Background: Education on human sexuality was instituted in Eloisa Díaz Campus in 1946. From 2018 an online self-learning general education course on sexuality was started. Aim: To know the degree of knowledge about sexuality and the perception about the course of 586 students (42% women) who approved the course. Material and Methods: The Myths and False beliefs and Self-perception on sexuality tests were applied to students at the onset and the end of the course. They also anonymously evaluated the course. Results: In the first assessment, the proportion of correct answers about sexuality and reproduction were 47 and 40% respectively. In the second assessment, 70% of respondents had open criteria about sexuality and 90% rejected traditional criteria. In the anonymous assessment, 95% estimated that the objectives of the course were accomplished. Its quality was considered good or excellent by 95% of respondents. Conclusions: This course was well accepted by students and corrects their knowledge gaps in sexuality. Despite the social unrest during 2019 and the pandemic during 2020, the course was successfully completed by most students.

ABSTRACT Objective: Odontogenic infection is a common condition in America; the aim of this research was to determine the profile of odontogenic maxillofacial infections and to identify the link between these and the pain felt by patients admitted to the emergency dental service of the Hernân Henriquez Aravena Hospital in Temuco, Chile. Methods: A cross-sectional, double-blind study analysed 49 individuals admitted for emergency dental care. Included were admissions associated with odontogenic infection identified by clinical examination, establishing a relation to pain through a survey. The diagnosis was made clinically using the fascial spaces involved in the infection, presence of self-medication prior to admission, need for surgical treatment and the patient ‘s systemic conditions. The data were analysed using descriptive statistics, Chi-squared, ANOVA, considering a value of p < 0.05 as significant. Results: The average pain level measured by visual analogue scale (VAS) in emergency admission was 8.1. There was no association between the diagnosis (pulp infection, periodontal infection or pericoronitis) and the VAS (p = 0.078), but there was association between age and the diagnosis (p = 0.022), and the VAS was associated with pain compared to other types of pathologies or traumas (p = 0.011). Conclusion: Odontogenic infection is frequent and linked to age and high-pain values. New public policies should be adopted based on these results. New studies are needed to assess new variables associated with these pathologies.

Abstract Pyrazinamide is a prodrug used in infections against Mycobacterium tuberculosis and its resistance is mainly due to mutations in the pncA gene. In this study, the detection of point mutations of this gene was performed in clinical isolates from the State of Nuevo León. Three-dimensional models of the pyrazinamidase enzyme were made by sequencing and using computational tools. The presence of important mutations in eight samples was observed, and in two of them termination codons are shown. The analyzes performed showed that the Q10P and W68S mutations structurally affected the active site. The P62L and D63A mutations occur in an important site; however, the enzyme remains stable. On the contrary, when the S179R mutation is analyzed, the enzymatic function is found to be highly unstable.

Resumen La pirazinamida es un profármaco utilizado en infecciones contra Mycobacterium tuberculosis y su resistencia se debe principalmente a mutaciones en el gen pncA. En este estudio se realizó la detección de mutaciones puntuales de este gen, en aislamientos clínicos del estado de Nuevo León. Se elaboraron modelos tridimensionales de la enzima pirazinamidasa por secuenciación y mediante el uso de herramientas computacionales. Se observó la presencia de mutaciones importantes en ocho muestras, en dos de ellas se presentaron codones de terminación. Las predicciones realizadas mostraron que las mutaciones Q10P Y W68S afectan estructuralmente al sitio activo. Las mutaciones P62L y D63A se presentan en un sitio importante; sin embargo, la enzima permanece estable. Por el contrario, cuando se analiza la mutación S179R se encuentra que la función enzimática es altamente inestable.

Resumen: Este artículo es una síntesis de un proyecto de coinnovación en ganadería familiar desarrollado en el Este de Uruguay por un equipo pluridisciplinario entre marzo 2017 y marzo 2021. La estrategia de intervención, enmarcada en un proceso de investigación-acción participativa, apunta a trabajar en tres espacios: i) el predio ganadero familiar, ii) grupos de productores, y iii) las sociedades de fomento rural. Se apunta a trabajar con 200 productores en forma directa, alcanzando a 650 en forma indirecta. Los resultados obtenidos son los siguientes: i) se han logrado identificar algunos de los principales problemas de las organizaciones y los productores a través de tres talleres de diagnóstico rural participativo en las organizaciones de productores; ii) caracterización del sistema de innovación regional; iii) conformación de tres grupos de productores, realización de 10 jornadas de capacitación; y apoyo a las directivas de las organizaciones; iv) identificación de acciones para la articulación a cadenas de valor, v) puesta en marcha de un dispositivo de seguimiento y evaluación participativo, y vi) avances en el empoderamiento de los productores como sujetos reflexivo-críticos y de acción colectiva (consecuencia de los resultados anteriores).

