Abstract The Azores archipelago has influenced Portuguese diplomacy for a long time. In 1871, Andrade de Corvo had already defended, in his book Perigos, that bringing Portugal closer to the United States should be one of the priorities of the Portuguese foreign policy, given the geostrategic position of the Azores. This outlook proved to be accurate in the last century, during the two world wars, with the installation of US military bases on these islands. Since then, the Azores have become indispensable for the Power projection of the American military power in the Atlantic, and has been the main reason for the invitation addressed to Portugal to join NATO. If the end of the Cold War, the appreciation of the Pacific and technological development posed serious challenges to the relevance of the Archipelago in the international system, it is necessary that the enlargement of the Portuguese Continental Platform, alone, given the geostrategic importance of the Islands, again it gives them prevalence within the context of Portuguese foreign policy.

Resumo O arquipélago dos Açores influi sobremaneira, desde há muito, na diplomacia portuguesa. Em 1871, já Andrade de Corvo defendera, no seu livro Perigos, que a aproximação de Portugal aos Estados Unidos deveria ser uma das prioridades da política externa portuguesa, dado o posicionamento geoestratégico dos Açores. Esta antevisão mostrou-se certeira no século passado, durante as duas guerras mundiais, com a instalação de bases militares norte-americanas nestas Ilhas. Desde então, os Açores tornaram-se imprescindíveis para a projecção do poder militar norte-americano no Atlântico e foram a principal razão para o convite endereçado a Portugal para aderir à NATO. Se o término da Guerra-Fria, a valorização do Pacífico e o desenvolvimento tecnológico colocaram sérios desafios à relevância do Arquipélago no sistema internacional, é mister que o alargamento da Plataforma Continental Portuguesa, só por si, dado o posicionamento geoestratégico das Ilhas, de novo lhes confira prevalência no âmbito da política externa portuguesa.

Abstract Mosaic partial tetrasomy 10 is a rare chromosomal disorder. It has been associated with several fetal malformations and poor outcome. We report a case with prenatal diagnosis at 22 weeks of gestational age, whose second-trimester ultrasound scan showed several malformations. Fetal karyotype revealed a partial mosaic tetrasomy of chromosome 10 ([47,XY,+idic(10)(q11.2)[11]/46,XY[27]) classified as pathogenic. Medical termination of pregnancy was performed and fetal autopsy confirmed the ultrasound findings. There is only one case of tetrasomy 10p reported in the literature, with similar features and fetal malformations, and by sharing this rare case we hope to help in similar clinical scenarios.

Resumo A tetrassomia parcial em mosaico do cromossoma 10 é um diagnóstico raro e tem sido associada a várias malformações fetais e a maus desfechos. Neste artigo é relatado um caso clínico com diagnóstico pré-natal às 22 semanas de idade gestacional, cuja ecografia do segundo trimestre revelou várias malformações. O cariótipo fetal revelou uma tetrassomia parcial em mosaico do cromossoma 10 ([47,XY,+idic(10)(q11.2)[11]/46,XY[27]) classificada como patogénica. Foi realizada uma interrupção médica da gravidez e a autópsia do feto confirmou os achados ecográficos. Na literatura há apenas um caso de tetrassomia 10p relatado, com malformações fetais semelhantes. Ao divulgar este caso raro pretende-se contribuir para o diagnóstico e aconselhamento pré-natal de situações semelhantes.

ABSTRACT: Bees generally use different botanical sources of resins for the production of propolis. The elucidation of botanical sources of propolis and identification of the effects of seasonality on the chemical profile of propolis are recognized as two important aspects in the development of a high quality product. Thus, our objective was to elucidate the botanical source and identify the effect of the seasons on the chemical profile of propolis produced in southern Brazil. The chemical profile of the samples was analysed by spectrophotometric and chromatographic techniques and the results were coupled to multivariate analysis. Field observation of the foraging behaviour of Apis mellifera L. revealed its preference for the Baccharis dracunculifolia DC. species. p-Coumaric acid, 3, 4-dicaffeoylquinic acid, 3, 5-dicaffeoylquinic acid, drupanin, and artepillin C which were identified in both plant and propolis samples. Moreover, higher artepillin C amounts have been detected in samples collected in the summer and autumn, while the main compounds of p-coumaric acid and quercetin were available in spring and winter sampled propolis, respectively. Baccharis dracunculifolia has been identified as a plant species preferred by A. mellifera in foraging resin for the production of propolis in southern Brazil. The contents of balsam, total phenolic compounds, and flavonoids varied significantly over the seasons, with values above the minimum required by the legislation, thus assuring a quality pattern for this biomass.

Introdução: A trissomia 20 em mosaico é um dos tipos mais comuns de alterações citogenéticas detetadas no diagnóstico pré-natal. O produto destas gestações é normal na maioria dos casos descritos, mas as implicações clínicas do diagnóstico e o prognóstico da doença a longo prazo não são totalmente claros. Caso clínico: Os autores apresentam um caso de trissomia 20 em mosaico, sem diagnóstico pré-natal e com um período de seguimento de 13 anos, pretendendo ilustrar a existência de um fenótipo subtil, o que constitui um desafio no diagnóstico. Discussão/Conclusão: Nenhum fenótipo específico tem sido associado com os achados citogenéticos, mas certas características apesar de subtis parecem ser consistentes.

