RESUMO A lagoquilascaríase é uma doença zoonótica causada por um parasita nematoide do gênero Lagochilascaris (família Ascarididae), sendo a ingestão de roedores contaminados a principal fonte de infecção. Os principais sinais clínicos são disfagia e presença de nódulos ulcerados em região cervical. O objetivo deste trabalho foi descrever um caso de lagoquilascaríase em um felino doméstico, na cidade de Caxias do Sul/RS. Um felino, macho, sem raça definida, adulto jovem, apresentou letargia, desidratação, fístulas bilaterais em cavidade orofaringe, globo ocular direito com exoftalmia, opacidade de córnea, prolapso de terceira pálpebra e lesão cutânea ulcerada periocular em região superior medial. O diagnóstico foi realizado por meio da visualização e identificação microscópica do parasita Lagochilascaris minor e de exame coproparasitológico com presença de ovos. O tratamento baseou-se no uso de doramectina e de medidas sanitárias. De acordo com a literatura atual, existem poucos relatos de lagoquilascaríase em felinos com apresentação clínica semelhante a este caso, visto que o mais comum consiste na formação de abscesso na região de pescoço. Além disso, é o primeiro caso descrito no município, contribuindo, assim, para a epidemiologia da doença.

ABSTRACT Lagoquilascariasis is a zoonotic disease caused by a nematode parasite of the genus Lagochilascaris (Family Ascarididae), with the ingestion of contaminated rodents being the main source of infection. The main clinical signs are dysphagia and the presence of ulcerated nodules in the cervical region. The objective was to describe a case of lagaroquilascariasis in a domestic cat, in the city of Caxias do Sul / RS. A young adult male feline, without defined breed presented lethargy, dehydration, bilateral fistulas in the oropharynx cavity, right eyeball with exophthalmos, corneal opacity, third eyelid prolapse and periocular ulcerated skin lesion in the upper medial region. The diagnosis was made through the visualization and microscopic identification of the parasite Lagochilascaris minor and coproparasitological examination with the presence of eggs. Treatment was based on the use of doramectin and sanitary measures. According to the current literature, there are few reports of lagoquilascariasis in felines with clinical presentation similar to this case, since the most common is the formation of an abscess in the neck region. Morover, it is the first case described in the municipality, thus contributing to the epidemiology of the disease.

Fusarium species have emerged as one of the more outstanding groups of clinically important filamentous fungi, causing localized and life-threatening invasive infections with high morbidity and mortality. The ability to produce different types of hydrolytic enzymes is thought to be an important virulence mechanism of fungal pathogens and could be associated with the environment of the microorganism. Here, we have measured the production of two distinct lipolytic enzymes, phospholipase and esterase, by sixteen Fusarium isolates recovered from the hospital environment, immunocompromised patients’ blood cultures, foot interdigital space scrapings from immunocompromised patients, and foot interdigital space scrapings from immunocompetent patients (4 isolates each). Fourteen of these 16 isolates were identified asFusarium solani species complex (FSSC) and two were identified as F. oxysporum species complex (FOSC). Some relevant genus characteristics were visualized by light and electron microscopy such as curved and multicelled macroconidia with 3 or 4 septa, microconidia, phialides, and abundant chlamydospores. All Fusarium isolates were able to produce esterase and phospholipase under the experimental conditions. However, a negative correlation was observed between these two enzymes, indicating that a Fusarium isolate with high phospholipase activity has low esterase activity and vice versa. In addition, Fusarium isolated from clinical material produced more phospholipases, while environmental strains produced more esterases. These observations may be correlated with the different types of substrates that these fungi need to degrade during their nutrition processes.