RESUMEN Parietaria judaica y Soleirolia soleirolii (Parietariae, Urticaceae) son hierbas perennes originarias del hemisferio norte que habitan ambientes urbanos y periurbanos en diversos países. En este trabajo, se actualiza el registro para P. judaica con nuevas localidades y hábitats en la provincia de Buenos Aires, se hace referencia a los focos de naturalización de S. soleirolii en Argentina, y se establece el estado de invasión para cada especie. Se estudiaron ejemplares de herbario de ambas especies coleccio- nados entre 1989 y 2022 en varias ciudades de la provincia de Buenos Aires y se documentaron los hábitats que ocupan mediante observaciones en las poblaciones naturalizadas. S. soleirolii se halló solamente en ambientes urbanos. Asimismo, se amplió el área de distribución de P. judaica con registros en numerosas ciudades de la provincia de Buenos Aires, en diversos hábitats de sectores urbanos y periurba- nos. Presenta un amplio período de floración y fructificación. Se mencionaron sus probables agentes y vías de dispersión. Se aportaron imágenes ilustrativas de las especies y sus hábitats, mapas de la posición geográfica de las poblaciones halladas en Buenos Aires y, adicionalmente, una clave para diferenciar los géneros de la tribu Parietarieae en Argentina. El estado de invasión de las dos especies en Argentina es diferente. S. soleirolii no es actualmente una especie con alto potencial invasor. Por el contrario, P. judaica presenta una alta presión de propágulos, avanza probablemente por las vías del ferrocarril, por lo tanto, su potencial invasor es alto. Además, su polen es alergógeno.

ABSTRACT Parietaria judaica and Soleirolia soleirolii (Parietariae, Urticaceae) are perennial herbs native to the Northern Hemisphere, inhabiting urban and peri-urban environments in various countries. In this work, the record for P. judaica is updated with the inclu- sion new localities and habitats in the province of Buenos Aires, naturalization areas of S. soleirolii in Argentina are also mentioned, as well as the invasion status for each species is established. Herbarium specimens of both species collected between 1989 and 2022 in different cities of Buenos Aires were studied. The habitats were docu- mented through observations in naturalized populations. S. soleirolii was found only in urban environments, whereas the distribution area of P. judaica expanded to new habitats in both urban and peri-urban sectors of Buenos Aires. The latter species has a long period of flowering and fruiting. This work also mentions its probable agents and pathways of dispersal. Illustrative images of the species and their habitats are provided, together with maps showing the geographic position of the populations, and a key feature is introduced, allowing to differentiate the genera of the Parietarie- ae tribe in Argentina. The invasion status of these species in Argentina is different.S. soleirolii is not currently a species with high invasive potential; on the contrary,P. judaica has a high propagule pressure, and probably advances along the railroad tracks; therefore its invasive potential is high. In addition, its pollen is allergenic.

Summary Background and aims: Zephyranthes bifida (Amaryllidaceae) was recently included as the only polymorphic species of the subgenus Neorhodophiala. Its taxonomic history has not been reviewed, and it is a valuable contribution to elucidate the putative species complex that suggests the considerable morphological variation observed in its wide range of distribution. The present study aims to present the taxonomic history of Z. bifida with the complete list of synonyms, together with some morphological observations. M&M: Original publications, floras and digital databases were consulted. A table was prepared with the complete list of synonyms in which the scientific name, year and reference of the publication, type of taxonomic event and its synonyms were included. Within the framework of morphometric studies carried out with adult individuals from eight populations in the province of Buenos Aires, certain character measurements were found to be novel compared to the descriptions of Z. bifida. Results and conclusions: Forty-nine taxonomic events were recorded. Based on our study, we propose to include two new synonyms for Z. bifida and recognize one name as illegitimate; thereby, it currently is associated to 43 legitimate synonyms, three illegitimate names, and two isonyms without nomenclatural status. Monitoring of cultivated specimens allowed us to observe that the same bulb can generate inflorescences with both spathe types, ruling out the hypothesis that this morphological variation could correspond to different taxa.

