Abstract The phenolic compound content, the antioxidant and α-amylase inhibition potentials of different extracts of the Plectranthus amboinicus, P. barbatus and P. ornatus were evaluated. We also evaluated the influence of plant growth and harvest time on the chemical composition of the essential oil (EO) of P. amboinicus, its antioxidant and anti-Candida activities and the α-amylase and lipoxygenase inhibitions. The turbo-extract of P. barbatus showed the greatest phenolic compound content and antioxidant activity. No α-amylase inhibition activity was observed in the analyzed extracts, but the turbo-extraction and refluxing extracts possessed high antioxidant activities. Protected cultivation and morning harvest conditions gave the best antioxidant activities, which was associated to the highest carvacrol content. P. amboinicus EO antioxidant activity could contribute to the reduction of oxidative stress in diabetes. Causal Candida strains of diabetic foot ulcers showed sensitivity to P. amboinicus EO. C. albicans and C. dubliniensis were the most sensitive of the selected Candida strains. Turbo-extracts or refluxing of the three species extracts and the EO of P. amboinicus should be considered as a potential candidate for the management the complications of type 2 diabetes.

Abstract Poly(vinyl chloride) (PVC) resins constitute the third most important plastic materials available commercially, in terms of worldwide volume production, and can be manufactured through several polymerization mechanisms, including free radical, ionic and redox polymerization processes. Approximately 80% of the worldwide commercial PVC production is performed through suspension polymerization processes in batch mode, due to intrinsic problems of continuous suspension polymerization processes, such as polymer incrustation in reaction vessels, transport equipment and pipes. For this reason, the present review provides an extensive bibliometric survey, including papers and patents, on attempts to develop continuous polymerization process technologies for PVC manufacture. Particularly, the present survey characterizes the degree of maturity and the main bottlenecks of continuous PVC processes that have been frequently overlooked in the technical literature.

Abstract Introduction: Currently, people living with HIV/ AIDS (PLWHA) attain a life expectancy similar to a non-HIV population. However, these patients experience a status of chronic inflammation, which is a known cause of arteriopathy. Yet, literature is scarce regarding the potential venous inflammatory effect, especially after varicose vein surgery. The aim of this study was to perform a descriptive analysis alongside evaluating short and long-term outcomes after varicose vein surgery in PLWHA while comparing with a control group. Methods: A retrospective nested case-control study was performed resorting to codification. All PLWHA patients which had any hospital interaction with the Vascular Surgery Department (either outpatient clinic, emergency or surgery) due to venous disease between April 2006 and December 2019 were identified. PLWHA found to have undergone varicose vein surgery within the study inclusion period were included. The immediately consecutive varicose vein surgery in a patient with no-HIV infection was included in the control group in a 1:1 ratio. Comorbidities were collected at the time of index event. Results: The cohort included 118 patients (59 PLWHA and 59 control) and had a mean follow-up of 86 [Interquartile range (IQR) 25-75%, 43-111] months. At baseline, PLWHA were younger (45.2 ± 10.71 vs 49.9 ± 10.69 years, p=0.017) and had a male predominance (54% vs 27%, p=0.003). Furthermore, there were a higher prevalence of smokers (54% vs 17%, p<0.001) and history of drug abuse (34% vs 2%, p<0.001) in the study group. Although not statistically significant, PLWHA presented higher pre-operative CEAP classifications. Regarding post-operative outcomes, no differences were found for complications, reinterventions or overall-mortality. Conclusion: To the authors knowledge, this is the first study addressing varicose vein treatment in PLWHA. In summary, PLWHA undergoing varicose vein surgery seem to be younger and have higher CEAP classifications. Nonetheless, short and long-term outcomes seem to be good and similar to a control population. Further studies with larger populations and disease specific outcomes are necessary to confirm such findings.

