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Background: In our country, transplantation centers differ in the age limit for allogeneic hematopoietic transplantation (ALOHT). In our program, transplants with age- adjusted conditioning are performed in patients until 70 years old. Currently more than 60% of ALOHT reported to the Center for International Bone Marrow Transplantation Research (CIBMTR) are performed in patients older than 40 years. Aim: To report our experience with ALOHT in acute myelogenous leukemia (AML), analyzing patient age at transplantation in different periods and transplant results in different age groups. Material and Methods: A retrospective analysis of the database of adult hematopoietic transplants in AML patients was performed. Demographic data, disease characteristics, transplant data, survival and relapse times, and mortality were collected. Results: In our program, 1030 transplants were performed in adults and 119 ALOHT were performed in AML patients, between 1990 and 2020. The median age of patients in all periods was 41 years, (range 16-69). The median age was 33 and 45 years, in the periods 1990-2000 and 2000-2020 respectively (p < 0.01). Seventy-eight patients received myeloablative conditioning (median age 44 years) and 41 reduced intensity conditioning (median age 53 years). Five-year overall survival was 44.6% (confidence intervals (CI) 41-48). Non relapse mortality of all periods was 19% (CI 17 - 40%) and relapse rate was 17 % (CI 16-22). No difference in five years overall survival among patients younger than 40, 41 to 50 and over 51 years was observed. Conclusions: Overall Survival, non-relapse mortality and relapse rate were similar in younger and older patients in our program and similar to those previously reported in other centers.

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Haploidentical transplantation outcomes are comparable with those obtained with identical human leukocyte antigen allogeneic transplantation in Chilean patients with benign and malignant hemopathies
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Sarmiento, Mauricio

; Ramirez, Pablo

; Jara, Veronica

; Bertin, Pablo

; Galleguillos, Mauricio

; Rodriguez, Isabel

; Lorca, Carla

; Pizarro, Isabel

; Rivera, Elizabeth

; Ocqueteau, Mauricio

Hematology, Transfusion and Cell Therapy

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Mar 2020, Volume 42 Nº 1 Páginas 40 - 45

Resumo: En | Texto: En | PDF: En

Abstract Introduction Patients with benign or malignant blood disorders, who require allogeneic stem cell transplantation and lack an identical human leukocyte antigen HLA identicalHL sibling donor, could be transplanted with hematopoietic stem cells from unrelated adult or umbilical cord donors. However, in our country, both approaches are costly and time-consuming options. Methods Over the last few years, haploidentical modalities have been investigated as an alternative donor source, showing similar results to those obtained with identical HLA donors. We started using T-cell-replete haploidentical with post-transplant cyclophosphamide in 2012 and we presented our experience with patients undergoing haploidentical ransplantation compared to SIB. Results Since January 2012 to date, 91 allogeneic transplants have been performed, of which 49 were haploidentical and 42 were HLA identical. The mean age of the patients was 35 years (range: 17–62). The mean CD34/kg × 106 infused per group was 5.93 and 5.89, respectively. Time to granulocyte and platelet engraftment was 11 and 15 days, respectively, for haploidentical, and 12 and 14 days, respectively, for HLA identical (p = 0.10). The 100-day cumulative incidence of global acute GVHD was 34% for haploidentical and 29% for SIHLA identical (p = 0.9). The 2-year overall global graft-versus-host disease was 43% for haploidentical and 41% for HLA identical (p = 0.8). Overall survival, relapse, and transplant and relapse-related mortality were similar between both groups. Conclusion Our experience showed that haploidentical has similar outcomes to those obtained with HLA idential and can be performed in our country safely.

https://doi.org/10.1016/j.htct.2019.01.010 302 downloads

ASSESSING THE BIOAVAILABILITY AND BIOACCESSIBILITY OF TOTAL ARSENIC AND ARSENIC SPECIES IN ENVIRONMENTAL SAMPLES
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PIZARRO, ISABEL

; ROMAN, DOMINGO

; GOMEZ, MILAGROS

; PALACIOS, M. ANTONIA

Journal of the Chilean Chemical Society

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Set 2017, Volume 62 Nº 3 Páginas 3653 - 3657