Resumen Introducción y objetivos: Zephyranthes bifida (Amaryllidaceae) fue incluida recientemente como única especie polimórfica del subgénero Neorhodophiala. Su historia taxonómica no ha sido reseñada, pudiendo tratarse de un aporte valioso para dilucidar el posible complejo de especies que sugiere la gran variación morfológica observada en su amplio rango de distribución. El presente trabajo tiene como objetivo presentar la historia taxonómica de Z. bifida con la lista completa de sinónimos, junto con algunas observaciones morfológicas. M&M: Se consultaron publicaciones originales, floras y bases de datos digitales. Se elaboró una tabla con la lista completa de sinónimos en la que se incluyó para cada uno, el nombre científico, año y referencia de la publicación, tipo de evento taxonómico y sus sinónimos. En el marco de estudios morfométricos realizados con individuos adultos de ocho poblaciones de la provincia de Buenos Aires, se encontraron ciertas medidas de caracteres que resultaron novedosas al compararlas con las descripciones de Z. bifida. Resultados y conclusiones: Se registraron 49 eventos taxonómicos. A partir del estudio realizado, se propone incluir dos sinónimos nuevos para Z. bifida y reconocer un nombre como ilegítimo, de modo que actualmente se asocia con 43 sinónimos legítimos, tres nombres ilegítimos y dos isónimos sin estatus nomenclatural. El seguimiento de ejemplares cultivados permitió observar que un mismo bulbo puede generar inflorescencias con los dos tipos de espata, descartándose la hipótesis de que esta variación morfológica podría corresponder a taxones diferentes.

Resumen Objetivo: Describir medidas de presión arterial sistólica (PAS), diastólica (PAD) y media (PAM) en recién nacidos sanos de término y pretérmino tardío para establecer parámetros de normalidad. Método: Estudio transversal realizado en el cunero fisiológico del Hospital Español, Ciudad de México. Se incluyeron 551 pacientes recién nacidos sanos. Las tomas de PA fueron realizadas dentro de las primeras 48 horas de vida con método oscilométrico. Posterior a la evaluación de normalidad, se realizó un análisis descriptivo de la población y cálculo de percentiles (25, 50 y 75) específicos para cada semana de gestación. Todos los análisis fueron realizados en STATA v14.2. Resultados: Los recién nacidos de sexo masculino tuvieron un valor medio de PAS de 64.6 mmHg en la semana 35 de gestación, este valor aumentó a 69.8 mmHg en la semana 40. El valor de la PAD fue de 42.6 mmHg en la semana 35 de gestación, disminuyendo a 40.8 mmHg para la semana 40. Los valores medios de PAS en los recién nacidos de sexo femenino fueron de 65.5 mmHg en la semana 35, teniendo un incremento a 73.5 mmHg en la semana 40. El valor de la PAD en la semana 35 de gestación fue 38 mmHg, incrementando a 41.3 mmHg en la semana 40. Conclusiones: Los valores de PA en recién nacidos sanos se modifican con la edad gestacional y el sexo. Estos resultados pueden servir como referencia para otros médicos ubicados en países o ciudades con alturas similares a la Ciudad de México.

Abstract Objective: Describe the measurements of systolic, diastolic and mean blood pressure in healthy term and late preterm newborns to establish normal values. Methods: Cross-sectional study carried out in the nursery of the Hospital Español, located in Mexico City. A sample of 551 healthy newborns were included in the study. Blood pressure (BP) measurements were taken within the first 48 hours of life with the oscillometric method. After the evaluation of normality, a descriptive analysis of the population and calculation of percentiles (25, 50 and 75) specific for each week of gestation was performed. All analyzes were performed in STATA v14.2. Results: Male newborns had a mean SBP value of 64.6 mmHg at week 35 of gestation, this value increased to 69.8 mmHg at week 40; the systolic blood pressure (SBP) value was 42.6 mmHg at week 35 of gestation, which decreased to 40.8 mmHg at week 40. The mean SBP values in female newborns were 65.5 mmHg at week 35, increasing to 73.5 mmHg at week 40; the diastolic blood pressure (DBP) value at week 35 of gestation was 38 mmHg, increasing to 41.3 mmHg at week 40. Conclusions: The BP values in healthy newborns are modified by the gestational age and sex of the patients. These results can serve as a reference for other physicians located in countries or cities with a similar altitude than the one in Mexico City.

