Resumen Introducción: existen múltiples variantes del ensayo clínico aleatorizado; según diseño: grupos paralelos, cruzado, factorial, asignación por grupos, N de 1, pareado, retiro, adaptativo y pragmático; y por propósito: superioridad, no inferioridad y equivalencia. Debido a esta heterogeneidad, en 1996 se introdujo el CONSORT (Consolidated Standards of Reporting Trials) para suministrar una guía para el reporte de los ensayos clínicos aleatorizados. Objetivo: describir la tendencia de publicación de los tipos de ensayos clínicos aleatorizados durante 40 años, en relación con la publicación del CONSORT y sus extensiones. Métodos: se utilizó la herramienta PubMed para realizar una búsqueda de ensayos clínicos aleatorizados publicados entre 1979 y 2018, discriminándolos según las variantes descritas. Resultados: se encontraron 472 114 artículos publicados, el 90.2% no reportó tipo de diseño y 98.2% no reportó propósito. Entre los artículos que reportaron la variante de ensayos clínicos aleatorizados, el diseño predominante fue el cruzado (5.9%), seguido por grupos paralelos (2.34%); mientras que el propósito más frecuente fue el de superioridad (0.84%). Hubo un aumento en la proporción de artículos por variante publicados después del lanzamiento del CONSORT para los diseños de: grupos paralelos; diferencia de proporciones 1.89 IC 95% (1.1-2.7); pareado 1.07 IC 95% (0.2-1.9); pragmático 4.73 IC 95% (4.4-5.1); y para el propósito de no inferioridad 5.97 IC 95% (5.6-6.3). Discusión: la mayoría de los artículos sobre ensayos clínicos aleatorizados no mencionan en su título y resumen la variante de estos. La proporción de artículos que sí lo hicieron, aumentó discre tamente después de la publicación del CONSORT. (Acta Med Colomb 2021; 46. DOI:https://doi.org/10.36104/amc.2021.1884).

Abstract Introduction: there are several variations of randomized clinical trials. Trials can be classi fied by design as parallel, cross-over, factorial, assignment by group, n-of-1, paired, withdrawal, adaptive and pragmatic; and by purpose as superiority, non-inferiority and equivalence. Given this heterogeneity, the Consolidated Standards of Reporting Trials (CONSORT) were introduced in 1996 to provide a guideline for reporting randomized clinical trials. Objective: to describe the publication tendency of the various types of randomized clinical trials over 40 years, with reference to the publication of CONSORT and its extensions. Methods: the PubMed tool was used to search for randomized clinical trials published between 1979 and 2018, classifying them according to the varieties described. Results: a total of 472,114 published articles were found; 90.2% did not report the type of design and 98.2% did not report the purpose. Among the articles that reported the variety of randomized clinical trial, the predominant design was cross-over (5.9%), followed by parallel groups (2.34%); while the most common purpose was superiority (0.84%). After the launch of CONSORT, there was an increased proportion of articles published with the following designs: parallel groups; difference in proportions 1.89 95% CI (1.1-2.7); paired 1.07 95% CI (0.2-1.9); and pragmatic 4.73 95% CI (4.4-5.1); and for the purpose of non-inferiority 5.97 95% CI (5.6-6.3). Discussion: most articles on randomized clinical trials do not mention their type in the title and abstract. The proportion of articles that did, increased slightly after CONSORT was published. (Acta Med Colomb 2021; 46. DOI:https://doi.org/10.36104/amc.2021.1884).

Resumen Introducción: Se hace una correlación entre la osteoatrosis y las condiciones laborales, hábitos y estilos de vida de los trabajadores informales del centro de Medellín, Colombia. Objetivo: Identificar la relación de la osteoartritis y la prevalencia de enfermedades crónicas y degenerativas con las condiciones sociodemográficas, laborales, hábitos y estilos de vida en un grupo de trabajadores informales de Medellín, Colombia. Materiales y métodos: Estudio transversal, con fuente primaria de información de 686 trabajadores informales. Se realizó una encuesta asistida, previa toma de consentimiento. Se seleccionaron 289 trabajadores con diagnóstico de enfermedad crónica o degenerativa, ≥18 años, con ≥5 años en su oficio. Se realizaron análisis exploratorios y de asociación con prueba Chi2, y cálculo de RP con IC del 95%. Resultados: el 79,9% de la población padecía alguna enfermedad crónica. El 3,46% presentaba diagnóstico de osteoartritis, siendo significativamente mayor (p<0,05) en quienes tenían entre 21 y 30 años en su oficio (RP=5,62. IC:1,20;26,34). También fue mayor la prevalencia de osteoartritis en; >45 años (RP=2,26), mujeres (RP:4,44), trabajadores sedentarios (RP=1,71), obesos (RP=3,40), así como en quienes habían sido obreros (RP=1,30), en aquellos que tenían puestos de venta semiestacionaria (RP=2,21), vendían productos de cosecha y perecederos (RP=1,78), en quienes trabajaban >8 horas diarias (RP:2,77), ≤5días a la semana (RP=3,10), no tenían espacio suficiente para moverse (RP=2,08), y en quienes tenían posturas o movimientos forzados (RP=2,72). Conclusión: En la población de vendedores informales del centro de Medellín, los factores sociodemográficos, laborales, hábitos y estilos de vida modificables se relacionan con una mayor prevalencia de osteoartritis.