Abstract Introduction: Abdominal compartment syndrome (ACS), defined as intra-abdominal pressure (IAP) greater than 20 mm Hg that is associated with new organ dysfunction/failure, represents an uncommon but hazardous complication after endovascular aneurysm repair for ruptured abdominal aortic aneurysms (r-EVAR). The aim of this review is to overview incidence, mortality, and potential benefit of expedite treatment of ACS. Methods: PubMed databases were searched in order to find publications reporting incidence associated mortality of ACS after r-EVAR. Articles published before 2002 and non-human data was not included. Results: In studies including a large population (n>100) ACS incidence ranged between 6.9 to 20%, with significant disparity between studied cohorts. Significant heterogeneity was also found regarding in-hospital mortality, ranging between 30 to 83%. One study reported that the need for decompressive laparotomy carried a significantly greater risk of in-hospital mortality (odds ratio 5.91; 95% confidence interval, 3.62-9.62; P<.001). Medical treatment options for reducing IAP represent the first step whenever intra-abdominal pressure > 12mmHg. When the latter is ineffective, decompressive laparotomy is mandatory to avoid multi-organ failure. No studies comparing effectiveness of decompressive laparotomy exist in the literature as this represents a rescuing measure. Conclusion: Abdominal compartment syndrome represents a potentially lethal complication after rEVAR. Close abdominal pressure monitoring along with expedite decompressive laparotomy is mandatory to improve survival of such patients.

RESUMO: Pogostemon cablin (Blanco) Benth. é uma espécie aromática popularmente conhecida como patchouli. O óleo essencial rico em patchoulol extraído de folhas é utilizado pelas indústrias farmacêuticas. O objetivo foi investigar os efeitos das malhas e intensidades de sombreamento no crescimento, anatomia, composição química e teor de óleo essencial de P. cablin. O experimento foi conduzido com dois tipos de malhas (preta e Aluminet), três intensidades de luz (30, 50 e 70% de sombreamento) e pleno sol. As diferentes intensidades de luz influenciaram o crescimento, o rendimento e a composição química do óleo essencial. Plantas de patchouli cultivadas em ambiente sombreado apresentaram maiores valores para os pesos secos de folha, caule, raiz e total em relação ao pleno sol. Com 50% de sombreamento, Aluminet proporcionou ganho de peso seco de caule e total. Aluminet e malha preta a 50 e 70% de sombreamento aumentam o rendimento do óleo essencial. Os teores de patchoulol e pogostol foram maiores a pleno sol, malha preta e Aluminet com 50% de sombreamento. O ambiente para o cultivo do patchouli pode ser melhorado com o uso de malhas de sombreamento, especialmente com Aluminet em 50% de sombreamento.

ABSTRACT: Pogostemon cablin (Blanco) Benth. is an aromatic species popularly known as patchouli. The essential oil rich in patchoulol extracted from leaves is used by the pharmaceutical industries. The objective was to investigate the effects of shade nets and shading intensities on P. cablin growth, anatomy, chemical composition and essential oil content. The experiment was conducted with two types of shade nets (black and Aluminet), three light intensities (30, 50, and 70% shading) and full sun. The different light intensities influenced the growth and the essential oil yield, and chemical composition. Patchouli plants grown in an environment with shading showed higher values for the leaf, stem, root ant total dry weights compared to full sun. At 50% of shading, Aluminet provided gain in stem and total dry weights. Aluminet and black net at 50 and 70% of shading enhance essential oil yield. Patchoulol and pogostol contents were higher under full sun, and, black net and Aluminet at 50% shading. The environment for patchouli cultivation can be improved by use shade nets, especially with Aluminet at 50% of shading.

Abstract Previous studies have investigated the preparation of heterogeneous biocatalysts based on the immobilization of lipases on distinct types of supports. However, few works have investigated the influence of the textural properties of these supports on the immobilization parameters. Thus, the present article reports the preparation of copolymers based on divinylbenzene by aqueous suspension polymerizations, using different amounts of porogenic agents to prepare particles with distinct textural properties. The particles were used for immobilization of lipase from Candida antarctica fraction B and the performance of the biocatalysts was evaluated in hydrolysis reactions, using p-nitrophenyl laurate as substrate. The use of Sty/DVB particles resulted in higher immobilization yields (89.5% and 99.2%) and higher hydrolytic activities, when compared to the Sty/VBC/DVB particles. Particularly, the increase of the pore diameters of the particles resulted in higher immobilization yields. Also, the hydrolytic activities depended simultaneously on the average pore diameter, porosity, and specific area (the most influential variable) of the supports. Thus, it was observed that the distinct morphological features of the polymer support can exert significant and conflicting effects on the final biocatalyst performance, since the specific surface area is normally expected to decrease with the increase of the average pore size.

