Abstract The present work describes the nutrients and phenolic compounds contained in diverse agroindustrial residues (AIR). The AIR could derive in problems that compromise the nutrition and health of the most vulnerable populations if they are not properly used. Therefore, it is important to create alternatives that contribute to counteract the problem, from food production to the consumer's table. AIR from fruits, vegetables, cereals and oilseeds contain nutrients and phenolic compounds that can be beneficial to health, due to their antioxidant, anti-inflammatory and antidiabetic effects, among others. The AIR could also be used in food development, due to their techno-functional characteristics such as the capability to act as gelling, emulsifying, stabilizing, and thickening agents. Accordingly, a second use of AIR is promising, however, there are still some challenges to be solved, such as process scaling and optimizing its extraction.

Resumen El presente trabajo describe los nutrientes y compuestos fenólicos contenidos en diversos residuos agroindustriales (RAI). Los RAI pueden derivar en problemas que comprometen la alimentación y salud de las poblaciones más vulnerables si no son aprovechados adecuadamente. Por ello es importante crear alternativas que contribuyan a contrarrestar el problema, desde la producción de alimentos hasta la mesa del consumidor. Los RAI de frutas, verduras, cereales y oleaginosas contienen nutrientes y compuestos fenólicos que pueden ser benéficos a la salud debido a sus efectos antioxidantes, antiinflamatorios, antidiabéticos, entre otros. Los RAI podrían también ser aplicados en el desarrollo de alimentos, debido a sus características tecnofuncionales como la capacidad de actuar como agentes gelificantes, emulsificantes, estabilizantes y espesantes. De acuerdo con lo anterior, el empleo de RAI para un segundo uso es prometedor, sin embargo, aún quedan algunos retos por resolver, tales como el escalamiento y la optimización de su extracción.

Resumen: Antecedentes y Objetivos: Parkinsonia praecox ,“palo brea”, es una planta medicinal distribuida en el Desierto de Sonora en México. Sin embargo, existe poca información acerca de la composición química y del potencial biológico de esta planta. Basado en lo anterior, el objetivo del presente estudio fue determinar la composición química y el potencial antioxidante y antiproliferativo de P. praecox. Métodos: Se prepararon extractos metanólicos de tallos (PPS), frutos (PPB) y flores (PPF). La composición química se determinó a través de los métodos de perfil fitoquímico, Folin-Ciocalteu y UPLC-DAD. La actividad antioxidante se evaluó por los métodos DPPH, ABTS, ORAC y FRAP. La actividad antiproliferativa se determinó por el ensayo MTT contra las líneas celulares A549 (cáncer de pulmón de células no pequeñas), MDA-MB-231 (cáncer de mama triple negativo), PC-3 (cáncer de próstata grado IV), HeLa (cáncer de cervix) y L929 (tejido conectivo subcutáneo no canceroso). Resultados: El perfil fitoquímico mostró la presencia de terpenos, compuestos fenólicos, flavonoides, taninos y azúcares en los extractos. PPS presentó la concentración más elevada (p<0.05) de compuestos fenólicos (65.5 mg GAE/g), identificando y cuantificando quercetina (218.86 µg/g). Además, PPS mostró la capacidad más elevada (p<0.05) para estabilizar a los radicales DPPH (IC50: 137 µg/ml), ABTS (39.56 µM TE/g), hidroxilo (ORAC: 1777.78 µM TE/g), y reducir metales (FRAP: 935.6 µM Fe(II)/g). Un comportamiento similar se observó en la actividad antiproliferativa, ya que PPS mostró la citotoxicidad más elevada (p<0.05): A549 (IC50: 341.3 µg/ml), MDA-MB-231 (IC50: 147.3 µg/ml), PC-3 (IC50: 78.8 µg/ml), HeLa (IC50: 121.6 µg/ml) y L929 (IC50: 93.29 µg/ml). Conclusión: Este es el primer estudio donde se reporta el perfil de compuestos bioactivos y el potencial biológico de P. praecox. Los resultados muestran una fuerte asociación entre la actividad antioxidante y antiproliferativa con la presencia de compuestos fenólicos. Esto representa un potencial soporte para el desarrollo de terapias farmacológicas.