Resumen: En este trabajo se menciona por primera vez para la Argentina la presencia deRomulea rosea(L.) Eckl. (Iridaceae, Ixieae), especie sudafricana que ha invadido Australia y otros países. Fue hallada en el Sistema Orográfico de Tandilia, provincia de Buenos Aires. Se presenta la descripción de la especie, sinonimia, usos, distribución geográfica y hábitat, fenología y estado de la invasión. También se provee una clave para distinguir el géneroRomuleade otros géneros de la tribu Ixieae presentes en el país.

Summary: In this work, the presence ofRomulea rosea(L.) Eckl. (Iridaceae, Ixieae), a South African species that has invaded Australia and other countries, is mentioned for the first time for Argentina. It was found in the orographic Tandilia System, Buenos Aires province. A description of the species, synonymy, uses, geographic distribution and habitat, phenology and invasion status are presented. A key to distinguish the genusRomuleafrom other genera of the Ixieae tribe present in the country is also provided.

Resumen Introducción: Los tumores rabdoides son neoplasias malignas de baja prevalencia, con comportamiento agresivo y alta mortalidad. Inicialmente fueron descritos como renales, aunque posteriormente se han descrito tumores con las mismas características histopatológicas e inmunohistoquímicas en otros sitios, principalmente en el sistema nervioso central. Internacionalmente se han descrito pocos casos de localización mediastinal. El objetivo del presente trabajo fue describir el caso de un tumor rabdoide de localización mediastinal. Caso clínico: Se presenta el caso de un paciente de sexo masculino de 8 meses de edad que ingresó al servicio de pediatría con disfonía y estridor laríngeo que progresó a dificultad respiratoria severa. En la tomografía computarizada contrastada de tórax se observó una gran masa homogénea con densidad de tejidos blandos, de bordes lisos y bien definidos, por lo que se sospechó una neoplasia maligna. Debido a la urgencia oncológica compresiva de la vía aérea se inició con un esquema empírico de quimioterapia. Posteriormente se sometió a resección tumoral incompleta por carácter invasor. El reporte de patología mostró morfología compatible con un tumor rabdoide, el cual se corroboró con estudios de inmunohistoquímica y genética. Se administró un esquema de quimioterapia y radioterapia al mediastino. Sin embargo, el paciente falleció a los 3 meses del inicio de tratamiento debido al comportamiento agresivo del tumor. Conclusiones: Los tumores rabdoides son entidades agresivas y malignas de difícil control y con pobre supervivencia. A pesar de que se requiere un diagnóstico precoz y un tratamiento agresivo, no se ha logrado la supervivencia a 5 años mayor al 40%. Es necesario analizar una mayor cantidad de casos para establecer guías específicas de tratamiento.

Abstract Background: Rhabdoid tumors are malignant neoplasms of low prevalence, aggressive behavior, and high mortality. They were initially described as renal tumors, although tumors with the same histopathological and immunohistochemical characteristics have been discovered in other locations, mainly in the central nervous system. Few cases of mediastinal location have been reported internationally. This work aimed to describe the case of a mediastinal rhabdoid tumor. Case report: We describe the case of an 8-month-old male patient admitted to the pediatric department with dysphonia and laryngeal stridor progressing to severe respiratory distress. Contrast-enhanced computed tomography of the thorax showed a large mass with homogeneous soft tissue density, and smooth and well-defined borders, with suspicion of malignant neoplasm. Due to the oncological emergency compressing the airway, empirical chemotherapy was initiated. Subsequently, the patient underwent incomplete tumor resection due to its invasive nature. The pathology report showed morphology compatible with a rhabdoid tumor, which immunohistochemical and genetic studies corroborated. Chemotherapy and radiotherapy to the mediastinum were administered. However, the patient died three months after the initial treatment due to the aggressive behavior of the tumor. Conclusions: Rhabdoid tumors are aggressive and malignant entities difficult to control and have poor survival. Early diagnosis and aggressive treatment are required, although the 5-year survival does not exceed 40%. It is necessary to analyze and report more similar cases to establish specific treatment guidelines.

