The neutrophil is an important cell in host defense against infections, acting as the first line of microorganism control. However, this cell exhibits dysregulated activity in sepsis and may contribute to the pathogenesis of the disease. This systematic review aimed to highlight the major scientific findings regarding neutrophil activity in sepsis reported in clinical and experimental research published in the last 10 years. The search was conducted in the Virtual Health Library of PAHO-WHO (BVS) and PubMed databases, and articles published between January 2007 and May 2017 in Portuguese, English, and Spanish were eligible. Article selection was carried out independently by two reviewers (CB and IB). A total of 233 articles were found, of which 87 were identified on PubMed and 146 on BVS. Eighty-two articles were duplicates. Of the remaining 151 articles, 19 met the inclusion criteria after title, abstract, and full-text analysis. Overall, research in clinical samples and animal models of sepsis showed reduced capacity of neutrophils to migrate and delayed apoptosis, but there was no consensus on the phagocytic activity of neutrophils in sepsis. Molecules, such as pentraxin 3 (PTX3), have been analyzed as potential diagnostic markers in sepsis but the diversity of soluble molecules detected in blood samples of sepsis patients did not enable further understanding of the correlation of these circulating molecules with neutrophil activity during sepsis. Optimal understanding of the function of neutrophils in sepsis remains a challenge that, if overcome, would eventually allow targeted therapeutic interventions in patients affected by this severe syndrome.

Acute graft-versus-host disease (aGVHD) and cytomegalovirus reactivation are important complications after allogeneic stem cell transplantation (alloHSCT). Here, we evaluated the impact of treatment with alemtuzumab on the occurrence of aGVHD, cytomegalovirus reactivation and survival after alloHSCT. This was a prospective cohort study conducted at the allo-HSCT unit of Hospital das Clínicas, Universidade Federal de Minas Gerais, Brazil, from January 2009 to December 2011. Fifty-seven patients who underwent alloHSCT were included. Forty-five (79%) patients had a malignant disease. Alemtuzumab was administered before the conditioning regimen at a dose of 1 mg/kg in children and 30 mg/day for 2 days in adults or children weighing more than 40 kg (a total dose of 60 mg) with a non-malignant disease or patients with a malignant disease and high-risk for GVHD mortality. Alemtuzumab was used in 23 (40%) patients, of whom 17 received a reduced-intensity conditioning. Eleven patients presented aGVHD (grade 2–4) and only 1 of them received alemtuzumab. Cumulative incidence of aGVHD (grade 2–4) at day 100 after transplantation (D+100) was 4 for patients receiving alemtuzumab and 29% for patients not receiving alemtuzumab. Cumulative incidence of cytomegalovirus reactivation for patients receiving or not alemtuzumab was 62 and 38%, respectively. Sixteen patients died in the first 100 days after alloHSCT, most of them due to bacterial sepsis. Only 2 patients died of aGVHD until D+100. Overall survival was 50% without any impact of alemtuzumab. Alemtuzumab effectively controlled aGVHD but increased the risk of cytomegalovirus reactivation without improving survival.

The large availability of water vapor at low levels of the atmosphere, advected into the coastal region of Santa Catharina State by the Atlantic Ocean semi-stationary anticyclone, provided the frequent and copious rainfall during the November, 2008. One of the most extreme event occurred in Santa Catharina coastal zone, when a quite strong blocking formed at high levels of the atmosphere is explored processing both, the MM5 and WRF mesoscale models. These models were processed with very high spatial resolution domains, covering the entire region affected by the severe event. The sea surface temperature field revealed that there was a large core on Atlantic waters with quite high temperatures along the coast of Santa Catharina, which enhanced the vertical integrated latent heat supply into the continental region by the winds. The models forecasting results showed consistent results with the observations, as well as an indication that coherences are directly related to the horizontal resolution of the models configurations.

La gran disponibilidad de vapor de agua en los niveles inferiores de la atmósfera, advectada sobre la costa de la provincia de Santa Catarina por el anticiclón semiestacionario del Océano Atlántico, favoreció períodos frecuentes de lluvia durante el mes de noviembre de 2008. La exploración del evento extremo ocurrido en Santa Catarina, que se caracterizó por un intenso bloqueo en niveles altos, se realizó con pronósticos de los modelos del mesoescala MM5 y WRF. Estos modelos fueron procesados con muy alta resolución espacial, abarcando toda la región afectada por el evento severo. La temperatura de la superficie del mar presentaba anomalías positivas de temperatura a lo largo de la costa de Santa Catarina, favoreciendo la transferencia de calor latente hacia la atmósfera, con su posterior advección hacia la zona continental. Los resultados obtenidos con los modelos son consistentes con las observaciones, aunque fuertemente dependientes de la resolución horizontal de los mismos.