Resumo O espraiamento recente das plataformas digitais tem provocado novas dinâmicas da relação entre trabalho e cidade. O objetivo deste artigo é analisar os fluxos urbanos dos entregadores de aplicativos pela metrópole de São Paulo para explorar empiricamente as condições em que esse trabalho se inscreve na cidade. Argumentamos que a dispersão de milhares de trabalhadores pela metrópole, ancorada por uma gestão algorítmica, somente se realiza por um controle incisivo do tempo, do território e do próprio trabalho e pela intensa vulnerabilidade dos trabalhadores. Mobilizando dados obtidos por meio de incursões etnográficas, entrevistas e elaboração de material cartográfico, buscaremos discutir as dinâmicas de (re)produção das desigualdades centro-periferia de um trabalho que se espacializa sob gestão centralizada das empresas de plataforma. cidade algorítmica tempo etnográficas cartográfico reprodução re produção centroperiferia centro periferia plataforma

Abstract The recent spread of digital platforms has produced new dynamics in the relationship between work and the city. The aim of this article is to analyze urban flows of app-based delivery workers in the São Paulo metropolis to explore empirically the conditions under which this work is inscribed in the city. We argue that the dispersion of thousands of workers throughout the metropolis, supported by an algorithmic management, can only be carried out through an incisive control of time, territory, and of the work itself, as well as through the workers’ intense vulnerability. Using data obtained by means of ethnographic incursions, interviews, and by the development of cartographic material, we seek to discuss the dynamics of (re)production of central-peripheral inequalities along with work that is spatialized under the centralized management of platform companies. city appbased app based time territory itself vulnerability incursions interviews material reproduction re production centralperipheral central peripheral companies

ABSTRACT This article aims to answer the question: Is intellectual giftedness in human beings, when compared to the normal intelligence of individuals, associated with the experience of depression or depressive disorder? Considering the results of five databases (PsycInfo, Web of Science, Scopus, SciELO and PubMed) and inclusion and exclusion criteria, depression in gifted individuals is related to: self-esteem (n = 4); internalizing behaviors (n = 2); stress (n = 4); protective and/or risk factors (n = 5); suicidal ideation (n = 2); perfectionism (n = 3); emotional adjustment (n = 6). The diversity of criteria for giftedness or psychometric tests used restricts the possibility of conclusion; however, points of convergence are observed. In the one hand, three studies found that the gifted were less depressed than average-achieving students, one article found the opposite. One study confirms the proposition that girls are more depressed than boys in the same condition. On the other hand, the results of two articles demonstrate that, among the gifted, boys are more depressed than girls. It is postulated that a future meta-analysis will be carried out in order to measure the significance and effect size of each result.

RESUMO Este artigo tem como objetivo responder à pergunta: A superdotação intelectual em seres humanos, quando comparada à inteligência normal de indivíduos, está associada à experiência de depressão ou de transtorno depressivo? Considerando resultados de cinco bases (PsycInfo, Web of Science, Scopus, SciELO e PubMed) e critérios de inclusão e de exclusão, relaciona-se a depressão em superdotados: à autoestima (n = 4); a comportamentos internalizantes (n = 2); ao estresse (n = 4); a fatores de proteção e/ou risco (n = 5); à ideação suicida (n = 2); ao perfeccionismo (n = 3); ao ajustamento emocional (n = 6). A diversidade de critérios para superdotação ou de testes psicométricos utilizados restringe a possibilidade de conclusão; contudo, observam-se pontos de convergência. Por um lado, três estudos revelaram que os superdotados eram menos deprimidos do que os alunos de desempenho normal, e um artigo revelou o contrário. Um estudo ratificou a proposição de que meninas são mais deprimidas do que meninos na mesma condição. Por outro lado, os resultados de dois artigos demonstraram que, entre os superdotados, meninos são mais deprimidos do que meninas. Postula-se a realização de futura metanálise a fim de mensurar a significância e o tamanho do efeito de cada resultado.