Abstract: This article presents results of the participatory action research Project “Co-innovation for the sustainable development of the family cattle raising in the Sierras del Este”. The project is financed by the National Institute of Agricultural Research and is implemented by the Agriculture College (Social Sciences Department) and the Agricultural Plan Institute (Extension Agency, east office). Three organizations of producers located in the east region of Uruguay take part in the project. The project begun in 2017 and is expected to finish in 2021. Intervention strategy is based on three key action areas: i) producer farm, ii) group of producers, and iii) organization of producers. Target population covers 200 producers while indirect beneficiaries reach 650 producers. The main results obtained at present are: i) three workshops of participatory rural diagnosis carried out to identify problems, ii) innovation regional system identified, iii) three groups of producers developed, 10 training days carried out, and advisory services to the three organizations, iv) main actions identified to articulation to the value chain, v) implementation of the participatory monitoring and evaluation system, and vi) empowerment of producers as critic, reflective and cooperative persons (this outcome emerges as a consequence of previous results).

Resumo: Este artigo e uma sínteses do projeto Co-innovacion da pecuaria familiar desenvolvido no leste do Uruguai desenvolvido por uma equipe multidisciplinar entre março de 2017 e março 2021. A estratégia de intervenção, enquadrada em um processo de investigação-ação perspectiva, aponta um trabalho em três espaços: i) estabelecimentopecuário familiar ii) grupos de produtores e, iii) sociedades de desenvolvimento rural. O objetivo foi trabalhar com 200 produtores em forma direta, atingindo a 650 em forma indireta. Os resultados obtidos foram: i) a identificação de alguns dos principais problemas das organizações e dos produtores através de três oficinas de diagnóstico rural participativo em organizações de produtores; ii) caracterização do sistema de inovação regional; iii) formação de três grupos de produtores, realização de 10 jornadas de treinamentos, e apoio às diretivas das organizações; iv) identificação de ações para a articulação de cadeias de valor; v) proposta em andamento de um dispositivo de monitoramento e avaliação participativo e; vi) avanços no empoderamento dos produtores como sujeito críticos-reflexivos e de ação coletiva (consequência dos resultados anteriores).

Resumen Este escrito sobre la tabla periódica busca ofrecer ideas para la celebración del Año Internacional de la Tabla Periódica propuesto por la UNESCO para este 2019 y apoyado por diferentes organizaciones a nivel internacional. Tales ideas giran alrededor de la consideración de que el lenguaje científico es el eje articular para enseñarla y aspiran a exponer los aportes de diferentes científicos para lograr lo que hoy conocemos como tabla periódica. Además, se hacen algunas propuestas metodológicas para celebrar este aniversario de forma colectiva o personal. © 2019. Acad. Colomb. Cienc. Ex. Fis. Nat.

Abstract This paper on the periodic table seeks to offer ideas around the celebration of the International Year of the Periodic Table (2019 IYPT) proposed by UNESCO for 2019 and supported by different international organizations. These ideas revolve around the consideration of scientific language as an articulating axis to teach the periodic table and the use of the contributions of different scientists to achieve what we know today as the periodic table. Additionally, we make some methodological proposals to celebrate the 2019 IYPT collectively or in a personal way. © 2019. Acad. Colomb. Cienc. Ex. Fis. Nat.

Abstract: BACKGROUND: Venous thromboembolic disease VTE is a complication that may occur during or after hospitalization. There are few antecedents in our country that evaluate the medical behavior in this subject. OBJECTIVE: To know the prescription related to type, duration and possible causes for omission of thromboprophylaxis in hospitalized patients. MATERIAL AND METHOD: A descriptive, transversal and non-probabilistic study was done, in which from September to November 2016 physicians of Internal Medicine, General Surgery, Intensive Care and Urgency were evaluated through a data collection by questionnaire and presentation of results through descriptive statistics. We also evaluated duration of prescription and dose administered. RESULTS: A total of 556 seconded physicians, 14 service heads, and 234 residents 804 in total were surveyed in seven hospitals in Mexico City belonging to the health system. Thirty percent reported that their hospital has a thromboprophylaxis program; 97.7% consider it safe and 1.2% risky; 96% responded that they prescribe thromboprophylaxis in their patients; 592 73.6% used some clinical prediction scale for VTE; 71% recommended low molecular weight heparin for thrombo prophylaxis and 0.74% administered new generation oral anticoagulants. CONCLUSIONS: Venous thromboembolic disease is potentially preventable; however, prescription shows opportunities for improvement in aspects of pharmacology.

