Resumo É descrito o caso grave de uma patologia comum num rapaz saudável de oito anos de idade. O rapaz foi observado em consulta devido a queda de cabelo com sete meses de evolução sem outros sintomas associados, que condicionou grandemente a sua qualidade de vida, fazendo-o utilizar chapéu em todas as situações. Foi estabelecido o diagnóstico de alopecia areata e o rapaz foi submetido a diversos tratamentos ao longo de quatro anos antes de alcançar crescimento capilar completo. Os autores relembram que a alopecia areata pode ser um sinal precoce de uma doença autoimune que poderá manifestar-se apenas anos mais tarde.

Abstract The authors report a severe case of a common disorder in a healthy eight-year-old male child. The boy was observed for asymptomatic hair loss with seven months of evolution that greatly disrupted his life and caused him to wear a hat at all times. Alopecia areata was diagnosed, and the boy underwent four years of multiple treatments before achieving full hair regrowth. It should be noted that alopecia areata can be an early sign of an autoimmune disease that may manifest later with other symptoms.

Resumo Introdujo: Pacientes neurocirúrgicos apresentam elevado risco de complicates locais e sistemicas que podem aumentar o tempo de internado e o risco de morte. Este estudo tem como objetivo avaliar a incidencia de infectes relacionadas a assistencia a saúde e os fatores de risco associados em pacientes submetidos as neurocirurgias. Materiais e Métodos: Estudo de coorte prospectiva, realizado em um Hospital de grande porte do estado de Rondonia, no período de 2018 a 2019, incluindo 36 pacientes. Resultados: A incidencia de infectes relacionada a assistencia a saúde foi 19,4 a cada 100 pacientes (IC95%: 8,19 - 36,02). Ter utilizado sonda nasoenteral aumentou em 6,5 vezes o risco de IRAS (IC 95%: 1,26 - 33,5), a ventilagáo mecánica aumentou 5,52 vezes o risco (IC95%: 1,23 - 24,6), a presenta de traqueostomia aumentou seis vezes (IC95%: 1,34 - 26,8) e realizagáo de exame invasivo aumentou o risco em 6,79 para ter infecto (IC95%: 1,31 - 35,05). Na análise ajustada as variáveis náo apresentaram significáncia estatística. Discussao: A incidencia de infectes foi maior do que em regióes com melhores condigóes socioeconómicas o que pode estar relacionado a menor adesáo de boas práticas na assistencia. Conclusao: Nas neurocirurgias além das infecgóes de sítio cirúrgico outras topografias também devem ser consideradas para investigagáo de infecgáo. O uso de dispositivos invasivos foi associado a ocorrencia de infecgóes relacionadas a assistencia a saúde, portanto as boas práticas no seu uso sáo essenciais no momento da indicagáo e uso destes dispositivos.

Abstract Introduction: Neurosurgical patients are at high risk of local and systemic complications that can increase the length of stay and the risk of death. This study aims to assess the incidence of healthcare-related infections and associated risk factors in patients undergoing neurosurgery. Materials and Methods: prospective cohort study, carried out in a large hospital in the state of Rondonia, in the period from 2018 to 2019, including 36 patients. Results: The incidence of healthcare-related infections was 19.4 per 100 patients (95% CI: 8,19 - 36,02). The use of nasoenteral tube increased the risk of HAI by 6.5 times (95% CI: 1,26 - 33,5), mechanical ventilation increased 5.52 times the risk (95% CI: 1,23 - 24,6), the presence of tracheostomy increased six times (95% CI: 1.34 - 26.8) and invasive examination increased the risk by 6.79 to have infection (95% CI: 1,31 - 35,05). In the adjusted analysis, the variables were not statistically significant. Discussion: The incidence of infections was higher than in regions with better socioeconomic conditions, which may be related to lower adherence to good care practices. Conclusion: in neurosurgeries, in addition to surgical site infections, other topographies should also be considered for investigation of infection. The use of invasive devices has been associated with the occurrence of healthcare-related infections, so good practices in their use are essential when referring and using these devices.