Introduction: Trisomy 20 mosaicism is one of the most common cytogenetic abnormalities found in prenatal diagnosis. The outcome of these pregnancies is normal in most of the reported cases, but clinical implications of diagnosis and prognosis in a long term basis are not clear. Case report: The authors present a case of trisomy 20 mosaicism, with no prenatal diagnosis, followed-up for a period of 13 years, aiming to demonstrate the existence of a subtle phenotype, which represents a challenge in diagnosis. Discussion/Conclusion: No specific phenotype has been associated with the cytogenetic findings but certain features, although subtle, appear to be consistent.

Resumen Introducción. Conocer sobre hipertensión arterial podría favorecer la adherencia al tratamiento para un mejor control de la presión arterial. Objetivo. Evaluar si existe asociación entre conocimientos sobre hipertensión y adherencia al tratamiento en pacientes hipertensos del Hospital Nacional Edgardo Rebagliati Martins de Lima, Perú. Materiales y métodos. Se realizó un estudio transversal analítico. El muestreo por conveniencia incluyó 340 pacientes hipertensos de consultorios de cardiología en el periodo mayo-agosto de 2015. La variable principal de exposición fue grado de conocimiento sobre hipertensión medida con el cuestionario de conocimientos sobre la hipertensión (CSH) y la variable respuesta fue grado de adherencia al tratamiento medida con el cuestionario Martin-Bayarre-Grau (MBG). Se utilizó regresión de Poisson para calcular razones de prevalencias (RP) con intervalos de confianza del 95% y valor de p<0.05 para establecer significancia estadística. Resultados. Se encontró asociación entre bajo conocimiento de hipertensión y adherencia parcial al tratamiento (RP=1.4; IC95%: 1.2-1.8), tener más de 10 años de hipertensión (RP=0.7; IC95%: 0.6-0.9), no haber recibido información sobre hipertensión (RP=1.4; IC95%: 1.2-1.7) y tiempo de consulta mayor a 15 minutos (RP=0.5; IC95%: 0.3-0.7). Conclusión. Los pacientes con bajo conocimiento de hipertensión tienen más probabilidad de tener adherencia parcial al tratamiento.

Abstract Introduction: Knowing about arterial hypertension could favor adherence to treatment for better control of blood pressure. Objective: To evaluate the association between hypertension awareness and adherence to treatment in hypertensive patients at Hospital Nacional Edgardo Rebagliati Martins in Lima, Perú. Materials and methods: An analytical cross-sectional study was performed, including a convenience sampling of 340 hypertensive patients from cardiology clinics, during the period May-August 2015. The main variable was awareness of hypertension, which was measured using the hypertension awareness questionnaire (CSH, by its acronym in Spanish); the response variable obtained corresponds to the degree of adherence to the treatment, which was measured through the Martin-Bayarre-Grau (MBG) questionnaire. The Poisson regression was used to calculate prevalence ratios (PR) with 95% confidence intervals and a p value of <0.05 to establish statistical significance. Results: There is an association between low awareness ofhypertension and partial adherence to treatment (PR=1.4, 95% CI: 1.2-1.8), a history of more than 10 years of hypertension (PR=0.7, 95% CI 0.6-0.9), not receiving enough information onhypertension (PR=1.4, 95% CI: 1.2-1.7) and consultation time longer than 15 minutes (PR=0.5, 95% CI: 0.3-0.7). Conclusion: Patients with low knowledge on hypertension are more likely to have partial adherence to treatment.

Introdução: A haploinsuficiência do gene SHOX (short stature homeobox gene) é uma das causas genéticas mais frequentes de baixa estatura isolada ou familiar, cuja gravidade clínica pode ser muito variável. Caso Clinico: Os autores descrevem uma adolescente de 14 anos, com membros curtos e baixa estatura. A radiografia do punho demonstrou deformidade de Madelung. O estudo molecular revelou a deleção do gene SHOX (FISH del (X) (Xp22.3Xp22.3) (SHOX). Um exame físico cuidadoso assume extrema importância na avaliação clínica de baixa estatura. A deformidade de Madelung pode surgir apenas na adolescência. O tratamento com Hormona de Crescimento pode aumentar a estatura final. Discusão/conclusões: A prevalência de baixa estatura por mutações do gene SHOX parece ser semelhante ao défice de hormona de crescimento e Sindroma de Turner. O objectivo dos autores foi chamar a atenção sobre esta entidade clínica não muito conhecida, que pode ter implicações terapêuticas com um diagnóstico atempado.

Introduction: SHOX gene (short stature homeobox gene) deficiency is one of the most frequent genetic causes of isolated or familial short stature, with highly variable clinical severity. Case-report: The authors describe a 14 year-old-girl, with short limbs and short stature. The wrist X-ray showed Madelung deformity. The molecular study showed deletion of the SHOX gene (FISH del (X) (Xp22.3Xp22.3) (SHOX). A very careful physical examination, including measurement of body proportions, is of extreme importance in the clinical evaluation of short stature. The Madelung deformity can only appear in the adolescence. Treatment with growth hormone can improve the final height. Discussion/Conclusions: The prevalence of short stature due to SHOX gene mutations among children with short stature appears to be similar to that of Growth Hormone deficiency or Turner syndrome. The authors’ intention is to draw attention to this clinical entity, since a timely diagnosis can have therapeutic implications.