Abstract Introduction: Se hace una correlación entre la osteoatrosis y las condiciones laborales, hábitos y estilos de vida de los trabajadores informales del centro de Medellín, Colombia. A correlation is made regarding osteoarthrosis and working conditions and lifestyles of informal workers in Medellin downtown. Objective: To identify the prevalence of chronic and degenerative diseases, and the relationship of osteoarthritis with sociodemographic and work conditions, habits and lifestyles, in a group of informal workers from Medellín, Colombia. Materials and methods: Cross-sectional study, with a primary source of information, with 686 workers. An assisted survey was applied, after obtaining consent. 289 workers with a diagnosis of chronic or degenerative disease, ≥18 years old, with ≥5 years in their profession were included. Exploratory and association analysis with Chi2 test, and calculation of PR with 95% CI. Results: 79.9% of them suffered from a chronic disease. 3.46% had a diagnosis of osteoarthrosis, being significantly higher (p <0.05) in those who had spent between 21 and 30 years performing their profession (PR=5,62.CI:1,20;26,34). The prevalence of osteoarthrosis was also higher in; >45 years (PR=2.26), women (PR=4,44), sedentary workers (PR=1,71), obese (PR=3,40), as well as those who had been brick-layers (PR=1,30), in those who had semi-stationary sales positions (PR=2,21), they sold harvest and perishable products (PR=1,78), in those who worked> 8 hours a day (PR:2,77), ≤ 5 days a week (PR=3,10), they did not have enough space to move (PR = 2.08), and in those who had forced postures or movements (PR=2,72). Conclusion: sociodemographic and work factors, habits and modifiable lifestyles are related to a higher prevalence of osteoarthrosis in this working population.

Abstract Introduction: the production of biogas is a sustainable alternative for the energy use of organic waste. This investigation presents the study and modeling of biogas production, generated by the co-digestion of livestock excreta and cheese whey. Method: Anaerobic Digestion (DA) experiments were carried out, using hermetic reactors, at room temperature monitored for 75 consecutive days based on the biochemical methane potential (BMP) method. The logistic models were used: exponential maximum growth, Gompertz and Richards modified to represent the kinetics of the methane production phenomenon. Results and discussions: the maximum methane production rate, the duration of the lag phase, and the accumulated methane production potential were determined. The residual sum of squares and the correlation coefficient were compared to identify the mathematical model that best describes the phenomenon. It was found that there is a potential for the generation of biogas and the use of the residues experienced in this work in co-digestion. Conclusions: experimentation and mathematical modeling allowed to describe the phenomenon of biogas production, with residues from the dairy industry and livestock systems. The results of the research show the potential to incentivize energy production in the regional agricultural sector, based on DA technology, taking advantage of the dairy industry waste under the concept of circular economy.

Resumen Introducción: la producción de biogás es una alternativa sostenible para el aprovechamiento energético de los residuos orgánicos. Esta investigación presenta el estudio y modelación de la producción de biogás, generada por la codigestión de excreta de vaca y suero de leche. Método: se realizaron experimentos de Digestión Anaerobia (DA), utilizando reactores herméticos, a temperatura ambiente monitoreados por 75 días consecutivos con base en el método de potencial bioquímico de metano (BMP). Se utilizaron los modelos logísticos: exponencial de crecimiento máximo Gompertz y Richards modificados para representar la cinética del fenómeno de producción de metano. Resultados y discusiones: se determinó la tasa máxima de producción de metano, la duración de la fase lag, y el potencial de producción de metano acumulado. Se comparó la suma de cuadrados residual y el coeficiente de correlación para identificar el modelo matemático que mejor describe el fenómeno. Se encontró que existe un potencial para la generación de biogás y el aprovechamiento de los residuos experimentados en codigestión. Conclusiones: la experimentación y modelación matemática permitió describir el fenómeno de la producción de biogás, con residuos de la industria láctea y de los sistemas pecuarios. Los resultados de la investigación presentan el potencial de incentivar la producción de energía, en el sector agropecuario regional, a partir de la tecnología DA aprovechando los residuos de la industria láctea bajo el concepto de economía circular.