Resumen Introducción: Los pacientes neuroquirúrgicos tienen un alto riesgo de complicaciones locales y sistémicas que pueden aumentar la duración de la estancia y el riesgo de muerte. Este estudio tiene como objetivo evaluar la incidencia de infecciones relacionadas con la atención médica y los factores de riesgo asociados en pacientes sometidos a neurocirugía. Materiales y métodos: estudio de cohorte prospectivo, realizado en un gran hospital del estado de Rondonia, en el período de 2018 a 2019, incluyendo 36 pacientes. Resultados: La incidencia de infecciones relacionadas con la asistencia sanitaria fue de 19,4 por 100 pacientes (IC del 95%: 8,19 - 36,02). Haber utilizado una sonda nasoenteral aumentó el riesgo de infecciones en 6,5 veces (IC 95%: 1,26 - 33,5), la ventilación mecánica aumentó 5,52 veces el riesgo (IC 95%: 1, 23 - 24,6), la presencia de traqueotomía aumentó seis veces (IC del 95%: 1,34 - 26,8) y el examen invasivo aumentó el riesgo en 6,79 de tener infecciones (IC del 95%: 1,31 - 35,05). En el análisis ajustado, las variables no fueron estadísticamente significativas. Discusión: La incidencia de infecciones fue mayor que en las regiones con mejores condiciones socioeconómicas, lo que puede estar relacionado con una menor adherencia a las buenas prácticas de atención. Conclusión: en neurocirugía, además de las infecciones del sitio quirúrgico, también deben considerarse otras topografías para la investigación de la infección. El uso de dispositivos invasivos se ha asociado con la aparición de infecciones relacionadas con la salud, por lo que las buenas prácticas en su uso son fundamentales a la hora de derivar y utilizar estos dispositivos.

ABSTRACT Objectives: Evaluate the celiac disease (CD) markers, within the scope of its screening, in a pediatric population with diagnosis of type 1 diabetes (T1D) at Hospital de Braga (HB) and determine the prevalence of CD in the sample. Reflect on CD screening algorithm applied in this pediatric population. Subjects and methods: Retrospective observational study with 94 patients diagnosed with T1D at age 10 years or younger, followed up at the HB Outpatient Diabetology Consultation, including those referred from other hospitals. Record of clinical information, IgA anti-transglutaminase and anti-endomysium and HLA DQ2/DQ8 haplotypes. Results: We obtained positive serological test for CD in 4 patients. This test had 100% sensitivity and specificity. The prevalence of CD was 4.3% (n = 4). Positive HLA screening in 84.6% of patients, with both sensitivity and negative predictive value of 100% and specificity of 16.67%. Diagnosis of CD was made on average 3.40 ± 3.32 years after the diagnosis of TD1. All cases of CD registered non-gastrointestinal manifestations, none had gastrointestinal symptoms. Conclusion: This study proved that there is a higher prevalence of CD in pediatric population with TD1, when compared to general population, and clarified the importance of CD screening. Furthermore, it was observed that serological screening for CD antibodies is an excellent screening test and HLA typing, although not the most suitable first line test, can be useful in excluding the possibility of patients with T1D developing CD.

Introdução: A diabetes mellitus tipo 1 é uma das doenças endócrinas mais comuns em idade pediátrica e implica um tratamento contínuo e rigoroso, com impacto na qualidade de vida das crianças e adolescentes afetados. O objetivo deste estudo foi avaliar a qualidade de vida de adolescentes com diabetes mellitus tipo 1 e a sua relação com aspetos clínico-laboratoriais e estilos de vida. Material e Métodos: O questionário DQOL foi aplicado a adolescentes com diabetes mellitus tipo 1 seguidos em consulta de Diabetologia Pediátrica de um hospital de nível II há mais de um ano. O questionário tem uma pontuação global entre 36-180, com maior pontuação a refletir pior qualidade de vida. A análise estatística foi efetuada no software SPSS®. Resultados: Responderam ao inquérito 71% (n=36) dos adolescentes, 55,6% dos quais do sexo masculino, com uma mediana de idades de 15 anos. A mediana de pontuação global no DQOL foi 66. Os adolescentes com bom controlo metabólico tiveram uma mediana de pontuação global de 49 em comparação com 71 no grupo com mau controlo metabólico (p=0,007). A pontuação global mediana de auto-perceção de melhor saúde foi 51 em comparação com 73 para a auto-perceção de pior saúde (p=0,007). Discussão: No geral, os adolescentes deste estudo revelaram uma boa qualidade de vida. Adolescentes com melhor controlo metabólico têm maior satisfação e melhor qualidade de vida e adolescentes com melhor auto-perceção de saúde têm melhor qualidade de vida. Conclusão: Reconhecer os fatores que afetam a qualidade de vida dos adolescentes com diabetes mellitus tipo 1 é fundamental para delinear estratégias terapêuticas que vão de encontro às suas expectativas, promovendo a adesão à terapêutica e um melhor controlo metabólico.