Abstract The present work reports the implementation of the Hazard Analysis Critical Control Point (HACCP) methodology to analyze the water purification system of a pharmaceutical site, in order to assure the system quality and prevent failures. As a matter of fact, the use of HACCP for development and implementation of Quality Risk Management (QRM) is not usual in pharmaceutical plants and it is applied here to improve the performance of the water purification system of a polymerization pilot plant used to manufacture pharmaceutical grade polymer microparticles. Critical Control Points (CCP) were determined with the aid of a decision tree and questions were made to characterize whether identified hazards constitute actual CCPs and should be monitored. When deviations were detected, corrective actions were performed and action plans were used for following-up and implementation of corrective actions. Finally, microbiological and physicochemical parameters were analyzed and the obtained results were regarded as appropriate. Therefore, it is shown that HACCP constitutes an effective tool for identification of hazards, establishment of corrective actions and monitoring of the critical control points that impact the process and the quality of the final pharmaceutical product most significantly.

Resumo O objetivo deste trabalho foi avaliar a indução de organogênese indireta por concentrações de ácido diclorofenoxiacético (2,4-D) e tidiazurom (TDZ) em explantes de pitaia (Hylocereus undatus), por meio de microscopia eletrônica de varredura e da técnica de citometria de fluxo. Os tratamentos consistiram das concentrações de 0, 2,0 e 4,0 mg L-1 de 2,4-D e TDZ e das combinações desses reguladores. Avaliaram-se as percentagens de cobertura de calos aos 45 e 60 dias. Os explantes submetidos aos tratamentos foram analizados por citometria de fluxo e microscopia eletrônica de varredura. Todos os tratamentos induziram endorreduplicação, e não houve variação somaclonal. Na combinação de 2,0 mg L-1 TDZ e 4,0 mg L-1 2,4-D, calos foram formados em 95% dos explantes, mas foram menores do que os produzidos com 2,4-D separadamente. A concentração de 2,0 mg L-1 de TDZ induz organogênese indireta em explantes de pitaia, comprovada pela presença de vasos condutores por meio da microscopia eletrônica de varredura.

Abstract The objective of this work was to evaluate the induction of indirect organogenesis by concentrations of dichlorophenoxyacetic acid (2,4-D) and thidiazuron (TDZ) in pitaya (Hylocereus undatus) explants, using scanning electron microscopy and the flow cytometry technique. The treatments consisted of the concentrations of 0, 2.0, and 4.0 mg L-1 2,4-D and TDZ and of the combinations of these regulators. Percentages of callus coverage at 45 and 60 days were evaluated. The explants subjected to the treatments were analized by flow cytometry and scanning electron microscopy. All treatments induced endoreduplication, and there was no somaclonal variation. Under the combination of 2.0 mg L-1 TDZ and 4.0 mg L-1 2,4-D, calluses were formed in 95% of the explants, but were smaller than those produced with 2,4-D separately. The concentration of 2.0 mg L-1 TDZ induces the indirect organogenesis in pitaya explants, confirmed by the presence of conducting vessels through scanning electron microscopy.

Resumo Introdução: As complicações cardiovasculares são das mais frequentes após cirurgias não cardíacas. Entre elas, a lesão miocárdica após cirurgias não cardíaca (MINS) tem ganho relevância como fator de risco para morbi-mortalidade cardiovascular no período pós-operatório. Apresenta uma incidência estimada de 8% após cirurgia não cardíaca e está associada a um risco 5 vezes maior de ocorrência de eventos cardiovasculares major (MACE). O objetivo deste trabalho é realizar uma revisão da literatura disponível da MINS no contexto da Cirurgia Vascular Métodos: Foi realizada uma pesquisa na Medline com o objetivo de identificar artigos relacionados com a patofisiologia da MINS e o seu significado no contexto específico de Cirurgia Vascular. Artigos considerados relevantes para o tema em questão foram também analisados para esta revisão não-sistemática e incluídos por cruzamento de referências. Resultados: A MINS na Cirurgia Vascular tem uma incidência estimada de pelo menos 15%, sendo superior à média das outras especialidades. Tal como nas restantes áreas, tem sido validada como fator de risco para morbi-mortalidade cardiovascular. No entanto, o seu rastreio por rotina apenas está recomendado em doentes com alto risco cardíaco. Apesar de a medidas de prevenção não serem consensuais, o dabigatrano e a estatinas demonstraram potencial na reversão do prognóstico a longo prazo desta população. Conclusão: Com base na evidência disponível, o diagnóstico de MINS em doentes submetidos a uma cirurgia vascular está associado a um aumento do risco dos efeitos adversos e mortalidade. No entanto, esta permanece uma área ainda por explorar na Cirurgia Vascular.

