Abstract Splicing, the process that catalyzes intron removal and flanking exon ligation, can occur in different ways (alternative splicing) in immature RNAs transcribed from a single gene. In order to adapt to a particular context, cells modulate not only the quantity but also the quality (alternative isoforms) of their transcriptome. Since 95% of the human coding genome is subjected to alternative splicing regulation, it is expected that many cellular pathways are modulated by alternative splicing, as is the case for the DNA damage response. Moreover, recent evidence demonstrates that upon a genotoxic insult, classical DNA damage response kinases such as ATM, ATR and DNA-PK orchestrate the gene expression response therefore modulating alternative splicing which, in a reciprocal way, shapes the response to a damaging agent.

The Chilean Ministry of Health (MINSAL) led an investigation to identify associated factors to human influenza A (H1N1) infection in turkeys from poultry farms, Valparaíso. The Agriculture and Livestock Farming Service (SAG) informed the detection of influenza A (low pathogenicity) in turkeys and the Public Health Institute (ISP) confirmed influenza A (H1N1).The study included 100% of operative wards: 31% presented positive event (influenza A (H1N1)); 60% if considered only reproductive wards. Dissemination and dispersion velocity of 13 wards in 18 days evidenced a continuous common source. Interviews were performed to 89% of workers of whom 20% presented influenza-like disease: 26% from reproductive wards and 4% from raising and rearing farms. Of15 risk factors studied insemination and age in females showed statistically significant RR in low oviposition index wards. A man-bird transmission is proposed, through direct transmission of saliva during manual insemination or indirect transmission through contaminated semen. To the authors, this is the first turkey 2009 influenza H1N1 outbreak detected worldwide,in this case with a documented cloacal transmission path.

El MINSAL lideró una investigación para identificar factores asociados a infección por influenza A(H1N1) en pavos de planteles avícolas, Valparaíso. El Servicio Agrícola Ganadero informó la detección de influenza A (baja patogenicidad) en pavos y el ISP confirmó influenza A(H1N1). El estudio incluyó 100% de los pabellones operativos: 31% presentó evento positivo (influenza A(H1N1); 60% al considerar sólo pabellones de reproducción. La diseminación y velocidad de dispersión de 13 pabellones en 18 días evidenció una fuente común continua. Se entrevistó a 89% de los trabajadores y 20% presentó ETI: 26% de pabellones de reproducción y 4% de granjas de cría y recría. De 15 factores analizados, inseminación y edad de las hembras mostraron RR estadísticamente significativos en los planteles con baja ovipostura. Se plantea transmisión hombre-ave directa por saliva en inseminación manual o transmisión indirecta por semen contaminado. Es el primer brote de influenza A(H1N1) 2009 en pavos detectado en el mundo y que se comprueba vía de transmisión cloacal.

Objetivo: conocer la evolución a un año de las pacientes a quienes se les ha realizado tratamiento quirúrgico laparoscópico de la endometriosis profunda infiltrante. Metodología: cohorte de 24 pacientes con edades comprendidas entre 22 y 51 años a quienes se les realizó tratamiento quirúrgico de la endometriosis profunda infiltrante en la Unidad de Endoscopia Ginecológica de la Clínica del Prado y Profamilia, en Medellín, entre septiembre del 2007 y febrero del 2008. Se evaluaron las variables sociodemográficas, síntomas dolorosos, localización anatómica de la endometriosis profunda infiltrante, características de la lesión, tratamiento, tiempo quirúrgico, complicaciones. Resultados: se presentó una lesión de recto como única complicación en esta serie (4,1%). Hubo una disminución estadísticamente significativa de los síntomas dolorosos. Tres pacientes (12%) tuvieron recurrencias al año de seguimiento. Conclusión: el tratamiento laparoscópico de la endometriosis profunda infiltrante surge como una alternativa para el tratamiento de la endometriosis infiltrativa profunda.

Objective: making a one-year evaluation of the evolution of patients who underwent laparoscopic surgery for treating deep infiltrating endometriosis. Methodology: a cohort of twenty-four patients aged between 22 and 51 was included; they had had been diagnosed as suffering from deep infiltrating endometriosis. This took place in Clínica del Prado’s gynaecological endoscopy unit and in Profamilia in Medellín between September 2007 and February 2008. Minimally invasive treatment was undertaken with one-year follow-up. The following variables were evaluated: sociodemographic data, painful symptoms, anatomicallocalizationofdeepinfiltrating endometriosis, lesion characteristics, surgical treatment, surgical time and complications. Results: colonic lesion was the only complication reported in this series (4.1%). There was a statistically significant reduction in painful symptoms. Three patients (12%) suffered recurrences during the year-long follow-up. Conclusions: laparoscopic treatment of deep infiltrating endometriosis is an option which alleviates the painful symptoms of endometriosis.