Introduction: Type 1 diabetes mellitus is one of the most common endocrine-metabolic disorders of childhood and adolescence and requires a continuous and rigorous therapeutic approach, with recognized impact on children and adolescents’ quality of life. The purpose of this study was to evaluate the quality of life of adolescents with type 1 diabetes mellitus and its relationship with clinical and laboratory aspects and lifestyle. Material and Methods: DQOL questionnaire was applied to type 1 diabetes mellitus adolescents managed at the Pediatric Diabetology consultation of a level II hospital for more than one year. Questionnaire has a global score between 36 and 180, with higher scores reflecting worse quality of life. Statistical analysis was performed in SPSS®. Results: Seventy-one percent (n=36) of adolescents responded to the survey, 55.6% of which male, with a median age of 15 years. Median DQOL global score was 66. Adolescents with good metabolic control had a median global score of 49, compared with 71 in adolescents with poor metabolic control (p=0.007). The median global score of self-perception of better health was 51 compared to 73 for self-perception of poorer health (p=0.007). Discussion: In general, adolescents in this study revealed a satisfactory quality of life. Adolescents with better metabolic control have a higher satisfaction and better quality of life. Adolescents with better self-perceived health have a better quality of life. Conclusion: Recognizing factors that affect quality of life of adolescents with type 1 diabetes mellitus is crucial to devise therapeutic strategies that meet their expectations, promoting treatment adherence and better metabolic control.

Introduction: Ovarian torsion can occur at any pediatric age, mainly between the ages of 9 and 14 years. Diagnosis is challenging, as symptoms are nonspecific, misleading to other more common diagnoses, as genitourinary and gastrointestinal disorders. In children, ovarian lesions leading to torsion are typically benign and cystic. Surgical approach is safe, as most cases of early torsed ovary untwisting exhibit later normal ovarian function. Case report: A 13-year-old female adolescent was referred to the Emergency Department for vomiting, left low back pain, and diffuse abdominal pain with irradiation to the hypogastric area, associated with urinary symptoms. Abdomen was tender in the right iliac fossa and hypogastric area. Analytical study revealed increased inflammatory parameters, urinary test strip was negative, and pelvic computed tomography showed a cystic lesion of ovarian origin. Due to suspicion of cyst torsion, laparoscopic surgery was performed, revealing a necrotic adnexal torsion requiring adnexectomy. Discussion: Although often suspected, adnexal torsion is rarely confirmed. Although ovarian torsion accounts for a small number of all gynecological emergencies, it represents a common diagnostic challenge in the emergency setting. Conclusion: As ovary viability depends on early diagnosis, a high index of suspicion is required. This clinical case raises awareness of this entity in the differential diagnosis of lower abdominal pain in female children and adolescents.

The feasibility of obtaining cellulose acetate from lignocellulosic precursors is of great interest from the environmental, economic and technological points of view. Herein, sugarcane bagasse and vegetable sponge (Luffa cylindrica ) were used as precursors to produce cellulose using the organosolv extraction procedure. From the extracted celluloses, the production of cellulose acetate was carried out by the homogeneous acetylation method. The obtained materials were characterized by FTIR, solid-state 13C NMR, XRD, TG and DSC techniques. The results revealed the success of both the extraction and the acetylation processes, which provided cellulose with high crystallinity and cellulose acetates with high degrees of substitution (cellulose triacetates).

Introdução: A Diabetes Mellitus tipo 1 é uma das doenças crónicas mais prevalentes na infância e adolescência. A apresentação da doença é variável, dependendo da duração dos sintomas e da idade da criança. Caso Clínico: Os autores descrevem o caso de uma criança de 30 meses avaliada em consulta de Pediatria por perda de competências cognitivo-comportamentais e estagnação das aquisições motoras, tendo sido diagnosticada uma Diabetes Mellitus tipo 1 inaugural, sem acidose. Após a melhoria do controlo glicémico com a insulinoterapia, verificou-se uma normalização progressiva do neurodesenvolvimento da criança. Discussão/ Conclusão: Este caso ilustra uma apresentação incomum da Diabetes Mellitus tipo 1. A fisiopatologia das alterações neurológicas agudas associadas à Diabetes Mellitus tipo 1 ainda não está totalmente esclarecida. Um controlo glicémico eficaz é benéfico para o adequado neurodesenvolvimento das crianças com Diabetes.

