ABSTRACT BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) infection is a worldwide concern given its presence even in non-hospitalized healthy individuals, such as university students. OBJECTIVE: To identify in the literature the prevalence of colonization by MRSA among healthcare students. DESIGN AND SETTING: Integrative review of the literature conducted in Universidade Federal do Piauí. METHOD: A search for primary studies was performed in the following databases: Medical Literature Analysis and Retrieval System on-line; Cumulative Index to Nursing and Allied Health Literature; Web of Science; Scopus; and LILACS. RESULTS: This review included 27 studies that demonstrated MRSA infection prevalence ranging from 0.0 to 15.3% among students. CONCLUSION: The prevalence of colonization of MRSA among healthcare students is high, and the nasal cavity was cited as an important reservoir location for these microorganisms.

ABSTRACT BACKGROUND: The pandemic of the new coronavirus has culminated in a scientific race to seek knowledge about this virus and its treatments, vaccines and preventive strategies, in order to reduce its impact on healthcare and economics worldwide. Hence, it is important to recognize the efforts of researchers who are at the forefront of investigations relating to the new coronavirus. OBJECTIVE: The present study was carried out with the aim of analyzing the world scientific production relating to COVID-19. DESIGN AND SETTING: Exploratory and descriptive bibliometric study conducted in the city of Teresina (PI), Brazil. METHOD: ISI Web of Knowledge/Web of Science (WOS) was chosen as the database. Data-gathering was carried out in May 2020. The data analysis was performed using the HistCiteTM software, version 9.8.24, and the VOSviewer bibliometric analysis software, version 1.6.8. RESULTS: 2,625 published papers that included descriptors within the scope of this investigation were identified. These articles were published in 859 different journals that are indexed in WOS, by 9,791 authors who were linked to 3,365 research institutions, located in 105 countries. CONCLUSION: Ascertaining scientific production through a bibliometric analysis is important in order to guide researchers on what has already been produced and what is being researched, so as to be able to address gaps in knowledge through future research.

RESUMO Objetivo Verificar na literatura científica as manifestações sintomáticas da COVID-19 em pessoas adultas. Método Revisão sistemática utilizando as bases Scopus, Web of Science e PubMed com estudos publicados de 1 de dezembro de 2019 a 21 de abril de 2020, a fim de responder à questão norteadora: “Quais as manifestações sintomáticas causada pela COVID-19 em pessoas adultas?” utilizando-se as palavras-chave: “Symptoms”, “Clinical Manifestations”, “Coronavirus”, “COVID-19”. Resultados Do total de 105 referências, foram selecionadas 13 que abordaram as manifestações sintomáticas da COVID-19, estando a febre e a tosse normal ou seca presente em todos os estudos. Conclusão As manifestações sintomáticas identificadas nos pacientes adultos foram: febre, tosse normal ou seca, cefaleia, faringalgia, dispneia, diarreia, mialgia, vômito, escarro ou expectoração, angústia ou dor no peito, fadiga, náusea, anorexia, dor abdominal, rinorreia, coriza ou congestão nasal, tontura, calafrios, dor sistêmica, confusão mental, hemoptise, asma, comprometimento do paladar, comprometimento do olfato, arroto e taquicardia.

ABSTRACT Objective To identify symptoms of COVID-19 in adults in the scientific literature. Method Systematic review of studies published from December 1, 2019 to April 21, 2020 from the Scopus, Web of Science and PubMed databases, in order to answer the following research question: “What are the symptoms caused by COVID-19 in adults?” using the keywords “Symptoms”, “Clinical Manifestations”, “Coronavirus”, “COVID-19”. Results Of the total 105 references, 13 references that addressed the symptoms of COVID-19 were selected. Fever and normal or dry cough were symptoms present in all studies. Conclusion The symptoms identified in adult patients were fever, normal or dry cough, headache, pharyngalgia, dyspnea, diarrhea, myalgia, vomiting, sputum or expectoration, anxiety or chest pain, fatigue, nausea, anorexia, abdominal pain, rhinorrhea, runny nose or nasal congestion, dizziness, chills, systemic pain, mental confusion, hemoptysis, asthma, taste disorder, smell disorder, belching and tachycardia.