Resumen: ANTECEDENTES: la enfermedad tromboembólica venosa es una complicación que puede manifestarse durante o después de la hospitalización. Existen pocos antecedentes en nuestro país que evalúan el comportamiento médico en este tema. OBJETIVO: conocer la prescripción relacionada con el tipo, duración y posibles causas de la omisión de tromboprofilaxis en pacientes hospitalizados. MATERIAL Y MÉTODO: estudio descriptivo, transversal y no probabilístico en el que de septiembre a noviembre de 2016 se evaluaron médicos de Medicina Interna, Cirugía General, Terapia Intensiva y Urgencias. Se recolectaron datos por cuestionario y presentación de resultados a través de estadística descriptiva. También se evaluó la duración de la prescripción y la dosis administrada. RESULTADOS: se encuestaron 556 médicos adscritos, 14 jefes de servicio y 234 residentes total: 804 de siete hospitales de la Ciudad de México pertenecientes al sistema de salud. El 30% refirió que su hospital cuenta con un programa de tromboprofilaxis; 97.7% la considera segura y 1.2%, riesgosa. El 96% respondió que prescribe tromboprofilaxis en sus pacientes; 592 74% utilizan alguna escala de previsión clínica de enfermedad tromboembólica venosa. El 71% recomienda heparina de bajo peso molecular para tromboprofilaxis y 0.74% administra anticoagulantes orales de nueva generación. CONCLUSIONES: la enfermedad tromboembólica venosa es potencialmente prevenible; sin embargo, la prescripción muestra oportunidades de mejoría en aspectos de farmacología.

Background: Health-related quality of life (HRQOL) refers to individuals' perception of their subjective well-being, considering various aspects of their life and the impact on their health. Aim: To analyze gender differences in the HRQOL of adolescent students in Chile, by age, type of school attended, and area of residence. Material and Methods: Analytical cross-sectional study conducted in a population of 5th and 12th grade students attending municipal, subsidized and private schools in 11 regions of the country. HRQOL was assessed with the KIDSCREEN-52, an instrument that has been previously adapted and validated in Chile. The database obtained from that adaption and validation process was analyzed. Results: In total, 7,910 students (median age 14 years, 53% female) completed the questionnaire. Compared to males, females had lower HRQOL scores in most of the KIDSCREEN-52 dimensions. However, males were more likely to have lower scores in the “Peers and Social Support” and “School Environment” dimensions. These differences remained valid when the sample was stratified by age, type of school, and area of residence were analyzed. Conclusions: This study supports the existence of inequalities in the self-perceived HRQOL of Chilean adolescent students. The existing differences are not only related to gender but are also evident when stratifying by type of school attended.

Background: Rosai Dorfman disease is uncommon and consists in a benign fibrous and hematopoietic tissue proliferation, usually located in the head or neck. It is self-limited and the treatment is the surgical excision of the lesion. Case Report: We report a 69 years old woman consulting for a palpable right breast nodule with a mammography and mammary ultrasound informed as BIRADS 4 and 5, respectively. A core biopsy was informed as a mammary Rosai Dorfman disease. Two years later, due to a lesion growth, the patient was subjected to a partial mastectomy. The pathological study of the surgical piece confirmed the diagnosis of the core biopsy. This disease may resemble a malignant disease and the clue for its diagnosis is the pathological study.