Introduction: Type 1 Diabetes Mellitus is one of the most prevalent chronic diseases in childhood and adolescence. Disease presentation is diverse, depending on the duration of symptoms and the age of onset. Case report: A 30-month-old child was referred to the Paediatric Outpatient Clinic for loss of cognitive and behavioural skills and stagnation of motor abilities occurring in the last six months, weight loss and polydipsia during the previous month. The child was diagnosed with inaugural type 1 Diabetes Mellitus without acidosis. Management of the disease, through glycaemic control with insulin therapy was associated with progressive improvement of the child’s neurodevelopment. Discussion/Conclusion: This case illustrates an unusual presentation of type 1 Diabetes. The mechanisms underlying acute neurological changes associated with type 1 Diabetes are not yet completely clarified. An efficient glycaemic control benefits an adequate neurodevelopment of children with Diabetes.

Introdução: O atraso pubertário é uma patologia frequente na consulta de Endocrinologia. Várias doenças podem estar subjacentes a este problema, sendo a doença inflamatória intestinal, mais concretamente a doença de Crohn, uma das doenças crónicas mais associadas. Caso clínico: Adolescente, sexo feminino, de 16 anos, sem antecedentes patológicos relevantes, referenciada à consulta de Pediatria por atraso pubertário com amenorreia primária e má evolução estaturo-ponderal. Inicialmente sem qualquer sintomatologia digestiva. Posteriormente iniciou queixas gastrointestinais, tendo sido submetida a estudo analítico, endoscópico e radiológico, que permitiu o diagnóstico de doença de Crohn com atividade moderada-grave. Iniciou-se tratamento de indução de remissão com corticosteroides e tratamento de manutenção com infliximab, com melhoria significativa dos sintomas e evolução pubertária favorável. Discussão/Conclusão: Pretende-se relembrar a doença de Crohn como uma das causas de atraso de crescimento e pubertário, salientando-se a necessidade de um diagnóstico precoce com instituição atempada de terapêutica, de modo a ser possível uma evolução pubertária favorável.

Background: Pubertal delay is a common condition in the Endocrinology clinic. Many diseases can underlie this phenomenon, being inflammatory bowel disease, namely Crohn ’s disease, one of the most commonly related chronic diseases. Case report: Sixteen-years-old female adolescent, with no previous medical history, was referred to the Pediatric clinic because of pubertal delay with primary amenorrhea and failure to thrive. She had initially no digestive symptoms. She subsequently developed gastrointestinal complaints. Laboratorial, endoscopic and radiological studies that allowed the diagnosis of moderate to severe Crohn’s disease. Discussion/Conclusion: We aimed to aware Crohn’s disease as one of the causes of pubertal and growth delay, highlighting the need for early diagnosis and therapy, in order to reach a favorable pubertal development.

Introdução: A Síndrome do Ovário Poliquístico é a endocrinopatia mais frequente nas mulheres em idade reprodutiva. As manifestações começam habitualmente durante a adolescência; porém o diagnóstico nesta faixa etária é dificultado pela sobreposição das características da síndrome e os achados fisiológicos observados durante a progressão normal da puberdade. Objetivos: Rever a abordagem diagnóstica e terapêutica da Síndrome do Ovário Poliquístico na adolescência. Desenvolvimento: Não existem critérios de diagnóstico ou orientações terapêuticas consensuais para a Síndrome do Ovário Poliquístico na população pediátrica. Por outro lado, algumas das manifestações da síndrome, como a acne, irregularidades menstruais e hiperinsulinemia, são achados normais durante a puberdade. A maioria dos autores sugere um diagnóstico baseado na evidência clínica e/ou laboratorial de hiperandrogenismo associada a disfunção ovárica, não explicada por outras etiologias. O doseamento sérico da testosterona livre é o método mais sensível e fiável para a documentação do hiperandrogenismo bioquímico. Já a visualização ecográfica dos ovários poliquísticos, não estabelece o diagnóstico, pois trata-se de um achado frequente em adolescentes saudáveis. A abordagem terapêutica assenta essencialmente na mudança do estilo de vida e no tratamento do hirsutismo/irregularidades menstruais. Conclusões: A identificação das adolescentes em risco para o desenvolvimento da Síndrome do Ovário Poliquístico é fundamental. Para além de uma abordagem terapêutica adequada, é primordial prevenir as co morbilidades associadas à síndrome, entre elas a obesidade, insulinorresistência, dislipidemia e infertilidade.