Resumo: En | Texto: En | PDF: En

ABSTRACT Studies on the bioavailability of As, of impacted vegetables; and As bioaccesibility in the edible parts of carrots (daucus carota), beets (beta vulgaris) and quinoa (chenopodium) growing in polluted soils thought “in vitro” gastrointestinal process; the As speciation both in the edible parts of vegetables and in their gastrointestinal extracts have been performed. Elemental analysis and As speciation have been performed by ICP-MS and LC-ICP-MS, respectively. The Arsenic recovery after the in vitro gastrointestinal digestion was from 98, 90 and 40% for carrots, beets and quinoa, respectively; with no significant transformation of original As species. These studies provide a clearer understanding of the impact that As and other contaminant elements may present in the population of this high polluted Chilean region.

https://doi.org/10.4067/s0717-97072017000303653 1019 downloads

Metáfora concetual e literariedade: a “Hora” de Fernando Pessoa
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Pizarro, Isabel

; Teixeira, José

Revista Diacrítica

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2016, Volume 30 Nº 1 Páginas 139 - 161

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

A análise que apresentamos insere-se no domínio da Linguística Cognitiva e resulta da aplicação dos instrumentos de análise da metáfora poética, propostos por Lakoff e Turner (1989) no âmbito da Teoria da Metáfora Concetual, postulada por Lakoff e Johnson (1980 e 1999) e por Lakoff e Feldman (2006), à metaforização de “hora”, nos poemas ortónimos de Fernando Pessoa (1888-1935), escritos entre 1910 e 1935. Neste texto, apenas iremos utilizar um pequeno corpus do total, constituído por seis excertos de poemas ortónimos nos quais o item lexical “hora” designa metonimicamente a categoria superordenada Tempo, através da metonímia concetual HORA POR TEMPO. As metáforas de “hora” são complexas, o que significa que resultam da combinação hierarquizada de metáforas convencionais de nível específico e genérico que constituem o background sociocultural que constrange a criatividade do poeta e do qual emerge a metaforização de “hora”, realizada com base nos quatro mecanismos concetuais em que assenta a construção da metáfora poética: extensão, elaboração, questionamento e combinação.

ABSTRACT The analysis hereby presented is inserted in the dominium of Cognitive Linguistics and aims at applying the instruments of poetic metaphor analysis, as proposed by Lakoff and Turner (1989) within the ambit of The Conceptual Metaphor Theory, postulated by Lakoff and Johnson (1980 and 1989) and by Lakoff and Feldman (2006), to the metaphor of “hour”, in the orthonymous poems of Fernando Pessoa (1888-1935), written between 1910 and 1935. In order to achieve such purpose, we started from a corpus constituted by six excerpts of poems in which the lexical item “hour” designates metonymically the superordinate category TIME, trough the conceptual metonymy HOUR FOR TIME. The metaphors of “hour” are complex, which means that they are the result of the hierarchical combination of conventional metaphors of a specific and general level which constitute the social background that restrains the poet's creativity and out of which the process of creating the metaphor of “hour” emerges, based on the four conceptual mechanisms in which the construction of the poetic metaphor lies: extension, elaboration, questioning and combination.

1463 downloads

Trasplante alogénico de precursores hematopoyéticos de sangre de cordón umbilical de donante no emparentado: primera experiencia, en tres casos, con donantes del banco público chileno de células de cordón
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Barriga, Francisco

; Wietstruck, Angélica

; Rojas, Nicolás

; Bertin, Pablo

; Pizarro, Isabel

; Carmona, Amanda

; Guilof, Alejandro

; Rojas, Iván

; Oyarzún, Enrique

Revista médica de Chile

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Ago 2013, Volume 141 Nº 8 Páginas 1064 - 1067

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Public cord blood banks are a source of hematopoietic stem cells for patients with hematological diseases who lack a family donor and need allogeneic transplantation. In June 2007 we started a cord blood bank with units donated in three maternity wards in Santiago, Chile. We report the first three transplants done with cord blood units form this bank. Cord blood units were obtained by intrauterine collection at delivery. They were depleted of plasma and red cells and frozen in liquid nitrogen. Tests for total nucleated cells, CD34 cell content, viral serology, bacterial cultures and HLA A, B and DRB1 were done. Six hundred cord blood units were stored by March 2012. Three patients received allogeneic transplant with cord blood from our bank, two with high risk lymphoblastic leukemia and one with severe congenital anemia. They received conditioning regimens according to their disease and usual supportive care for unrelated donor transplantation until full hematopoietic and immune reconstitution was achieved. The three patients had early engraftment of neutrophils and platelets. The child corrected his anemia and the leukemia patients remain in complete remission. The post-transplant course was complicated with Epstein Barr virus, cytomegalovirus and BK virus infection. Two patients are fully functional 24 and 33 months after transplant, the third is still receiving immunosuppression.