In this study, the interaction between benzothiazole (BTA, concentration of a drug required for 50% inhibition in vitro (IC50) = 0.77 mM) and benzimidazole (BIA, IC50 = 2.14 mM) with urease was quantitatively assessed, using UV-Vis, molecular fluorescence, and circular dichroism. The results showed that both compounds interact with urease by a static fluorescence quenching mechanism with a non-fluorescent complex formation. The main forces responsible for stabilizing the supramolecular complex between BTA and urease were hydrophobic while, for BIA, van der Waals interactions and hydrogen bonds were the main ones. Urease conformation changes due to the interaction process were analyzed by circular dichroism and synchronous fluorescence. Besides, a competitive assay with substrate and inhibitors was used to evaluate the preferential urease site of interaction with BTA and BIA. Our experimental and theoretical studies supported that both, BTA and BIA, are mixed-inhibitors of ureases with a slight preference to the active site of such enzymes. Finally, both BTA and BIA showed to possess anti-Helicobacter pylori (one reference strain and six clinical isolates) activity, presenting minimal inhibitory concentration (MIC) values ranging from 38-150 and 20-164 µM, respectively. The urease inhibitors omeprazole and hydroxyurea showed MIC values in the range of 46-185 µM and 1683-> 3366 µM, respectively.

RESUMO Objetivo: investigar como as escalas para o conceito de virtudes morais são construídas e mensuradas, em estudos associados à ética empresarial e à tradição da ética das virtudes. Métodos: realizou-se uma revisão sistemática da literatura para selecionar artigos empíricos sobre virtudes morais que elaboram ou aplicam escalas. Com base em critérios de busca, seleção e análise, foram consultadas cinco bases de dados e selecionados 37 trabalhos, analisando-se o procedimento de desenvolvimento e mensuração de escalas (itens, amostra, análise fatorial) e fatores emergentes. Resultados: o estudo reúne escalas de múltiplas virtudes morais (19) e de virtudes específicas (18), evidenciando limitações na geração de itens e na proporção item-amostra em algumas escalas, como também contribuições teóricas em liderança e fortalecimento de relações, fazendo uma discussão teórico-metodológica, à luz dos pressupostos da ética das virtudes na tradição aristotélico-tomista. Conclusões: o artigo intenciona contribuir para uma melhor compreensão sobre as virtudes morais em administração, ao discutir as escalas a partir da unidade das virtudes e da conexão phronesis-virtudes morais, com implicações no comportamento humano e na ética empresarial. Recomendam-se procedimentos para estudos futuros qualitativos e quantitativos em novos contextos de pesquisa.

ABSTRACT Objective: to investigate how scales for the concept of moral virtues are constructed and measured, in studies associated with business ethics and the tradition of virtue ethics. Methods: a systematic literature review was conducted to select empirical articles on moral virtues that design or apply scales. Based on search, selection, and analysis criteria, five databases were consulted, and 37 papers were selected, with subsequent analysis of the scales development and measurement procedure (items, sample, factor analysis) and emerging factors. Results: the study gathers scales of multiple moral virtues (19) and of specific virtues (18), showing limitations in the generation of items, and in the item-sample proportion in some scales, as well as theoretical contributions in leadership and relationship strengthening, making a theoretical and methodological discussion in the light of the assumptions of virtue ethics in the Aristotelian-Thomistic tradition. Conclusions: the article intends to contribute to a better understanding of moral virtues in management, by discussing the scales from the unity of virtues and the phronesis-moral virtues connection, with implications for human behavior and business ethics. Procedures are recommended for future qualitative and quantitative studies in new research contexts.

RESUMO O presente estudo teve como objetivo a análise do lançamento de disco em atletas paralímpicos de duas classes funcionais (CFs). Sete atletas de duas classes F-44 (N=4) e F-46 (N=3) executaram 3 lançamentos cada durante uma competição regional, e foram avaliados por meio de cinemetria 3D. Os atletas avaliados apresentaram uma técnica de lançamento semelhante, com movimento de preparação em direção oposta ao lançamento que antecedia o arremate. Na classe F-44 houve uma fraca correlação entre a velocidade de decolagem e o alcance do disco (r= 0,15; p>0,05). Na F-46 houve forte correlação entre a velocidade de decolagem e o alcance (r= 0,77; p=0,014). Conclui-se que atletas das CFs avaliadas apresentam diferenças importantes em termos de desempenho.

ABSTRACT This study aimed to analyze discus throwing in Paralympic athletes from two functional classes (FCs). Seven athletes from two classes F-44 (N=4) and F-46 (N=3) performed three throws each during a regional competition and were evaluated through 3D kinemetry. The assessed athletes presented a similar throwing technique, with a preparation movement opposite to the throw preceding the shot. Class F-44 showed a weak correlation between take-off speed and range (r= 0.15; p>0.05). F-46 showed a strong correlation between take-off speed and range (r=0.77; p=0.014). We conclude that athletes from the assessed FCs present important differences in terms of performance.

