In this work we described the synthesis and characterization of a series of novel chiral 1,5-diamines derived from (R)-(+)-camphor through simple procedures in moderate to good yields. These new enantiopure compounds constitute a new family of chiral diamines with potential applicability as chiral building blocks, bioactive products or chiral ligands for asymmetric transformations. 1,5diamines 15diamines 1,5 1 5 R+camphor Rcamphor R + camphor yields blocks transformations 5diamines 15 1,

An enantioselective six-step synthesis of (1S,2R)-ephenamine starting from readily available chiral amino acid is disclosed presenting 26% overall yield and high optical purity. The use of chiral phenylglycine as starting material was also studied and did not present satisfactory results due to a very sensitive a-carbonyl/benzylic stereogenic center that, in our hands, led to racemization.