RESUMEN Objetivo Verificar en la literatura científica las manifestaciones sintomáticas de COVID-19 en adultos. Método Una revisión sistemática realizada en las bases de datos Scopus, Web of Science y PubMed con estudios publicados del 1 de diciembre de 2019 al 21 de abril de 2020, con el fin de responder a la pregunta orientadora: "¿Cuáles son las manifestaciones sintomáticas causada por COVID-19 en adultos?" utilizando las palabras clave: "Síntomas", "Manifestaciones clínicas", "Coronavirus", "COVID-19". Resultados Del total de 105 referencias, se seleccionaron 13 que abordaron las manifestaciones sintomáticas de COVID-19, con fiebre y tos normal o seca presente en todos los estudios. Conclusión Las manifestaciones sintomáticas identificadas en pacientes adultos fueron: fiebre, tos normal o seca, dolor de cabeza, faringalgia, disnea, diarrea, mialgia, vómitos, esputo o expectoración, angustia o dolor en el pecho, fatiga, náuseas, anorexia, dolor abdominal, rinorrea, secreción nasal o congestión nasal, mareos, escalofríos, dolor sistémico, confusión mental, hemoptisis, asma, alteración del gusto, alteración del olfato, eructos y taquicardia.

Objective: to verify in the scientific literature the symptomatic manifestations of COVID-19 in adults. Method: a systematic review carried out in the Scopus, Web of Science and PubMed databases with studies published from December 1, 2019 to April 21, 2020, in order to answer the guiding question: “What are the symptomatic manifestations caused by COVID-19 in adults?" using the keywords: "Symptoms", "Clinical manifestations", "Coronavirus", "COVID19". Results: Of the total of 105 references, 13 were selected that addressed the symptomatic manifestations of COVID-19, with fever and normal or dry cough present in all studies. Conclusion: the symptomatic manifestations identified in adult patients were: fever, normal or dry cough, headache, pharyngalgia, dyspnoea, diarrhea, myalgia, vomiting, sputum or expectoration, anguish or chest pain, fatigue, nausea, anorexia, abdominal pain, rhinorrhea, runny nose or nasal congestion, dizziness, chills, systemic pain, mental confusion, hemoptysis, asthma, impaired taste, impaired smell, belching and tachycardia

Objetivo: verificar en la literatura científica las manifestaciones sintomáticas de COVID-19 en adultos. Método: una revisión sistemática realizada en las bases de datos Scopus, Web of Science y PubMed con estudios publicados del 1 de diciembre de 2019 al 21 de abril de 2020, con el fin de responder a la pregunta orientadora: "¿Cuáles son las manifestaciones sintomáticas causada por COVID-19 en adultos?" utilizando las palabras clave: "Síntomas", "Manifestaciones clínicas", "Coronavirus", "COVID-19". Resultados: Del total de 105 referencias, se seleccionaron 13 que abordaron las manifestaciones sintomáticas de COVID-19, con fiebre y tos normal o seca presente en todos los estudios. Conclusión: las manifestaciones sintomáticas identificadas en pacientes adultos fueron: fiebre, tos normal o seca, dolor de cabeza, faringalgia, disnea, diarrea, mialgia, vómitos, esputo o expectoración, angustia o dolor en el pecho, fatiga, náuseas, anorexia, dolor abdominal, rinorrea, secreción nasal o congestión nasal, mareos, escalofríos, dolor sistémico, confusión mental, hemoptisis, asma, alteración del gusto, alteración del olfato, eructos y taquicardia.

Objetivo: verificar na literatura científica as manifestações sintomáticas da COVID-19 em pessoas adultas. Método: revisão sistemática utilizando as bases Scopus, Web of Science e PubMed com estudos publicados de 1 de dezembro de 2019 a 21 de abril de 2020, a fim de responder à questão norteadora: “Quais as manifestações sintomáticas causada pela COVID-19 em pessoas adultas?” utilizando-se as palavras-chave: “Symptoms”, “Clinical Manifestations”, “Coronavirus”, “COVID-19”. Resultados: Do total de 105 referências, foram selecionadas 13 que abordaram as manifestações sintomáticas da COVID-19, estando a febre e a tosse normal ou seca presente em todos os estudos. Conclusão: as manifestações sintomáticas identificadas nos pacientes adultos foram: febre, tosse normal ou seca, cefaleia, faringalgia, dispneia, diarreia, mialgia, vômito, escarro ou expectoração, angústia ou dor no peito, fadiga, náusea, anorexia, dor abdominal, rinorreia, coriza ou congestão nasal, tontura, calafrios, dor sistêmica, confusão mental, hemoptise, asma, comprometimento do paladar, comprometimento do olfato, arroto e taquicardia.Palavras-chave: COVID-19. Sintomas Gerais. Manifestações clínicas. Sars CoV-2. Manifestações sintomáticas.