Abstract ×Butyagrus nabonnandii (Prosch.) Vorster is known as mule palm due to sterility, but recently, its pollen has been successfully used in backcrosses. It was first described as an artificial cross between Syagrus romanzoffiana (Cham.) Glassman and Butia odorata (Barb.Rodr.) Noblick in 1890. It has been considered rare in nature, and its morphology has been little studied. Thus, we aimed to verify if ×B. nabonnandii is sterile by studying its morphology and seed germination from different natural populations. The hybrid was sampled in four municipalities and is new to three of these. In one of the visited cities, 20 specimens were counted. The vegetative morphology showed less variation than the reproductive. However, part of the vegetative characters differed from previous descriptions relying solely on cultivated specimens. Contrary to previous reports, our data indicate that ×Butyagrus nabonnandii is neither rare nor infertile. Seed germination rates of ×B. nabonnandii are low due to seed predation by beetle larvae and seedless fruit production, which is also observed in the genera of the parental species. Furthermore, as in its parents, the morphology of the hybrid is complex, and future anatomical and molecular approaches are important for a better delimitation and understanding of the biology of ×B. nabonnandii.

Resumo ×Butyagrus nabonnandii (Prosch.) Vorster é conhecida como palmeira-mula por ser considerada estéril, apesar de ter sido utilizada com sucesso em retrocruzamentos. O híbrido resulta do cruzamento entre Syagrus romanzoffiana (Cham.) Glassman e Butia odorata (Barb.Rodr.) Noblick, é tido como raro e possui morfologia pouco estudada. Objetivou-se estudar a morfologia de ×B. nabonnandii e verificar sua esterilidade através da germinação de suas sementes a partir de diferentes populações naturais. O híbrido foi registrado em quatro municípios sendo, em três desses, de ocorrência inédita. Em um dos municípios visitados, foram contabilizados 20 espécimes. A morfologia vegetativa apresentou menor variação do que a reprodutiva. Entretanto, parte dos caracteres morfológicos vegetativos diferem do descrito na literatura para espécimes cultivados. Nossos dados indicam que além de não ser raro, o híbrido é fértil. As taxas de germinação das sementes de ×B. nabonnandii são baixas devido à predação das sementes por larvas de besouros, além da produção de frutos sem sementes, o que também ocorre nos gêneros das espécies progenitoras. Além disso, assim como em seus parentais, a morfologia do híbrido é complexa, sendo importantes futuros estudos anatômicos e moleculares para uma melhor delimitação e compreensão da biologia de ×B. nabonnandii.

Abstract Pseudomonas aeruginosa is a non-lactose fermenting Gram-negative bacteria responsible for causing numerous nosocomial infections. The present research aimed to analyze the anti-Pseudomonas aeruginosa potential of 2-Chloro-N-(4-fluoro-3-nitrophenyl)acetamide (A8). The antibacterial potential of A8 was evaluated from the Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC) and Association using the checkerboard method. MIC and MBC values were 512 µg/mL for all P. aeruginosa strains evaluated, demonstrating predominantly bactericidal activity. Furthermore, when A8 was associated with the drug ceftriaxone, pharmacological additivity and indifference were evidenced. In this sense, the synthetic amide was interesting, since it demonstrates the potential to become a possible candidate for an antimicrobial drug.

Resumo Pseudomonas aeruginosa é uma bactéria Gram-negativa não fermentadora de lactose, responsável por causar inúmeras infecções nosocomiais. A presente pesquisa teve como objetivo analisar o potencial anti-Pseudomonas aeruginosa da molécula 2-Cloro-N-(4-fluoro-3-nitrofenil)acetamida (A8). O potencial antibacteriano do A8 foi avaliado a partir da Concentração Inibitória Mínima (CIM), Concentração Bactericida Mínima (CBM) e Associação pelo método de checkboard. Os valores de CIM e CBM foram de 512 µg/mL para todas as cepas de P. aeruginosa avaliadas, demonstrando atividade predominantemente bactericida. Além disso, quando o A8 foi associado ao fármaco ceftriaxona, evidenciou-se aditividade e indiferença farmacológica. Nesse sentido, a amida sintética se mostrou interessante, pois demonstra potencial para se tornar um possível candidato a fármaco antimicrobiano.

Resumen: El objetivo de este artículo de revisión es describir y enmarcar históricamente el uso de la técnica endoscópica en Neumología, las principales indicaciones clínicas para realizar la endoscopia bronquial ultrasónica, las técnicas y equipos utilizados en su ejecución, las complicaciones más frecuentes así como las intervenciones de enfermería. Se utilizó PubMed y SciELO como bases de investigación.