3837 downloads

Identificación y cuantificación del arsénico unido a las proteínas de tejidos cardiovasculares de pacientes sometidos a cirugía de revascularización coronaria
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Pizarro, Isabel

; Román, Domingo

; Solar, Carlos

; Cámara, Carmen

; Palacios, María Antonia

; Gómez, María Milagros

Revista chilena de cardiología

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2013, Volume 32 Nº 2 Páginas 123 - 129

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Background: The effects of arsenic (As) toxi-city - cardiovascular disease, pigmentation, coronary artery occlusion- come from ingestion of contaminated drinking water and environmental exposure. Protein linkage or As(III) and As methylation may be a first step in detoxification. The aim of this study is to evaluate protein linkage of As in the right atrium (RA) and saphenous vein (SV) of As exposed subjects from Antofagasta, Chile Method: As-protein linkage was studied in the cytosol of AD and SV obtained from 6 patients operated on for coronary artery disease. Molecular exclusion columns of 3 different mass ranges were used to obtain the cytosol fraction. As species were detected by induction coupled mass spectrometry and visible ultraviolet spectrometry (links of As and protein thyolates). Results: As was widely distributed in AD and SV in all subjects. As collected in the 3 different columns used were 10%, 25% and 50%. Only As(III) and As(V) were obtained through the method used (IC-HPLC-ICP-MS); a normal distribution was evident for both As species. The relation As(III)/As(V) was similar in AD and SV. Conclusion: A linkage of As and proteins through neighbor sulphidryl groups is present in cardiovascular tissues of exposed subjects. It is likely that As is linked to >80 kDA protein fractions and to quaternary subu-nits or the native protein.

Introducción: Los efectos de la intoxicación con Arsénico (As) como enfermedades cardiovasculares (CV), pigmentaciones y oclusiones arteriales coronarias están asociados con la ingestión de As inorgánico a través del agua de bebida y a exposiciones ambientales. La unión del As (III) a proteínas y la metilación del As podría ser una primera etapa en el mecanismo de detoxificación. Objetivo: Evaluar la unión de As a proteínas en aurícula derecha y vena safena (VS) en sujetos expuestos de la Región de Antofagasta. Métodos: Se estudió la asociación As-proteína en el citosol de AD y VS de 6 pacientes con enfermedad coronaria grave de la Región de Antofagasta. Para el fraccionamiento del citosol se utilizaron columnas de exclusión molecular de tres diferentes rangos de masas. El perfil del As se detectó por Espectrometría de Masas Inductivamente Acoplado (ICP-MS) y por Espectrosco-pía Ultra Violeta - Visible de las fracciones moleculares (enlaces As- tiolatos de proteínas). Resultados: En todos los casos el As estuvo ampliamente distribuido en todo el intervalo de fracciones para AUD y VS. Los porcentajes de As colectado en las fracciones de las diferentes columnas usadas fueron 10, 25 y 50%. En la especiación de As en el citosol, por Cromatografía Líquida de Alta Resolución acoplada a la Espectrometría de Masas (IC-HPLC-ICP-MS), solamente se encontró As(III) y As(V) con una distribución Gaussiana para ambas especies, siendo la relación As(III)/As(V) constante para AUD y VS. Conclusión: En los tejidos CV existe asociación As - proteína lo cual podría implicar que el As está unido a biocompuestos de diferente peso molecular a través de grupos sulfhidrilos vecinales. Es probable que el As en AUD y VS se una a fracciones proteicas de masa molecular superior a 80 kDA y a subunidades de la estructura cuaternaria de la proteína nativa.