Abstract Introduction: After noncardiac surgery, cardiac complications are common. Recently there is one that has gained notoriety as risk factor for cardiovascular morbidity and mortality, myocardial injury after noncardiac surgery (MINS). It has an estimated incidence of 8% and is associated with an increased risk of major adverse cardiovascular events (MACE). Thus, the aim of this paper is to review the available literature regarding MINS in Vascular Surgery. Methods: A Medline search was performed in order to identify articles focused on MINS and its pathophysiology and effect on outcomes in Vascular Surgery. Additional articles of scientific interest for the purpose of this non-systematic review were included by cross-referencing. Results: The incidence of MINS in Vascular Surgery is of at least 15%, higher than in other surgical specialties. As in other areas, MINS has been identified as a risk factor for cardiovascular morbidity and mortality in patients submitted to a vascular surgery. Meanwhile, troponin measurement in the post-operative period is only recommended in high risk patients. Despite the lack of consensus regarding protective factors, dabigatran and statins have showed potential as treatment after the diagnosis of MINS. Conclusion: The available evidence identifies MINS as a factor that carries significant worse outcomes in patients that underwent a vascular surgery, although it remains a largely unexplored area.

Resumo: A partir da constatação trazida pela pesquisa acadêmica sobre a importância da implementação de aspectos de natureza da ciência (NdC) em currículos de ciências, neste trabalho analisamos se há presença de elementos de NdC nos documentos oficiais que regem a educação básica. Foram analisados os Parâmetros Curriculares Nacionais do Ensino Médio, as Novas Diretrizes Curriculares Nacionais da Educação Básica e a Base Nacional Comum Curricular. Isso foi feito a partir da análise de conteúdo e da construção de parâmetros de localidade e inclusão baseados na noção de ciência integral. Apesar de ser uma temática importante em eventos de pesquisa na área e com um número expressivo de publicações, os documentos oficiais não se referem explicitamente à natureza da ciência, fazendo menções superficiais a discussões sobre as ciências e suas características.

Abstract: Based on the results brought about by academic research on the importance of implementing aspects of nature of science (NOS) in science curricula, in this paper, we analyze whether NOS elements are present in official documents that govern middle education. The National Curriculum Parameters for High School, the New National Curriculum Guidelines for Basic Education, and the Common National Curriculum Base were analyzed. The analysis was carried out using content analysis and the construction of location and inclusion parameters based on whole science. Despite being a relevant theme in scientific research events in the area with many publications, official documents do not explicitly refer to nature of science, making only superficial mentions to discussions about sciences and their characteristics.

RESUMO Racional: A criação de um banco de dados clínicos informatizado com a capacidade de coletar informações dos pacientes de forma prospectiva e com possibilidade de resgate e cruzamento viabiliza estudos científicos de maior qualidade e credibilidade em menor tempo. Objetivos: Validar em único protocolo mestre os dados clínicos referentes à Cirurgia do Aparelho Digestivo de forma multiprofissional incorporando-o na plataforma SINPE©, e verificar a incidência das doenças digestivas com base nas coletas prospectivamente realizadas. Método: Organizar no software em estrutura padronizada todos os itens pré-existentes no banco de dados do SINPE©, informatizar a base teórica através do módulo MIGRASINPE© criando-se um único protocolo mestre multiprofissional para uso como um todo. Resultados: Foram criados e/ou adaptados os protocolos específicos existentes que correspondem às doenças digestivas mais prevalentes unificando-os. Criou-se a possibilidade de uso multiprofissional integrando todos os dados coletados da medicina, enfermagem, fisioterapia, nutrição e gestão em saúde de maneira prospectiva. O total foi de 4.281 coletas assim distribuídas: vias biliares extra-hepáticas, n=1.786; esôfago, n=1015; anorretais, n=736; cólon, n=550; intestino delgado, n=86; pâncreas, n=71; estômago, n=23; fígado, n=14. Conclusões: A validação da unificação e estruturação em único protocolo mestre dos dados clínicos referentes à Cirurgia do Aparelho Digestivo de forma multiprofissional e prospectiva foi possível e o estudo epidemiológico realizado permitiu identificar as doenças mais prevalentes nesse aparelho.

