The intracranial compliance in type 2 diabetes mellitus (T2DM) patients and the association with cardiovascular autonomic control have not been fully elucidated. The aim of this study was to assess intracranial compliance using the noninvasive intracranial pressure (niICP) and the monitoring of waveform peaks (P1, P2, and P3) and the relationship with cardiovascular autonomic control in T2DM patients. Thirty-two men aged 40-60 years without cardiovascular autonomic neuropathy (CAN) were studied: T2DMG (n=16) and control group CG (n=16). The niICP was evaluated by a noninvasive extracranial sensor placed on the scalp. Cardiovascular autonomic control was evaluated by indices of the baroreflex sensitivity (BRS), from temporal series of R-R intervals of electrocardiogram and systolic arterial pressure, during supine and orthostatic positions. The participants remained in the supine position for 15 min and then 15 min more in orthostatism. T2DMG presented a decrease of the P2/P1 ratio during the orthostatic position (P<0.001). There was a negative moderate correlation between the P2 peak with cardiovascular coupling (K2HP-SAPLF) in supine (r=-0.612, P=0.011) and orthostatic (r=-0.568, P=0.020) positions in T2DMG. We concluded that T2DM patients without CAN and cardiovascular complications presented intracranial compliance similar to healthy subjects. Despite preserved intracranial adjustments, T2DM patients had a response of greater magnitude in orthostatism. In addition, the decoupling between the heart period and blood pressure signal oscillations in low frequency appeared to be related to the worsening of intracranial compliance due to the increased P2 peak.

ABSTRACT Samples of snails were collected in the counties of Miracatu and Eldorado, in Vale do Ribeira, in the State of São Paulo. Infection rates of 5.26% and 1.06%, respectivelly, were obtained in L. columella snails naturally infected by F. hepatica. Infected white mouse eliminated eggs of F. hepatica, in his faeces, 40 days after infection of the animals. Eldorado Ribeira Paulo 526 5 26 5.26 106 1 06 1.06% respectivelly L F hepatica faeces 4 animals 52 2 5.2 10 0 1.06 5. 1.0 1.

RESUMO Exemplares de moluscos colhidos nos municípios de Miracatu e Eldorado, localizados no Vale do Ribeira, Estado de São Paulo, apontam taxas de 5,26% e 1,06%, respectivamente, de infecção natural do molusco Lymnaea columella por formas infectantes de Fasciola hepatica. Utilizando metacercárias obtidas durante a pesquisa, foram inoculados, experimentalmente, via oral, 39 camundongos. Ovos de F. hepatica foram eliminados com as fezes, 40 dias após a infecção. Eldorado Ribeira Paulo 526 5 26 5,26 106 1 06 1,06% respectivamente pesquisa inoculados experimentalmente oral 3 camundongos F fezes 4 52 2 5,2 10 0 1,06 5, 1,0 1,

Tetralogia de Fallot foi diagnosticada em uma fêmea Cocker Spaniel, de 30 meses de idade, por meio de exames físico, radiográfico, eletrocardiográfico e ecocardiográfico. A paciente foi submetida à correção cirúrgica paliativa, técnica de Blalock-Taussig, e em avaliação recente, 46 meses após a cirurgia, apresentava-se sem qualquer manifestação sintomática de descompensação cardiopulmonar.

Tetralogy of Fallot was diagnosed in a 30 month-old Cocker Spaniel female, through physical, radiographic, electrocardiographic, and echocardiographic exams. The animal was submitted to a palliative surgical correction, the Blalock-Taussig technique, and 46 months after the surgery, no signs of cardiopulmonary decompensation were observed.