RESUMEN El presente estudio tuvo como objetivo analizar el lanzamiento de disco en atletas paralímpicos de dos clases funcionales (FC). Siete atletas de dos clases F-44 (N = 4) y F-46 (N = 3) realizaron 3 lanzamientos cada uno durante una competencia regional, y fueron evaluados usando cinemetría 3D. Los deportistas evaluados presentaron una técnica de lanzamiento similar, con un movimiento de preparación en sentido contrario al lanzamiento que precedió al tiro. En la clase F-44 hubo una correlación débil entre la velocidad de despegue y el alcance del disco (r = 0,15; p> 0,05). En el F-46 hubo una fuerte correlación entre la velocidad de despegue y el alcance (r = 0,77; p = 0,014). Se concluye que los deportistas de los CF evaluados presentan importantes diferencias en cuanto a rendimiento.

Abstract The current COVID-19 pandemic has already claimed more than 3.7 million victims and it will cause more deaths in the coming months. Tools that track the number and locations of cases are critical for surveillance and help in making policy decisions for controlling the outbreak. However, the current surveillance web-based dashboards run on proprietary platforms, which are often expensive and require specific computational knowledge. We developed a user-friendly web tool, named OUTBREAK, that facilitates epidemic surveillance by showing in an animated graph the timeline and geolocations of cases of an outbreak. It permits even non-specialist users to input data most conveniently and track outbreaks in real-time. We applied our tool to visualize the SARS 2003, MERS, and COVID19 epidemics, and provided them as examples on the website. Through the zoom feature, it is also possible to visualize cases at city and even neighborhood levels. We made the tool freely available at https://outbreak.sysbio.tools/. OUTBREAK has the potential to guide and help health authorities to intervene and minimize the effects of outbreaks.

Resumo: A Supply Chain vem passando por grandes transformações em função da necessidade de implementação de novas tecnologias da Indústria 4.0, como a Internet das Coisas, Big Data, Sistemas Físico-Cibernéticos e a Computação em Nuvem. Graças a essas tecnologias, bem como a seus subsistemas e componentes, a integração total da Supply Chain está se tornando possível. No entanto, observa-se que ainda não estão totalmente claros e identificados os reais impactos, positivos ou negativos, que as tecnologias da Indústria 4.0 causam na Supply Chain. Este trabalho tem como objetivo identificar e apresentar uma análise dos desafios que as empresas deverão enfrentar ao implantar as tecnologias da Indústria 4.0 na Supply Chain. Para isso, foram selecionados e analisados, por meio de uma revisão sistemática da literatura, os trabalhos mais relevantes sobre o tema. A revisão identificou vinte desafios agrupados em quatro macrogrupos: (1) desafios técnicos, (2) desafios financeiros, ambientais e legais, (3) desafios tecnológicos e (4) desafios socioculturais. Observa-se que estes desafios requerem grande atenção e estudos mais aprofundados por parte da academia para apoiar a indústria no sentido de mitigá-los e, assim, permitir melhor aproveitamento dos recursos tecnológicos disponíveis e otimizar o desempenho das operações da Supply Chain.

Abstract: The Supply Chain has undergone major transformations due to the need to implement new Industry 4.0 technologies, such as Internet of Things, Big Data, Cyber-Physical Systems and Cloud Computing. Thanks to these technologies, as well as to their subsystems and components, full integration of the supply chain is becoming possible. However, it is observed that the real impacts of Industry 4.0 technologies, rather positive or negative, are not yet totally clear and identified. This paper aims to identify and present an analysis of the challenges and obstacles that Industry 4.0 technologies may cause in the Supply Chain. For this, the most relevant papers on the topic were selected and analyzed through a systematic literature review. Twenty challenges grouped into four macrogroups were identified: (1) technical challenges, (2) financial, environmental and legal challenges, (3) technological challenges, and (4) sociocultural challenges. It should be noted that these challenges require greater attention and more in-depth studies on the part of the academy to support industry in order to mitigate them and thus allow better use of the available technological resources and optimize the performance of Supply Chain operations.