Abstract Background: The creation of a computerized clinical database with the ability to collect prospective information from patients and with the possibility of rescue and crossing data enables scientific studies of higher quality and credibility in less time. Aim: To validate, in a single master protocol, the clinical data referring to Surgery of Digestive System in a multidisciplinary way, incorporating in the SINPE© platform, and to verify the incidence of digestive diseases based on the prospectively performed collections. Method: Organize in one software, in a standardized structure, all the pre-existing items in the SINPE© database; the theoretical basis was computerized through the MIGRASINPE© module creating a single multiprofessional master protocol for use as a whole. Results: The existing specific protocols were created and/or adapted - they correspond to the most prevalent digestive diseases - unifying them. The possibility of multiprofessional use was created by integrating all data collected from medicine, nursing, physiotherapy, nutrition and health management in a prospective way. The total was 4,281 collections, distributed as follows: extrahepatic biliary tract, n=1,786; esophagus, n=1015; anorectal, n=736; colon, n=550; small intestine, n=86; pancreas, n=71; stomach, n=23; liver, n=14. Conclusions: The validation of the unification and structuring in a single master protocol of the clinical data referring to the Surgery of the Digestive System in a multiprofessional and prospective way was possible and the epidemiological study carried out allowed to identify the most prevalent digestive diseases.

ABSTRACT Many infants are nurtured with milk supplied by human banks, whose bacteriological and physical-chemical profiles are a major issue. We investigated the bacteriological and physical-chemical characteristics, as well as genotypic and phenotypic and profiles of Staphylococcus species isolated from 240 samples of breast milk from a bank in a teaching hospital. Dornic acidity of milk revealed that 95.4% (229/240) had acceptable limits (< 8.0 oD). Caloric intake showed a wide variation in cream content (4%), fat (4%) and energy values (559.81 Kcal/L). Staphylococcus (105/186 or 56.5%) and Enterobacter (25/186 or 13.4%) were the most prevalent genera, although other microorganisms were identified, including Klebsiella pneumoniae and Pseudomonas aeruginosa. Amoxicillin/clavulanic acid (125/157 or 79.6%), vancomycin (115/157 or 73.2%), and cephalexin (112/157 or 71.3%) were the most effective antimicrobials. High resistance rates of isolates were found to penicillin G (141/157 or 89.8%), ampicillin (135/157 or 86%), and oxacillin (118/157 or 75.2%). Multidrug resistance to ≥ 3 antimicrobials occurred in 66.2% (123/186) of the isolates. Residues of microbial multiplication inhibitory substances were found in 85% (204/240) of samples. Among the coagulase-positive-CPS and negative-CoNS staphylococci, the mecA gene was detected in 53.3% (8/15) and 75% (30/40), respectively. Genes sea, seb and sec were detected in 20% (3/15) of CPS, while tsst-1 was detected in 13.34% (2/15). In addition, 13.3% (2/15) of S. aureus were toxin-producers. Genes sea, seb and sec were detected in 90% (36/40), 5% (2/40) and 15% (6/40) CoNS, respectively. Enterotoxin production was identified in 5% (2/40) of CoNS. The identification of multidrug-resistant bacteria, staphylococci species toxin-producers harboring methicillin-resistance genes, and residues of microbial multiplication inhibitory substances reinforce the need for a continuous vigilance of milk quality offered to infant consumption by human banks.

RESUMO: O estudo teve como objetivo avaliar a influência da sazonalidade na composição química do óleo essencial (OE) de Mentha x piperita L. e Mentha viridis L. cultivadas no sudeste do Brasil. As folhas foram coletadas de novembro de 2011 até agosto de 2013, em meados das seguintes estações: primavera (novembro), verão (fevereiro), outono (maio) e inverno (agosto). A extração do OE foi realizada por hidrodestilação em aparelho de Clevenger por uma hora. A composição química do EO foi analisada por GC-FID and GC-MS. O teor de OE e sua composição química foram influenciados pela sazonalidade em ambas as espécies. O maior teor de OE foi obtido para M. x piperita na primavera (4,26%) e para M. viridis na primavera (3,30%) e verão (3,70%). Mentha x piperita aumentou o conteúdo de mentol (16,31 a 41,26%), neomentol (3,02 a 6,39%) e mentona (5,56 a 41,58%) durante a primavera e o verão, respectivamente. Já o conteúdo de OE de M. viridis não apresentou padrão de resposta de qualidade em relação à sazonalidade. Portanto, a colheita para M. x piperita é recomendada durante a primavera, e para M. viridis é recomendada durante a primavera e verão.