Introduction: Polycystic Ovary Syndrome is recognized as the most common endocrine disorder of reproductive-age women. The syndrome often presents during adolescence, but the diagnosis in this age group is complicated by the overlap between features of the syndrome and physiologic findings observed during the normal progression of puberty. Objective: To review the diagnosis and treatment of Polycystic Ovary Syndrome in adolescence. Development: There are no consensual diagnostic criteria or treatment guidelines for Polycystic Ovary Syndrome in pediatric population. Many features of the syndrome, including acne, menstrual irregularities and hyperinsulinemia, are common in normal puberty. Most authors recommend a diagnosis based on clinical and/or biochemical evidence of hyperandrogenism with ovarian dysfunction, not explained by other causes. Measurement of free testosterone level is the more sensitive and reliable method for establishing the existence of androgen excess. Ultrasonographic visualization of polycystic ovary doesn’t set the diagnosis, because it’s a frequent finding in healthy adolescents. Lifestyle changes and treatment of hirsutism and menstrual irregularities are essential hallmarks in the therapeutic approach of Polycystic Ovary Syndrome in adolescents. Conclusion: Identification of adolescents at risk for Polycystic Ovary Syndrome is critical, not only for an appropriate therapeutic approach, but also to prevent co-morbidities associated with the syndrome, including obesity, insulin resistance, dyslipidemia and infertility.

The aim of this study was to produce membranes using the adapted cuprammonium method. The cellulose utilized was obtained from recycled agroindustrial residues: sugarcane bagasse, corn stover and soybean hulls. The levels of Cu (II) ions in regenerated cellulose membranes produced with cellulose from bagasse, corn stover and soybean hulls were 0.0236 wt%, 0.0255 wt% and 0.0268 wt%, respectively. These levels were approximately 15 times lower than those observed in previous studies (0.3634 wt%). Cellular viability data show that membranes produced from bagasse cellulose do not present toxicity to the cellular cultures studied. These results demonstrate an evolution in production of regenerated cellulose membranes from agroindustrial residues mainly due to a decrease in the Cu (II) ions level, showing the possibility of application of these systems with improved membranes processing.

Cellulose acetates (CA) with different degrees of acetylation were synthesized from cellulose extracted from corn stover. Membranes were prepared for the ultrafiltration process with pure polymers and blend form of CA utilizing a dioxane/acetone system. The membranes were characterized according to their transport properties. The blend form materials presented the best results for application in ultrafiltration experiments. M-TAC/DAC (corn stover triacetate and diacetate) and M-TAC/DAC-Rho (corn stover triacetate and Rhodia diacetate) presented rejection to egg albumin protein of 87.39% and 80.50%, respectively. Thus, MWCO of 45 kDa was determined for these materials.

Introdução: Os principais diagnósticos a considerar numa febre de etiologia indeterminada incluem as causas infecciosas, reumatológicas, imunológicas e neoplásicas. Caso clínico: Apresentamos o caso de uma criança de quatro anos do sexo masculino, observada por febre, cervicalgia e claudicação da marcha. Detectou-se anemia e marcadores inflamatórios elevados. No internamento foi-se evidenciando palidez, exantema maculo-papular em pico febril e adenomegalias cervicais. A avaliação por Cardiologia evidenciou ectasia coronária, tendo iniciado imunoglobulina intravenosa (IGIV) por suspeita de Doença de Kawasaki atípica (DKa). Por persistência da febre invocou-se o diagnóstico mais provável de Artrite Idiopática Juvenil sistémica (AIJs). Discussão: Após a exclusão de outras causas, o diagnóstico diferencial entre DKa e AIJs é difícil pela inespecificidade dos achados. A suspeita de DKa, justifica a terapêutica com IGIV, mas a refractariedade a esta não a exclui (10% de casos refractários). Por outro lado, está descrita a presença de dilatações coronárias em contexto de quadro inflamatório sistémico, tornando este achado sugestivo mas não patognomónico de Doença de Kawasaki.