Introducción: La enfermedad de Rosai Dorfman es una entidad infrecuente, que consiste en la proliferación benigna del tejido fibroso y hematopoyético ubicado generalmente en cabeza y cuello. Se trata de una enfermedad benigna, autolimitada, cuyo tratamiento generalmente se limita a la resección quirúrgica, con elevada tasa de recidiva. Objetivo: Exposición de un caso de Enfermedad de Rosai Dorfman mamario, inicial-mente sugerente de patología maligna. caso clínico: Mujer 69 años derivada de atención primaria por nódulo palpable en mama derecha, mamografía y ecografía mamaria BIRADS 4 y 5, respectivamente. Biopsia Core informa Enfermedad de Rosai Dorfman mamaria. A los dos años de diagnóstico se objetiva lesión de mayor tamaño. Se realizó mastectomía parcial con biopsia de pieza quirúrgica compatible con diagnóstico de Biopsia Core previa. Discusión: La similitud clínica de esta enfermedad con patologías malignas mamarias, asociado a su baja prevalencia, dificultan la pesquisa de casos como el expuesto. En los estudios de imágenes raramente se sospecha. La clave del diagnóstico son los hallazgos histológicos en el que característicamente se observa emperipolesis con tinciones inmunohistoquímicas positivas para S 100 y negativo para CD 1. Dado que es una enfermedad benigna y autolimitada su tratamiento generalmente se limita a la resección quirúrgica. Este permite extirpar el tumor en estudio, realizar el diagnóstico, y aliviar la sintomatología producida por el efecto masa de la lesión. A pesar de lo anterior la recidiva es alta, por lo que el seguimiento debe ser a largo plazo.

Background: KIDSCREEN-52, which assesses health related quality of life in adolescents, has been adapted and validated in Chile showing excellent psychometric properties. There is a shorter version of the instrument, whose psychometric properties must be assessed. Aim: To evaluate the psychometric properties of the instrument KIDSCREEN-27 in Chilean adolescents. Material and Methods: A secondary analysis of the database obtained for the adaptation and validation of KIDSCREEN-52. Results: The reliability, calculated through Cronbach’s alpha, for the entire instrument (five dimensions) was 0.89. For physical well-being, psychological well-being, autonomy and relationship with parents and peer social support dimensions, scores were higher than 0.75 while for school environment, the score was 0.69. The confirmatory factor analysis showed that the indices obtained to assess the goodness of fit in this study were a χ2 (314) = 10521.4, a Root Mean Square Error of Approximation = 0.064 and a Comparative Fit index = 0.96. KIDSCREEN-27 scores were higher among men in the physical well-being, psychological well-being, autonomy and relationship with parents dimensions and among women in social support and peers and school environment dimensions. Scores were higher in younger age groups. Conclusions: The Chilean version of KIDSCREEN-27 instrument has adequate reliability and validity.

Palatal fistulas are a common complication of cleft surgery. Options for secondary reconstruction of moderate to large defects are limited due to the scarcity of local donor tissue as well as the scars from the primary cleft repair. We present our experience in the treatment of moderate to large palatal fistulas with facial artery musculo-mucosal flap (FAMM flap), and we describe some technical details that we have introduced to improve safety. We present 8 patients, 5 female and 3 male, aged 5 to 18 years, with congenital cleft palate who developed moderate to large fistulae that after multidisciplinary evaluation were reconstructed with FAMM flap. The sizes of the fistulae ranged from 0,5 to 2,3 cm. in largest diameter. The follow-up was 1-6 years. We obtained a complete correction of palatal fistula in 5 patients without complications. Marginal necrosis occurred in the first 2 cases and required revision. One patient suffered total flap necrosis and required reconstruction with a contralateral FAMM flap. We did not experience complications of the donor site. We consider this flap an excellent option in moderate to large palatal fistula repair because it allows providing a large amount of well vascularized tissue with a wide arc of rotation. After a relatively short learning curve, complications are rare.