Resumo: Pretende-se com este artigo de revisão descrever e enquadrar historicamente a utilização da técnica endoscópica em Pneumologia, as principais indicações clínicas para a realização de endoscopia brônquica ultrassónica, as técnicas e equipamentos utilizados na sua execução, as complicações mais frequentes bem como as intervenções de enfermagem. Foram utilizadas como bases de pesquisa a PubMed e a SciELO.

Abstract: This review article aims to describe and historically frame the use of endoscopic technique in Pulmonology, the main clinical indications for ultrasonic bronchial endoscopy, the techniques and equipment used in its execution, the most frequent complications as well as nursing interventions. PubMed and SciELO were used as research bases.

Resumen: El consumo de plantas medicinales en nuestro país es una tradición, por ello la importancia de ir incrementando los conocimientos en la morfoanatomía de las especies medicinales, para lograr la correcta identificación y el control de calidad de las mismas. El objetivo de este trabajo fue establecer parámetros morfoanatómicos de diagnóstico, para la correcta identificación y control de calidad del “typycha hũ”, Sida rhombifolia L. (Malvaceae), utilizada como digestiva en la medicina popular paraguaya. Se realizó un estudio observacional, descriptivo y de corte transversal; las muestras fueron recolectadas del Jardín de Aclimatación de la Facultad de Ciencias Químicas de la Universidad Nacional de Asunción, Paraguay. Como resultado se determinaron los siguientes caracteres diagnóstico: hoja anfiestomática, de tipo anisocítico y anomocítico; cuatro tipos de pelos: pelos estrellados unicelulares y pelos glandulares con pie y cabeza globosa unicelular, pelo glandular globoso pluricelular biseriado sésil, y pelo glandular pluricelular de base globosa y alargada en el ápice; mesófilo dorsiventral, colénquima de tipo angular y presencia de cristales de oxalato de calcio en forma de drusas. Se determinaron los caracteres morfoanatómicos de la muestra, para la correcta identificación y control de calidad de esta droga vegetal.

Abstract: The consumption of medicinal plants in our country it is a tradition, therefore the importance of increasing knowledge in the morphoanatomy of medicinal species, to achieve the correct identification and the quality control of the same. The objective of this work was to provide morphoanatomic diagnostic parameters, for the correct identification and quality control of the “typycha hũ”, Sida rhombifolia L. (Malvaceae), used as a digestive in Paraguayan folk medicine. An observational, descriptive and cross section study was carried out; the samples were collected from the Acclimatization Garden of the Faculty of Chemical Sciences of the National University of Asuncion, Paraguay. As result the following diagnostic characters were determined: amphistomatic leaf, anisocytic and anomocytic type; four types of hairs: unicellular stellate hairs and glandular hairs with unicellular globose foot and head, sessile biseriate multicellular globose glandular hair, and multicellular glandular hair with a globose base and elongated at the apex, dorsiventral mesophyll, angular type collenchyma and presence of calcium oxalate crystals in the form of druses. The morphoanatomy characters of the sample were determined, for correct identification and quality control of this plant drug.

Abstract In this work, the electrochemical anodization process was carried out on titanium grade 2, using an electrolytic solution of 3 M and 0.15 M HCl with voltages of 11 V, 12 V and 15 V, as well as time variations in the experimental process and later an annealing process at 750 °C. According to the results obtained, the TiO2 coatings presented different morphologies on their surface, which consisted of nanopores, nanowires and clusters of oxide grains, as well as a combination of anatase and rutile crystalline phases. Band Gap variations were found to be non-significant despite changes in the morphology of the coatings at different anodization conditions, with an average value of 2.91 eV. It was observed that the anodized samples treated by the annealing process at 750 °C, thickness values up to 16 μm were obtained.