Background: The most common causes of fever of unknown origin are infectious diseases, rheumatologic or immunologic diseases, and malignancies. Case report: The case of a four years old male child with fever, neck pain and limping gait is presented. He was anemic and had elevated inflammatory markers. He developed gradual pallor, maculopapular rash appearing with fever peaks, and cervical lymphadenopathy. Echocardiographic documentation of coronary artery ectasia, lead to intravenous immunoglobulin (IVIG) therapy for suspected atypical Kawasaki disease (aKD). The most probable diagnosis of systemic-onset Juvenile Idiopathic Arthritis (sJIA) was made after fever maintenance. Discussion: It is difficult to differentiate between aKD and sJIA because there are no specific findings. The suspicion of aKD should lead to IVIG therapy, but failure to respond is not an exclusion criterion (10% of patients are refractory cases). Systemic inflammatory disorders, like sJIA, may be associated with coronary artery dilation. This finding supports a diagnosis of aKD but is not specific for the condition.

Membranas de poliamidas alifáticas são muito utilizadas como barreiras seletivas em processos de microfiltração e ultrafiltração. Neste trabalho membranas de poliamida 66 (PA 66) foram preparadas pelo método de inversão de fases e caracterizadas para aplicação em processos de ultrafiltração. As membranas de PA 66 foram preparadas utilizando dois solventes diferentes, ácido fórmico (AF) e ácido clorídrico (HCl) e água como não-solvente. A análise por Espectroscopia de Infravermelho com Transformada de Fourier (FT-IR) mostrou que a estrutura química da PA 66 não foi alterada com o uso dos solventes na preparação das membranas. O ensaio de compactação com água pura realizado a 1500 kPa de pressão revelou que as membranas preparadas em AF sofreram maior compactação na sua estrutura apresentando fluxo de permeado em torno de 17 L.m-2.h-1 enquanto a membrana preparada em HCl apresentou fluxo de 22,2 L.m-2.h-1. Nos ensaios de ultrafiltração (UF), ambas as membranas apresentaram valores de retenção próximos a 70% para albumina de ovo (45 kDa) e 80% para albumina sérica bovina (69 kDa). Com esse resultado, pode-se concluir que ambas as membranas apresentaram ponto de corte nominal para aplicações em processos de UF.

In the present study, polyamide 66 (PA 66) membranes were prepared by phase inversion method and characterized in order to verify their potential application in ultrafiltration processes. PA 66 membranes were prepared using two different solvents, formic acid (FA) and hydrochloric acid (HCl), and water as a non-solvent. Fourier-transform infrared spectroscopy (FT-IR) showed that the chemical structure of PA 66 was not altered by the use of solvents in the preparation of membranes. The compaction experiment with pure water performed at a pressure of 1500 kPa revealed that membranes prepared with FA undergo greater compaction of its structure and had a permeate flux value of approximately 17 L.m-2.h-1 whereas the membrane prepared with HCl had a permeate flux of 22.2 L.m-2.h-1. In the ultrafiltration experiment, both membranes had retention values around 70% for egg albumin and 80% for bovine serum albumin. Based on this result, one concludes that both membranes had nominal cut off values for application in ultrafiltration processes.

Methylcellulose was produced from the fibers of Mangifera indica L. Ubá mango seeds. MCD and MCI methylcellulose samples were made by heterogeneous methylation, using dimethyl sulfate and iodomethane as alkylating agents, respectively. The materials produced were characterized for their thermal properties (DSC and TGA), crystallinity (XRD) and Degree of Substitution (DS) in the chemical route. The cellulose derivatives were employed as mortar additive in order to improve mortar workability and adhesion to the substrate. These properties were evaluated by means of the consistency index (CI) and bond tensile strength (TS) tests. The methylcellulose (MCD and MCI) samples had CI increased by 27.75 and 71.54% and TS increased by 23.33 and 29.78%, respectively, in comparison to the reference sample. Therefore, the polymers can be used to produce adhesive mortars.

Cellulose acetate produced from mango seed fibers cellulose was used as a matrix for preparation of microparticles empty and load with acetaminophen (Paracetamol) in order to evaluate the incorporation of an active agent during the formation of microparticles. The microparticles are characterized by Fourier Transformed Infrared spectroscopy (FTIR), Differential Scanning Calorimetry (DSC) and Scanning Electron Microscopy (SEM). The incorporation of paracetamol can be confirmed by the change in value of glass transition temperature (Tg). The formation of microparticles spherical was observed by SEM and showed an average diameter of 1.010 and 0.950 mm for empty and load microparticles respectively.