ABSTRACT: This study evaluated the influence of seasonality in essential oil (EO) chemical composition of Mentha x piperita L. and Mentha viridis L. grown in southeast of Brazil. Leaves were collected from November 2011 until August 2013, in the middle of the following seasons: Spring (November), Summer (February), Autumn (May) and Winter (August). EO extraction was carried out by hydrodistillation in Clevenger apparatus for 1 hour. Chemical composition of EO was analyzed by GC-FID and GC-MS. The EO content and its chemical composition were influenced by seasonality in both species. The highest EO content was obtained for M. x piperita during spring (4.26%) and for M. viridis during spring (3.30%) and summer (3.70%). Mentha x piperita increased menthol (16.31 to 41.26%), neomenthol (3.02 to 6.39%) and menthone (5.56 to 41.58%) contents during spring and summer, respectively. Whereas, M. viridis EO content did not show a quality response pattern in relation to seasonality. Therefore, harvest time for M. x piperita is recommended during spring, and for M. viridis is recommended during spring and summer.

Resumo O objetivo do presente artigo é estimar impactos da queda da arrecadação tributária para o financiamento da educação básica em virtude dos efeitos econômicos adversos da pandemia da COVID-19. Para tanto, são analisados três cenários hipotéticos de queda da arrecadação e seus efeitos para as receitas da educação nos estados e municípios, por meio de um modelo de previsão que combinou dados de receitas de impostos com receitas vinculadas a educação e matrículas. No cenário mais otimista, a redução da receita líquida de impostos de 7% implicaria um decréscimo dos recursos para educação básica de R$ 16,6 bilhões por ano. A receita aluno-mês, que, em 2018, foi de R$ 460,00 em média, poderia cair em proporções que variam entre 4,1% e 26,9%, a depender do cenário de redução e do contexto de cada município. Diante da previsível diminuição de recursos, são propostas medidas urgentes para atenuar o aprofundamento das desigualdades na educação, as quais convergem para a transferência de recursos da União aos governos subnacionais. Finalmente ressalta-se o papel virtuoso do investimento na educação, dada a capilaridade desta e o seu caráter intensivo em pessoal.

Abstract This article aims to estimate the impact of lower tax revenues on the funding of basic education, in the context of the economic impact of the COVID-19 pandemic. Three hypothetical scenarios of lowering tax revenues are estimated and analyzed, along with their effects on the investment in education in the states and municipalities, per-pupil and overall, using a methodology that combines data on tax revenues, mandatory allocation in education, and enrollment numbers. In the most optimistic scenario, the reduction of 7% in the net tax revenues would lead to a decrease in investment in basic education of more than R$ 16.6 billion. The monthly per-pupil expenditure, which in 2018 was R$ 460 on average, could drop between 4.1% and 26.9% depending on which scenario is considered. This probable reduction in revenues requires urgent measures to attenuate the deepening of educational inequalities, converging to the transference of federal funds to sub-national governments. Finally, we highlight the economic virtue of investing in education, when considering the capillarity of education, and its character of intensive investment in personnel.

Resumen El objetivo del artículo es estimar los impactos de la caída de la recaudación tributaria en el financiamiento de la educación básica frente a los efectos económicos adversos de la pandemia de COVID-19. Para ello, se analizan tres escenarios hipotéticos de caída de la recaudación y sus efectos sobre el presupuesto educativo y por alumno en los estados y municipios, por medio de una metodología que combinó datos de ingresos tributarios, recursos impositivos vinculados a la educación y matrículas. En el escenario más optimista, la reducción del 7% de los ingresos tributarios líquidos implicaría una disminución de los recursos para la educación básica de R$ 16,6 mil millones. Los recursos mensuales por alumno que en 2018 fueron de R$ 460,00 en promedio, podrían caer de 4,1% a 26,9%, dependiendo del escenario de reducción. Frente a la previsible disminución de recursos, se proponen medidas urgentes para atenuar la profundización de las desigualdades en la educación, las cuales convergen en la transferencia de recursos federales a los gobiernos subnacionales. Finalmente se resalta el papel virtuoso de la inversión educativa en la economía, dada la capilaridad de la educación y su carácter intensivo en personal.