Resumen Introducción: Los gramnegativos continúan siendo los causantes de infecciones asociadas a la atención a la salud (IAAS). Material y métodos:: Analizamos la resistencia antimicrobiana de patógenos durante el 2013 vs. 2018 y lo comparamos con lo publicado en 2006 vs. 2012. Resultados: Identificamos nueve patógenos gramnegativos, de un total de 404 aislamientos, con una prevalencia en 2013 (N = 227 [0.22]) vs. 2018 (N = 177 [0.17]) y una incidencia por egresos (6,607 en el 2013 y 7,778 en el 2018) del 3.4 y 2.2% respectivamente. Destacaron tres patógenos: Klebsiella pneumoniae (129 [31.93%]), Pseudomonas aeruginosa (85 [21.03%]) y Escherichia coli (80 [19.80%]). Estos, llamados patógenos ESKAPE-E, prevalecieron como causantes de IAAS. Identificamos un aumento en los patrones de resistencia para muchos patógenos en 2018. Conclusión: La multirresistencia a patógenos ESKAPE-E es un serio problema de salud pública, por carecer de alternativas terapéuticas para enfrentar este reto. Los mapas de resistencia bacteriana ayudan en la prescripción antibiótica.

Abstract Background: Gram-negatives continue to be the cause of infections associated with health care (HCAI). Material and methods: We analyzed the antimicrobial resistance of pathogens during 2013 vs. 2018 and we compare it with what was published in 2006 vs. 2012. Results: We identified 9 gram-negative pathogens, out of a total of 404 isolates, with a prevalence in 2013 (N = 227 [0.22]) vs. 2018 (N = 177 [0.17]) and an incidence due to discharges (6,607 in 2013 and 7,778 in 2018) of 3.4 and 2.2%, respectively.Three pathogens stood out Klebsiella pneumoniae (129 [31.93%]), Pseudomonas aeruginosa (85 [21.03%]) and Escherichia coli (80 [19.80%]). These, called ESKAPE-E pathogens, prevailed as the cause of HCAI. We identified an increase in resistance patterns for many pathogens in 2018. Conclusion: Multi-resistance to ESKAPE-E pathogens is a serious public health problem, due to the lack of therapeutic alternatives to face this challenge. Bacterial resistance maps help in antibiotic prescription.

ABSTRACT Objective: To evaluate the discriminative ability to predict diabetes with anthropometric and biochemical indicators and medical history. Methods: The sampling carried out was census and the sample consisted of 104 workers. A longitudinal study was carried out to evaluate the discriminative ability to predict diabetes with the anthropometric, biochemical, and antecedent indicators, using two models, the analysis of the ROC curves and binary logistic regression. Results: By analyzing the ROC curves, the abdominal circumference obtained greater predictive discriminative power (AUC = 0.747; p <0.001; CI: 0.624-0.870), compared to glycemia (AUC=0.749; p <0.001; CI: 0.645-0.852) and the waist-height index (AUC=0.737; p=0.001; CI: 0.638-0.836). Personal medical history is included in the logistic regression equation P(Y=1)=(1+e0,693+1,897APP)-1to predict the risk of developing diabetes in the future. Conclusions: The abdominal circumference obtained the highest discriminative power, followed by the pathological history.

RESUMEN Objetivo: Evaluar la capacidad discriminativa de predicción de diabetes con indicadores antropométricos, bioquímicos y antecedentes. Métodos: El muestreo realizado fue censal y la muestra estuvo conformada por 104 trabajadores. Se realizó un estudio longitudinal para evaluar la capacidad discriminativa de predicción de diabetes con los indicadores antropométricos, bioquímicos y antecedentes, mediante dos modelos, el análisis de las curvas ROC y regresión logística binaria. Resultados: Mediante el análisis de las curvas ROC, el perímetro abdominal obtuvo mayor poder discriminativo de predicción (AUC=0,747; p<0,001; IC: 0,624-0,870), en comparación a la glicemia (AUC=0,749; p<0,001; IC: 0,645-0,852) y el índice de cintura-talla (AUC=0,737; p=0,001; IC: 0,638-0,836). Los antecedentes patológicos personales se incluyen en la ecuación de regresión logística P(Y=1)=(1+e0,693+1,897APP)-1para predecir el riesgo de tener diabetes en el futuro. Conclusiones: El perímetro abdominal obtuvo mayor poder discriminativo, seguido de los antecedentes patológicos personales.