2661 downloads

NIVELES DE ELEMENTOS TRAZA EN TEJIDOS CARDIOVASCULARES DE PACIENTES SOMETIDOS A CIRUGÍA CARDÍACA EN LA REGIÓN DE ANTOFAGASTA, CHILE
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Román, Domingo

; Solar, Carlos

; Pizarro, Isabel

Revista chilena de cardiología

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2013, Volume 32 Nº 3 Páginas 214 - 220

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

The Antofagasta population is exposed to environmental contamination with heavy metals (HM). Trace elements (TE) might interact with As either as agonists or antagonists. The total concentracions of V, Cr, Mn, Co, Ni, Cu, Se and B in the right atrium (RA), left internal mammary artery (LIMA), saphenous vein (SV) and adipose tissue (AT) from patients undergoing cardiac surgery are reported. Methods: LIMA, SV, RA and AT from 50 patients with myocardial infarction submitted to revascularization surgery in Antofagasta (exposed group, E) or Santiago (non exposed group NE, 20 patients) were analyzed. Optical and atomic techniques were used for analysis of HM and TE. Results: Significant inter elemental correlations were observed for B in group E, (p<0.05), which are not present in group NE. The RA concentrarion of B in group A ranged from 24.72 to 932.03 ug/g, substancially higher than concentracion of the other elements under study. Corresponding concentra-rions of B in the NE group were 25.21 to 56. 87 ug/g. Conclusion: B was the most enriched element in the exposed group, followed by As and Mn. Cu content was significantly lower in RA and LIMA from patients in the non exposed group.

Introducción: La población de la Región de Antofagasta se encuentra expuesta a contaminación ambiental por metales pesados (MP). Los elementos traza (ET) podrían actuar con As como agonistas o antagonistas. El presente estudio detalla la determinación de las concentraciones totales (CT) de V, Cr, Mn, Co, Ni, Cu, As, Se y Boro en aurícula derecha (AD), arteria mamaria izquierda (AMI), vena safena (VS) y tejido adiposo (TA) de personas que padecen patologías cardiovasculares (CV) y han requerido cirugía cardíaca. Métodos: Se analizaron AMI, VS, AUD, y TA en un grupo de 50 pacientes con cardiopatía coronaria de la Región de Antofagasta que han sido sometidos a cirugía cardíaca (grupo expuesto, E), y en un grupo de 20 pacientes control sometidos a cirugía cardíaca en el mismo período en Santiago (grupo no expuesto, NE). Las determinaciones de ET y MP se realizaron mediante Técnicas Ópticas y Atómicas. Resultados: En el grupo de pacientes E residentes en la Región de Antofagasta Boro presenta correlaciones interelementales significativas (p=0,05), que no se presentan o son escasas en el grupo NE. El rango de CT de B en AD fue de 24,721 - 932,032 μg/g, niveles muy superiores a los encontrados en el resto de los elementos en estudio. El rango de CT de B encontrada para AD fue de 25,205 - 56,873 μg/g. Conclusión: Individualmente, el elemento más enriquecido en todos los tipos de tejidos del grupo E de la Región de Antofagasta es B, le siguen As y Mn. Cu está empobrecido en el grupo NE, en particular en AD y AMI.

1717 downloads

Presencia de altos niveles de arsénico en tejidos cardiovasculares de pacientes de áreas contaminadas en Chile
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Solar, Carlos

; Pizarro, Isabel

; Román, Domingo

Revista chilena de cardiología

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2012, Volume 31 Nº 1 Páginas 41 - 47

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Introduction: Chronic contamination from arsenic observed in Antofagasta (northern Chile) has been related to increased prevalence of different health problems, foremost among them cardiovascular disease. The present work describes concentrations of arsenic and derived species in cardiovascular tissues obtained at the time of cardiac surgery. The relation of arsenic concentrations and histological damage is described Method: Tissues obtained during performance of coronary artery surgery including saphenous vein (SV), mammary artery (MA), right atrium (RA) and adipose tissue (AT)were obtained from 250 subjects living in Antofagasta (exposed group) and 25 patients from central Chile (non exposed group). Total As levels were determined through atomic absorption spectrometry, and species found in different tissues were identified by ionic chromatography associated to mass spectrometry. Histological samples were stained with H-E, Masson trichromic and Giesson orsein. Results: Arsenic concentrations in the RA were 6,06 ± 1,90 μg/g and 2,26 ± 1,30 μg/g in the exposed and no exposed groups, respectively (p<0.05). Inorganic species of AS were found in the RA whereas methylated species were found in SV and MA. In exposed subject's SV, different grades of concentric intimal fibrosis were observed. Conclusion: The presence of inorganic species, the high As concentration and cardiovascular tissue damage represent the serious contamination affecting the Antofagasta region.