Abstract: Background and Aims: Parkinsonia praecox ,“palo brea”, is a medicinal plant distributed in the Mexican Sonoran Desert. However, there is little information about the chemical composition and biological potential of this plant. As a consequence, the objective of the present study was to determine the chemical composition, as well as the antioxidant and antiproliferative activity, of P. praecox. Methods: Methanolic extracts of stems (PPS), berries (PPB) and flowers (PPF) were performed. Chemical composition was determined by phytochemical screening, Folin Ciocalteu and UPLC-DAD methods. Antioxidant activity was determined by DPPH, ABTS, ORAC and FRAP methods. Antiproliferative activity was evaluated by MTT against A549 (non-small-cell lung cancer cells), MDA-MB-231 (triple negative breast cancer), PC-3 (adenocarcinoma prostate cancer grade IV), HeLa (human cervical cancer) and L929 (non-cancerous subcutaneous connective tissue) cell lines. Results: Phytochemical screening showed the presence of terpenes, phenolic compounds, flavonoids, tannins and sugars in the extracts. PPS showed the highest (p<0.05) concentration of phenolic compounds (65.5 mg GAE/g), identifying and quantifying quercetin (218.86 µg/g). Additionally, PPS exhibited the highest capacity (p<0.05) to stabilize the DPPH (IC50: 137 µg/ml), ABTS (39.56 µM TE/g), hydroxyl radicals (ORAC: 1777.78 µM TE/g), and to reduce metals (FRAP: 935.6 µM Fe(II)/g). Similar behavior was observed in antiproliferative activity, since PPS presented the highest cytotoxicity (p<0.05): A549 (IC50: 341.3 µg/ml), MDA-MB-231 (IC50: 147.3 µg/ml), PC-3 (IC50: 78.8 µg/ml), HeLa (IC50: 121.6 µg/ml) and L929 (IC50: 93.29 µg/ml). Conclusion: This is the first research where the bioactive compound profile and the biological potential of P. praecox are reported. The results show the strong association between the antioxidant and the antiproliferative activities with the presence of phenolic compounds. This represents a potential support for the development of pharmacological therapies.

Abstract Quinoa (Chenopodium quinoa Willd) stands out because of its high nutritional value and bioactive compounds, which can benefit human health. Heat treatments can improve the content of these compounds; however, few reports have investigated the behavior of phenolic compounds in quinoa when subjected to in vitro gastrointestinal digestion. This work aimed to evaluate the effect of heat treatments on: (1) Total phenols and flavonoids, individual phenolics, and antioxidant activity of quinoa flour subjected to two different heat processes (boiling and microwaving); (2) Bioaccessibility of total phenols, flavonoids, individual phenolics, and the intestinal recovery of antioxidant activity of cookies made using heat-treated quinoa flours and (3) Consumer opinions of cookies made using heat-treated quinoa flours. The results demonstrated that cookies formulated with microwave-treated quinoa flour had greater bioaccessibility of phenols (647%), flavonoids (98%), ferulic acid (144%), rutin (65%), quercetin (85%), and kaempferol (97%) than cookies made with raw or boiled quinoa. Cookies made with heat-treated quinoa showed better consumer acceptability than those made with uncooked quinoa. Therefore, the microwave treatment of quinoa may be a viable alternative for producing healthier foods.

Abstract The search for foods with biological potential for the prevention of chronic diseases has highlighted sorghum, and numerous studies have been conducted to determine the best processing conditions without compromising the nutritional, functional or sensory qualities. We conducted a review of the scientific literature on the techniques used in sorghum and their effects on phenolic compounds and antioxidant capacity. This review allowed us to conclude that the type and content of phenolic compounds in the different varieties of sorghum must be considered for the selection of adequate technologies that allow the retention of phenolic compounds with improved bioaccessibility and biological potential. The available information has been mostly focused on the content of total phenols and the antioxidant activity of sorghum, while the digestibility, absorption, utilization and excretion of phenolic compounds have been poorly studied. In this regard, there is a clear need for further studies on sorghum with the aim of including sorghum as part of a healthy diet.