ABSTRACT Candida auris is an emerging fungus that has gained great relevance as a global public health problem in a short time. The presence of Candida auris in 3 adult patients admitted to a national hospital of high complexity in the last quarter of 2020 in the midst of the COVID-19 pandemic is reported for the first time in Peru. The patients were hospitalized in the ICU, however, this germ was isolated in only 2 patients while they were hospitalized in the ICU. The patients had various comorbidities and long hospitalization times from admission to having their first culture positive for C. auris. All patients acquired a bacterial nosocomial infection at some point during their hospitalization and received broad-spectrum antibiotics. All isolates were resistant to fluconazole. The hospital's infection control team reinforced containment measures and the Ministry of Health of Peru issued an epidemiological alert.

RESUMEN Candida auris es un hongo emergente, con gran relevancia en corto tiempo, como problema de salud pública mundial. Se reporta por primera vez en el Perú la presencia de Candida auris en 3 pacientes adultos internados en un hospital nacional de alta complejidad en el último trimestre del año 2020, durante la pandemia COVID-19. Los pacientes fueron hospitalizados en UCI; sin embargo, solo en 2 pacientes se aisló dicho germen durante su internamiento en UCI. Los pacientes tuvieron varias comorbilidades y tiempos prolongados de hospitalización desde su admisión hasta tener el primer cultivo positivo a C. auris. Todos los pacientes adquirieron una infección nosocomial bacteriana en algún momento de su hospitalización y recibieron antibióticos de amplio espectro. Todas las cepas aisladas fueron resistentes a fluconazol. El equipo de control de infecciones del hospital reforzó las medidas de contención y el Ministerio de Salud del Perú emitió una alerta epidemiológica.

RESUMO Objetivou-se avaliar diferentes modalidades ventilatórias em cães de diferentes idades submetidos à fração inspirada de oxigênio (FiO2) de 40% e 100%. Foram utilizados 36 cães de três grupos etários (GJ: 0-5; GA: 5-10 e GG: 10-15 anos), sem padronização de peso, sexo, raça e procedimento cirúrgico. Foram pré-medicados com acepromazina e morfina (0,02 e 0,5mg/kg), induzidos à anestesia geral com propofol dose-efeito, manutenção do plano anestésico com isoflurano em 1,3 V% e fornecimento de oxigênio conforme a FiO2 estabelecida para o grupo. Os animais foram submetidos a quatro diferentes modalidades ventilatórias: ventilação espontânea (VE), ventilação ciclada a volume (VCV), ventilação ciclada a pressão (VCP) e ventilação ciclada a pressão com PEEP (VCPP), e permaneceram 30 minutos em cada modalidade. Os parâmetros cardiovasculares mantiveram-se estáveis para todas as FiO2, modalidades ventilatórias e idades. Com relação aos parâmetros ventilatórios, na FiO2 100%, foram observados PaCO2 de 45mmHge e 29% de shunt, enquanto a FiO2 40% apresentou PaCO2 de 43 mmHg e 13% de shunt. Em relação às diferentes idades, os animais adultos e geriátricos apresentaram maiores valores de shunt (26% e 22%) e PaCO2 (44mm/Hg e 46mm/Hg). Conclui-se que a fração inspirada de 40% e a modalidade ventilatória ciclada a volume mostraram-se mais eficientes.

ABSTRACT The objective was to evaluate different ventilatory modalities in dogs of different ages submitted to the inspired fraction of oxygen (FiO2) of 40% and 100%. Thirty-six dogs from three age groups (GJ 0-5, GA 5-10 and GG 10-15 years) were used, without standardization of weight, gender, race and surgical procedure. They were premedicated with acepromazine and morphine (0.02 and 0.5mg/kg), induced to general anesthesia with propofol dose/effect, maintenance of the anesthetic plane with isoflurane in 1.3V% and oxygen supply according to FiO2 established for the group. The animals were submitted to 4 different ventilation modalities, spontaneous ventilation (VS), volume-cycled ventilation (VCV), pressure-cycled ventilation (VCP) and pressure-cycled ventilation with PEEP (VCPP) and remained 30 minutes in each modality. The cardiovascular parameters remained stable for all FiO2, ventilatory modalities and ages. Regarding ventilatory parameters, in FiO2 and PaCO2 of 45mmHg and 29% of shunt, in FiO2 100%, PaCO2 of 43mmHg and 13% of shunt were observed. Regarding the different ages, adult and geriatric animals presented higher values of Shunt (26 and 22%) and PaCO2 (44 and 46mmHg). It was concluded that the inspired fraction of 40% and the volume-cycled ventilatory modality were more efficient.