e cardiovasculares. O perfil de morbidade observado não difere substancialmente de outros estudos, com pequenas diferenças que podem ser atribuídas às particularidades regionais.

This study aimed to characterize the profile of morbidity among users of family health teams in the northeastern macroregion of Minas Gerais, Brazil. This is a cross-sectional population-based study, developed with the teams of the Family Health Strategy (FHS). It was conducted by data collection, using semi-structured questionnaires with specific instruments adjusted for three categories of professional teams of the FHS: physicians, nurses and community health agents (CHA). We used the International Classification of Primary Care, second edition (ICPC-2) to encode morbidity. Information was collected from 17,988 people, and 10,855 (60.3%) were females; 1,662 (9.2%) questionnaires were related to care by the physician; 2,530 (14.1%) were related to care by nurses and 13,796 (76.7%) corresponded to visits by and meetings with the CHA. The main health problems were: circulatory diseases (especially hypertension), musculoskeletal problems (especially back pain) and diseases of the digestive tract (especially intestinal parasites), which accounted for more than 40% of the medical consultations. Nonspecific complaints and visits related to women's health were the most prevalent in the care by nurses. In meetings with CHA, complaints about respiratory, musculoskeletal and cardiovascular diseases were the most pointed. The morbidity profile observed does not differ substantially from the results of other studies. Small differences can be attributed to regional particularities.

Este estudo objetivou caracterizar o perfil de morbidade referida por usuários das equipes de saúde da família na macrorregião nordeste de Minas Gerais. Trata-se de um estudo transversal de base populacional, desenvolvido junto às equipes da Estratégia Saúde da Família (ESF), com uso de questionários semiestruturados adaptados para três categorias profissionais das equipes de saúde da família: médicos, enfermeiros e agentes comunitários de saúde (ACS). Utilizou-se a Classificação Internacional da Atenção Primária, segunda edição (CIAP 2), para codificação da morbidade referida. Foram coletadas informações de 17.988 pessoas, em 204 equipes da ESF, sendo 10.855 (60,3%) do sexo feminino; 1.662 (9,2%) questionários foram referentes ao atendimento do médico, 2.530 (14,1%) do enfermeiro e 13.796 (76,7%) corresponderam aos encontros com ACS. Os principais problemas de saúde foram: doenças do aparelho circulatório (especialmente hipertensão), queixas musculoesqueléticas (especialmente as lombalgias) e doenças do aparelho digestório (especialmente as parasitoses intestinais), que juntas responderam por mais de 40% das consultas médicas. As queixas inespecíficas e atendimentos relacionados à saúde da mulher foram prevalentes nos atendimentos de enfermeiros. Os ACS registraram mais as queixas referentes a problemas respiratórios, musculoesqueléticos e cardiovasculares. O perfil de morbidade observado não difere substancialmente de outros estudos, com pequenas diferenças que podem ser atribuídas às particularidades regionais.

This study aimed to characterize the profile of morbidity among users of family health teams in the northeastern macroregion of Minas Gerais, Brazil. This is a cross-sectional population-based study, developed with the teams of the Family Health Strategy (FHS). It was conducted by data collection, using semi-structured questionnaires with specific instruments adjusted for three categories of professional teams of the FHS: physicians, nurses and community health agents (CHA). We used the International Classification of Primary Care, second edition (ICPC-2) to encode morbidity. Information was collected from 17,988 people, and 10,855 (60.3%) were females; 1,662 (9.2%) questionnaires were related to care by the physician; 2,530 (14.1%) were related to care by nurses and 13,796 (76.7%) corresponded to visits by and meetings with the CHA. The main health problems were: circulatory diseases (especially hypertension), musculoskeletal problems (especially back pain) and diseases of the digestive tract (especially intestinal parasites), which accounted for more than 40% of the medical consultations. Nonspecific complaints and visits related to women's health were the most prevalent in the care by nurses. In meetings with CHA, complaints about respiratory, musculoskeletal and cardiovascular diseases were the most pointed. The morbidity profile observed does not differ substantially from the results of other studies. Small differences can be attributed to regional particularities.