Four new complexes of formula [Fe(H2pcpa)2(H2O)2] (1), {[Mn(Hpcpa)(H2O)3]•1/2H2O}n (2), {[Zn(Hpcpa)(H2O)3]•1/2H2O}n (3) and [Cu2(Hpcpa)2(bipy)2]•8H2O (4) [H3pcpa = N-(4-carboxyphenyl)oxamic acid; bipy = 2,2¢-bipyridine] have been synthesized and their structures determined by X-ray diffraction. The structure of 1 consists of mononuclear iron(II) units where each iron(II) ion is six-coordinate by two trans-positioned water molecules and two bidentate H2pcpa- ligands building a distorted octahedral environment. 2 and 3 consist of neutral zigzag chains of MnII and ZnII ions respectively, the Hpcpa2- groups acting as linkers in a bidentate/monodentate coordination mode with three mer-positioned water molecules achieving the six-coordination around the metal centers. Compound 4 is a neutral centrosymmetric dicopper(II) complex where two Hpcpa2- groups adopting the bidentate/monodentate coordination mode and act as bridges and bidentate bipy molecules act as end-cap ligands, describing a square pyramidal surrounding around each copper atom. Cryomagnetic measurements for 1, 2 and 4 in the temperature range 1.9-300 K reveal the occurrence of a field-induced single-ion magnet (SIM) behavior (1) and weak interchain (J = -0.22 cm-1, 2) and intradimer (J = -0.39 cm-1, 4) antiferromagnetic interactions, the Hamiltonian being defined as H = -J Sa.Sb.

Resumen Este artículo presenta un sistema de adquisición de datos para medir la fuerza de corte en el proceso de roscado hecho en un torno convencional. São usados modelos analíticos para encontrar la profundidad del corte de la herramienta de fabricación. La fuerza de la herramienta de corte puede ser responsable por el colapso de la herramienta debido a la deformación plástica de la arista. La fuerza de corte fue obtenida a través de medidas directas en muestras seleccionadas permitiendo obtener datos confiables comparados con datos obtenidos del análisis teórico. El sistema fue implementado en LabView® analizando diversas variables que entran en juego en el proceso de manufactura en tornos convencionales. Es posible así encontrar en tiempo real la profundidad del corte. Específicamente, los autores presentan resultados usando los modelos de Fredericks, Sandvik y Lira. El análisis permite obtener conclusiones sobre la fuerza de corte de cada modelo.

Abstract This report concerns a data acquisition system with the final idea of measuring the cutting force in the threading process done on a conventional lathe. Analytical models are used to find the depth of cut of the machining tool. This is important because the machining force can be responsible for the tool collapse by plastic edge deformation. The cutting force was obtained through direct measurements in selected samples. This allows obtaining more realistic data compared with data obtained by analytical estimation from theory. The data acquisition system was implemented in LabView®, and it allowed analyzing the several variables involved in the machining process on conventional lathes. In such a way, it is possible to find out, in real time, the depth of cut variable. Specifically, the authors present results obtained from analysis of Fredericks, Sandvik and Lira models. This analysis allows drawing conclusions about the cutting force from each model.

RESUMO Quantificar o tamanho de materiais em escala nanométrica é um dos desafios a serem superados, uma vez que existem técnicas diferentes. A equação de Scherrer modificada foi usada para estimar o tamanho das partículas de dióxido de titânio em escala nanométrica. Dióxido de titânio com tamanho nominal de nanopartícula de 21 nm foi usado como padrão para determinar a precisão da equação modificada. A partir dos dados de raios-X, para a amostra sem tratamento térmico foi obtido um valor médio do tamanho das nanopartículas de 20,63 nm. Um tratamento estatístico foi usado para fazer uma correlação entre o valor estimando pela equação de Scherrer modificada e o valor nominal de 21nm. Um desvio de 0,70 foi encontrado entre o valor calculado e o valor nominal, indicando uma concordância entre os valores. Adicionalmente, a influência da temperatura sobre o tamanho médio das nanopartículas de dióxido de titânio foi pesquisada.

ABSTRACT The materials sizing in nano-scale is a challenge to be overcome, because the size determined by various methods differ. In order to shed light about the nanomaterials sizing, a modified Scherrer's equation was applied to estimate more accurately the nanostructured titanium dioxide crystal size. The manufactured titanium dioxide-nanostructured powder with nominal average size about 21nm was used as the reference standard to determine the accurate of modified equation. From X-ray diffraction data, an average crystal size about 20.63 nm was achieved for unheated sample. To establish a relation between the result obtained with modified Scherrer's equation and the nominal average crystal size, a statistical treatment and a comparative assessment were performed. The average absolute divergence does not exceed 0.70 nm. The value of crystal size determined from X-ray data was in good agreement with that informed by the supplier. Additionally, the behavior of sample was studied as a function of temperature.