Las fístulas de paladar suponen una complicación frecuente en la cirugía de los pacientes fisurados. Las opciones de reconstrucción secundaria en fístulas de tamaño moderado-grande son limitadas por la escasez de tejido donante local y las cicatrices de la palatoplastia. Presentamos nuestra experiencia en el tratamiento de fístulas palatinas moderadas-grandes con colgajo músculomucoso basado en la arteria facial (colgajo FAMM: facial artery musculo-mucosal flap) y describimos algunos detalles técnicos que hemos incorporado para mejorar su seguridad. Revisamos 8 pacientes, 5 mujeres y 3 varones, con edades comprendidas entre los 5 y los 18 años, nacidos con fisura palatina que desarrollaron fístulas palatinas tras la palatoplastia primaria y que tras evaluación multidisciplinaria fueron sometidos a reconstrucción con colgajo FAMM. Los tamaños de las fístulas oscilaron entre los 0,5 y los 2,3 cm. de diámetro mayor. El seguimiento postoperatorio de los pacientes fue de 1 a 6 años. Obtuvimos cierre completo de las fístulas de paladar en el primer tiempo quirúrgico y sin complicaciones en 5 casos. Los 2 primeros sufrieron necrosis de los bordes distales del colgajo y precisaron revisión quirúrgica y una paciente sufrió necrosis total que requirió una nueva reconstrucción con colgajo FAMM contralateral. No hemos registrado complicaciones de la zona donante en ninguno de los casos. Consideramos que el colgajo FAMM es una excelente opción para la reparación de fístulas palatinas de tamaño moderadogrande secundarias a fisura palatina congénita, ya que permite aportar una gran cantidad de tejido vascularizado con un arco de rotación amplio, lo que posibilita obtener resultados de obturación satisfactorios. La tasa de complicaciones, tras una curva de aprendizaje relativamente breve, es baja.

This paper studies the combined effects of temperature, pH and enzyme-substrate ratio (E/S R) on hydrolysis yield and specific reaction rate (S RV) in a microscale iystem in order to maximize enzymatic hydrolysis of pretreated wheat straw (WS). The WS was pretreated by alkaline -peroxide. Enzymatic complex Accellerase 1500TM was used for hydrolysis assays. Using response surface methodology, optimal parameter values were determined. A complete enzymatic kinetic of the hydrolysis reaction was obtained in 10 h. The optimal value of reducing sugars concentration (RSc), given by the model, was 5.97 mg/mL and the corresponding yield was 61.73%. The maximum yield for the WS hydrolysis was 61.73% and was achieved at a temperature of 52.0°C, pH 4.6, and a E/S R of 2.1 mL of Accellerase 1500TM/g of cellulose. The S RV was 4.80 U/mg and was obtained with the following conditions: pH 5.0, temperature of 48.5°C and an E/S R of 0.19 mL/g. A quadratic polynomial equation for predicting the hydrolysis yield was developed. The confirmation experiment showed a final value for RSc of 5.98 ± 0.81 mg/mL. This result indicates a % error of 0.33. The experimental results were in good agreement with predicted value.

El presente trabajo estudia la hidrólisis de paja de trigo utilizando un sistema de microreacción. El Método de Superficie de Respuesta se utilizó para estudiar los efectos combinados de la temperatura, el pH y la relación enzima-sustrato (R E/S) sobre la hidrólisis enzimática y la velocidad específica de reacción V ER. El sustrato fue paja de trigo pretratada de forma alcalino-oxidativa. El extracto enzimático utilizado fue Accellerase 1500TM. El tiempo de obtención de una cinética de la hidrólisis enzimática completa fue de 10 h. El valor óptimo de la concentración de azúcares reductores (C AR) arrojado por el modelo fue de 5.97 mg/mL y el rendimiento correspondiente fue de 61.73%. Estos valores fueron obtenidos con una temperatura de 52.0°C, pH 4.6 y una R E/S de 2.1 mL de Accellerase 1500/g de celulosa. La V ER óptima fue de 4.80 U/mg y fue obtenida con una temperatura de 48.5°C, pH 5.0 y una R E/S de 0.19 mL/g. Se realizó un ensayo de confirmación en el que el valor predicho de C AR por el modelo fue de 5.96 mg/mL y el valor obtenido experimentalmente fue de 5.98 ± 0.81 mg/mL, indicando un error de 0.33%.

Kin selection could provide an explanation for social behavior in bacteria. The production of public goods such as extracellular molecules is metabolically costly for bacteria but could help them to exploit nutrients or invade a host. Some bacterial cells called social cheaters do not produce public goods; however, they take advantage of these extracellular molecules. In this review, the relationships between social behavior, cooperation, and evolution of bacterial pathogenicity are analyzed. This paper also examines the role of horizontal transfer of genes encoding for virulence factors and how the movement of mobile genetic elements would influence the pathogenicity and social relationships. Moreover, the link between ecological relationships and evolution in entomopathogenic bacteria, focusing on Bacillus thuringiensis is considered. Finally, the findings obtained with B. thuringiensis are extrapolated on Bacillus pumilus 15.1, an entomopathogenic strain whose pathogenicity is not understood yet.