Introducción y objetivos: En la Región de Antofagasta - Chile la contaminación crónica por arsénico es causa de numerosas patologías donde se destacan las enfermedades cardiovasculares. El presente estudio detalla la concentración de arsénico total y sus principales especies encontradas en tejidos cardiovasculares de pacientes que han requerido cirugía cardíaca. Se relacionan los niveles de As con hallazgos histológicos. Métodos: Se analizaron muestras de tejidos obtenidos en el momento de la cirugía coronaria. Se recolectaron muestras de vena safena (VS), aurícula derecha (AD), arteria mamaria interna (AMI) y tejido adiposo (TA) de 250 pacientes autóctonos, avecindados de la Región de Antofagasta, (Grupo Expuesto) y de 25 pacientes de la Región Metropolitana, (Grupo no Expuesto). El arsénico total se determinó mediante espectrofotometría de absorción atómica y las especies presentes en dichos tejidos por cromatografía iónica acoplada a espectrometría de masas. Se realizó un estudio histológico en cortes de bloques de parafina teñidos con Hematoxilina - Eosina, Tricrómico de Masson y Orceína Giesson. Resultados: La concentración total de arsénico encontrada en la AD fue de 6,06 ± 1,90 μg/g en el Grupo Expuesto, y de 2,26 ± 1,30 μg/g en el Grupo no Expuesto (p < 0,05). En la AD se encontraron las especies inorgánicas, mientras que en la VS y AMI se encontraron especies metiladas de arsénico. En el grupo expuesto, la VS presentó fibrosis intimal concéntrica en diferentes grados. Conclusiones: La presencia de especies inorgánicas, la alta concentración total de arsénico y el daño encontrado en los tejidos cardiovasculares encontrados en el grupo expuesto, reflejan el gran impacto de la contaminación de arsénico sobre tejidos cardiovasculares de pacientes de la Región de Antofagasta.

6094 downloads Citado 3 vezes em SciELO

TOTAL AND MAIN As SPECIES PRESENT IN CARDIOVASCULAR TISSUES OF PEOPLE LIVINGIN As CONTAMINATED AREAS
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PIZARRO, ISABEL

; ROMÁN-SILVA, DOMINGO

; SOLAR, CARLOS

; GÓMEZ, MARÍA MILAGROS

; CÁMARA, CARMEN

; PALACIOS, MARÍA ANTONIA

Journal of the Chilean Chemical Society

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2012, Volume 57 Nº 2 Páginas 1181 - 1187

Resumo: En | Texto: En | PDF: En

The concentration levels of As in the Chilean II Region of Antofagasta produces non cancer health outcomes such as cardiovascular diseases and in last term heart attack. On this study, the determination of total As content and main inorganic and organoarsenic species found in three heart tissues (auricle, mammary artery and fat) and the saphene vein of people living in the Chilean II Region, suffering coronary thrombosis has been carried out. Comparison with similar tissues of patients from other non-contaminated areas has been undertaken. The extraction of As species occurred in methanol: water (1:1) and As species determination have been used the tandem HPLC-ICP-MS using the Hamilton PRP X100 anion column. For total As determination has been performed by HG-AAS and ICP-MS. The auricle and in less extend the saphene support the higher As concentration (mean values of 7.7 and 2.5 μg g-1, respectively), being As(III) the predominant species. Methylarsonate (MA) and dimethylarsinate (DMA) is not a favoured mechanism. The presence of high total As and high As(III) species content in the auricle and saphene of more contaminated people, the damage found in the saphene tissue and the global characteristics of the people under study in which the As stigmas are present in all of them, suggests that As could be involved in the cardiovascular diseases.

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