Resumo O objetivo do artigo é avaliar os fatores que influenciam a escolha do tipo de curso superior no Brasil. A partir dos dados dos Censos Demográficos de 2000 e 2010 e da Sinopse de Educação Superior de 2000, modelamos a escolha do curso por parte do indivíduo usando o modelo logit condicional. As variáveis que condicionam esta escolha são: características individuais e familiares; relação candidato-vaga; tempo de duração do curso; e incentivos econômicos das carreiras (média e variabilidade do rendimento e desemprego). Esta análise é feita para o total de indivíduos que estavam em idade de prestar vestibular no ano de 2000. Os resultados indicam que os rendimentos e a taxa de desemprego influenciam apenas os indivíduos do quartil mais elevado, enquanto a concorrência possui maior impacto sobre a escolha dos indivíduos do quartil inferior de distribuição.

Abstract The aim of this paper is to evaluate the factors conditioning the choice of type of higher education course in Brazil. Based on data from the 2000 and 2010 Demographic Censuses and the Higher Education Synopsis from2000, we model the choice of course by the individual using the conditional logit model. The variables that affect this choice are: individual and family characteristics; candidate-vacancy relationship (competition) and course duration; income (mean and variability) and unemployment. This analysis is done for the total number of individuals with the age required for college entrance examination in the year 2000. The results indicated that expected yields, unemployment rate and the wage variability of careers only influence the individuals of the highest quartile. On the other hand, competition in the selective process has a greater impact on the choice of individuals in the lower distribution quartile.

Resumen El objetivo del artículo es evaluar los factores que influyen en la elección del tipo de curso superior en Brasil. A partir de los datos de los censos demográficos de 2000 y 2010 y de la Sinopsis de Educación Superior de 2000, modelamos la elección del curso por parte del individuo usando el modelo logit condicional. Las variables que condicionan esta elección son: características individuales y familiares; relación candidato-vacante y el tiempo de duración del curso e incentivos económicos de las carreras (media y variabilidad del rendimiento y desempleo). Este análisis fue hecho para el total de individuos en edad de presentarse al vestibular en el año 2000. Los resultados indicaron que los ingresos y la tasa de desempleo influyen solo en los indivíduos del cuartil más elevado. La competencia tiene mayor impacto en la elección de los individuos del cuartil inferior de distribución.

Xanthenones were synthesized via one-pot tricomponent reaction, under solvent-free conditions, using aldehydes, phenolic and cyclic 1,3-dicarbonyl compounds. Natural organic acids (NOAs), compounds present in many living metabolisms, were used as potential green catalysts. NOA are considered to be more eco-friendly and user-friendly alternative to traditional methodologies. Optimization studies showed that oxalic acid was the best NOA catalyst for such reaction furnishing the xanthenones with up to 93% of yield. Theoretical calculations were performed to evaluate this reaction mechanism and regioselectivity. The results showed that the regiospecificity of this three-component reaction is kinetically and thermodynamically controlled by the addition of β-naphthol C2, instead of C10, to the aldehyde. Our results also disclosed two xanthenones as novel calcium channels blockers. Eco-friendly reaction conditions, easy workup procedure, short reaction times and good yields are some of the advantages of our methodology.

4'-Hydroxychalcones have been reported to possess several beneficial biological effects. Several lines of evidence accumulated to demonstrate increased biological activities of the Mannich base derivatives of the parent 4'-hydroxychalcones. Bioactivities of chalcones and related α,β-unsaturated ketones are frequently associated with their reactivity with cellular thiols, such as GSH. For comparison of GSH reactivity, two bis Mannich bases of two 4'-hydroxychalcones were synthesized and reacted with GSH under non-cellular conditions. Reversed-phase thin layer chromatography (RP-TLC) and reversed-phase high performance liquid chromatography (RP-HPLC) analysis showed formation of two polar products which structures were confirmed by RP-HPLC-ESI-MS (RP-HPLC-electrospray ionization mass spectrometry) as 1:1 chalcone-GSH adducts in each case. At pH values below 8.0, the two bis Mannich bases showed higher GSH reactivity than two 4'-hydroxychalcones. Influence of the nature of the amino groups, the ring-B substituents and pH of the medium on reactivity was also investigated. The findings could serve as useful structure-activity information for subsequent molecular modification of thiol-reactive 4'-hydroxychalcones.