Background: KIDSCREEN-52 is an instrument to assess health related quality of life in children and adolescents. Aim: To culturally adapt and validate the KIDSCREEN-52 questionnaire in Chileans. Material and Methods: Two independent translations from the English Spanish language were conciliated and retranslated to English. The conciliated version was tested during a cognitive interview to adolescents of different socioeconomic levels. The final version was validated in 7,910 school attending adolescents. Results: In the cross-cultural adaptation, 50 of the 52 items presented low or medium levels of difficulty and a high semantic equivalence. Distribution according to gender, grades and types of schools was similar to the sample. Single ages were not affected by sex distribution. The Confirmatory Factor Analyses were: X² (1229) = 20996.7, Root Mean Square Error of Approximation = .045 and Comparative Fit Index = .96. The instrument had a Cronbach’s alpha of .93. The domains had scores over 0.70 points, with the exception of the "Selfperception" domain, with a score of 0.62. Conclusions: The Chilean version of KIDSCREEN-52 is culturally appropriate and semantically equivalent in its English and Spanish versions (from Spain). Its reliability and validity were adequate.

São propostas atividades práticas simples para a caracterização de propriedades do som produzido por violões e guitarras através de uma análise harmônica. Entre elas, propomos uma demonstração que pode ser feita em tempo real em sala de aula. Nas atividades desenvolvidas, amostras de som produzidas por instrumentos de cordas são capturadas e analisadas através de uma abordagem espectral. Propriedades físicas da corda do violão e guitarra são exploradas. Os resultados experimentais são comparados com as predições teóricas, com uma concordância excelente. As ferramentas apresentadas podem ser utilizadas como material de apoio no estudo de cordas vibrantes, oscilações, ondas, equações diferenciais, análise harmônica baseada em transformadas de Fourier e instrumentação para o laboratório de física.

Simple practical activities are proposed for the characterization of the sound produced by guitars and electric guitars with a harmonic analysis. Among them, we propose a demonstration that can be carried out in real time at the classroom. In the developed activities, sound samples produced by string instruments are captured and analyzed within a spectral approach. Physical characteristics of the guitar strings are explored. Experimental results are compared with the theoretical predictions, with excellent agreement. The presented tools can be used as support material in the study of vibrating strings, oscillations, waves, differential equations, harmonic analyses based on Fourier transform, and physics laboratory instrumentation.

Objective: To determine the prevalence, the incidence of error, and the potential harm associated to particular prescriptions identified as a risk for medication error in the home treatment of elderly patients admitted to the hospital, as well as factors associated to their occurrence. Material and methods: Cross-sectional, descriptive study. Patients aged 65 years and older, being admitted to the hospital from the emergency department in the last quarter of 2009. The SPSS software version 15.0 was used for the statistical analysis. Results: 324 patients were included in the study. 1,176 (47%) prescriptions were identified as risk prescriptions in 91% of the patients. The most relevant risk prescription was prescription of high-risk medications (51.5% patients) that accounted for an error incidence of 88/100 patients with high-risk medications, being severe in 68 patients. Factors associated to the occurrence of moderate/high risk error due to risk prescriptions were suffering from a chronic respiratory illness, diabetes or polymedication. Conclusions: Actions aimed at decreasing the errors due to high risk medications should be prioritized.

Objetivo: Determinar la prevalencia, la incidencia de error y el daño potencial asociado a determinadas prescripciones señaladas como de riesgo de error de medicación en el tratamiento domiciliario de pacientes ancianos que ingresan en el hospital, así como los factores asociados a su aparición. Material y métodos: Estudio transversal descriptivo. Se incluyeron los pacientes de edad igual o mayor a 65 años que ingresaron en el hospital desde el servicio de urgencias durante el último trimestre de 2009. Para el análisis estadístico se utilizó el programa SPSSv15.0. Resultados: Se incluyeron en el estudio 324 pacientes. Se identificaron 1176 (47%) prescripciones de riesgo en el 91% de los pacientes. La prescripción de riesgo más relevante fue la prescripción de medicamentos de alto riesgo (51.5% pacientes) que presentó una incidencia de error de 88/100 pacientes con medicamentos de alto riesgo, de los cuales en 68 pacientes fue grave. Los factores asociados a la presencia de error grave/moderado ocasionado por prescripciones de riesgo fueron tener enfermedad respiratoria crónica o diabetes y la polimedicación. Conclusiones: Se deben priorizar actuaciones dirigidas a disminuir errores por medicamentos de alto riesgo.