ABSTRACT The aim of this study was to describe the clinical and morphological characteristics of mixed mammary neoplasms and verify what characteristics affect the prognosis of female dogs with carcinomas in mixed tumors and carcinosarcomas. This was a retrospective study of 67 female dogs that underwent mastectomies and were diagnosed with benign mixed tumors (n=13), carcinomas in mixed tumors (n=44) and carcinosarcomas (n=10). Data regarding the clinical and histological aspects of the neoplasms were collected and the relation with specific survival times, and hazard ratios (HR) in 24 months was calculated. In univariate analysis, the diagnosis of carcinosarcoma (HR 8.26, p=0.006), carcinomatous areas with micropapillary or solid patterns (HR 17.49; p=0. 001) and lymph node metastasis (HR 7.07;p=0.020) were associated with specific survival. In multivariable analysis, only micropapillary or solid pattern (HR=16.34; p=0.007) remained independent factor associated with lower specific survival. Micropapillary or solid carcinomatous patterns were associated with shorter specific survival time (p=0.002) among animals with carcinomas in mixed tumors. Among the carcinosarcomas, lymph node metastasis (p=0.010) was associated with a shorter specific survival time. In conclusion, carcinomas in mixed tumors and carcinosarcomas vary in prognosis depending on the carcinomatous proliferation patterns and spread of the disease. 6 n=13, n13 n n=13 , 13 (n=13) n=44 n44 44 (n=44 n=10. n10 n=10 . 10 (n=10) times HR 2 calculated analysis 826 8 26 8.26 p=0.006, p0006 p p=0.006 0 006 p=0.006) 17.49 1749 17 49 p0 p=0 001 7.07p=0.020 707p0020 7.07 p=0.020 7 07 020 7.07;p=0.020 HR=16.34 HR1634 16 34 (HR=16.34 p=0.007 p0007 007 p=0.002 p0002 002 (p=0.002 p=0.010 p0010 010 (p=0.010 conclusion disease n1 n=1 1 (n=13 n=4 n4 4 (n=4 (n=10 82 8.2 p000 p=0.00 00 17.4 174 p= 07p 7.07p=0.02 707p002 707 7.0 p0020 p=0.02 02 7.07;p=0.02 HR=16.3 HR163 3 (HR=16.3 (p=0.00 p=0.01 p001 01 (p=0.01 n= (n=1 (n= 8. p00 p=0.0 17. 7.07p=0.0 707p00 70 7. p002 7.07;p=0.0 HR=16. HR16 (HR=16. (p=0.0 (n 7.07p=0. 707p0 7.07;p=0. HR=16 HR1 (HR=16 (p=0. 7.07p=0 707p 7.07;p=0 HR=1 (HR=1 (p=0 7.07p= 7.07;p= HR= (HR= (p= 7.07p 7.07;p (p
RESUMO O objetivo deste estudo foi descrever as características clínicas e morfológicas das neoplasias mamárias mistas e verificar quais características interferem no prognóstico de cadelas com carcinomas em tumores mistos e carcinossarcomas. Este foi um estudo retrospectivo de 67 cadelas, que foram submetidas a mastectomias e diagnosticadas com tumores mistos benignos (n = 13), carcinomas em tumores mistos (n = 44) e carcinossarcomas (n = 10). Foram coletados dados sobre os aspectos clínicos e histológicos das neoplasias e a relação com o tempo de sobrevida específica e a razão de risco (OR) em 24 meses foram calculadas. Na análise univariada, o diagnóstico de carcinossarcoma (HR 8,26; p=0,006), as áreas carcinomatosas com padrão micropapilar e sólido (HR 17,49; p= 0,001) e metástase linfonodal (HR 7,07; p=0,020) foram associadas à menor sobrevida específica. Na análise multivariável, apenas o padrão micropapilar ou sólido (HR=16,34; p=0,007) permaneceu como fator independente associado à sobrevida. Proliferações carcinomatosas micropapilares ou sólidas (p = 0,002) foram associadas a tempos de sobrevida específica mais curtos entre os animais com carcinomas em tumor misto. Entre os pacientes com carcinossarcoma, metástases em linfonodos (p = 0,010) foram associadas a um menor tempo de sobrevida específica. Em conclusão, os resultados mostraram que os carcinomas em tumores mistos e os carcinossarcomas podem ter prognóstico variável, dependendo do padrão de proliferação carcinomatosa e da disseminação linfática da doença. 6 n 13, 13 , 13) 44 10. 10 . 10) OR (OR 2 calculadas univariada HR 8,26 826 8 26 p=0,006, p0006 p p=0,006 0 006 p=0,006) 17,49 1749 17 49 0,001 0001 001 7,07 707 7 07 p=0,020 p0020 020 multivariável HR=16,34 HR1634 16 34 (HR=16,34 p=0,007 p0007 007 0,002 0002 002 misto 0,010 0010 010 conclusão variável doença 1 4 8,2 82 p000 p=0,00 00 17,4 174 0,00 000 7,0 70 p=0,02 p002 02 HR=16,3 HR163 3 (HR=16,3 0,01 01 8, p00 p=0,0 17, 0,0 7, HR=16, HR16 (HR=16, p0 p=0, 0, HR=16 HR1 (HR=16 p=0 HR=1 (HR=1 HR= (HR=