Resumen Introducción. Las tasas de homicidio, suicidio y agresión son mayores en el sexo masculino; la testosterona podría desempeñar un papel importante en el desarrollo de estos comportamientos. Objetivo. Realizar una revisión de los aspectos endocrinos y neurobiológicos de la testosterona y su relación con comportamientos agresivos, homicidas y suicidas. Materiales y métodos. Se realizó una revisión narrativa con diferentes estrategias de búsqueda en PubMed, SpringerLink, ScienceDirect y SciELO. Se incluyeron artículos de investigación, revisiones y reportes de caso publicados en español y en inglés entre 2002 y 2018. Resultados. De los 66 estudios incluidos en la revisión, más del 50% asociaron el comportamiento agresivo u homicida con niveles elevados de testosterona, hormona que podría modular la actividad de las vías cerebrales serotoninérgicas y dopaminérgicas involucradas en el comportamiento agresivo por medio de receptores androgénicos y estrogénicos. Se encontraron relaciones entre uso de esteroides anabólicos y homicidio, y entre testosterona circulante en mujeres y rasgos de personalidad antisocial. Asimismo, se observaron cambios de concentraciones séricas de testosterona en sujetos con tendencias suicidas. Conclusión. La información encontrada en la revisión sugiere que sí existe una asociación entre los niveles de testosterona y el desarrollo de comportamientos agresivos, homicidas y suicidas.

Abstract Introduction: Homicide, suicide, and assault rates are higher in males. Testosterone may play an important role in the development of these behaviors. Objective: To review the endocrine and neurobiological aspects of testosterone and its relationship with aggressive, homicidal and suicidal behaviors. Materials and methods: A literature review was conducted using different search strategies in the PubMed, SpringerLink, ScienceDirect and SciELO databases. Research articles, reviews and case reports published in Spanish and English between 2002 and 2018 were included. Results: Out of the 66 studies included in the review, over 50% reported an association between aggressive or homicidal behavior with high levels of testosterone, a hormone that may modulate the activity of serotonergic and dopaminergic brain pathways involved in aggressive behavior via androgen and estrogen receptors. Associations between anabolic steroid use and homicide, and between circulating testosterone in women and antisocial personality traits were found. Changes in serum testosterone concentrations were also observed in individuals with suicidal tendencies. Conclusion: The information found in this review suggests that there is indeed an association between testosterone levels and the development of aggressive, homicidal and suicidal behaviors.

Abstract: This study aimed to determine the wood density using destructive and non-destructive sampling methods in a eucalypt hybrid clonal and determine the best point for the non-destructive sampling of the tree. A 5,6-year-oldEucalyptus urophylla x Eucalyptus grandis hybrid clone, from an energetic forest, was used, planted in the municipal district of Martinho Campos, MG, Brazil. The trees were sampled by three methods of destructive sampling. The traditional method (0%, 25%, 50%,75% and 100% of the commercial height Hc); alternative method (2%, 10%, 30% and 70% Hc) and via a meter by meter method starting from a height of 1,30 m from the soil (DBH). Three non-destructive sampling methods were also appraised: Resistograph®, Pilodyn® and 22 mm diameter cores at a DBH. The use of the Resistograph® at the 1,10 m or 1,50 m points and the Pilodyn® at 1,50m of height from the soil results the best correlations with the basic density determined by the three destructive sampling methods considered.

Resumo As alterações na qualidade da madeira das árvores de Eucalyptus causadas pela fertilização e disponibilidade hídrica podem influenciar as características da biomassa e do carvão vegetal. O objetivo deste trabalho foi avaliar as características da madeira e do carvão vegetal de Eucalyptus grandis sob o efeito da fertilização com potássio e sódio (controle; 4,5 kmol ha-1 de KCl e 4,5 kmol ha-1 de NaCl) e disponibilidade hídrica (100% e 63% das chuvas, com exclusão artificial por lonas em polietileno). Árvores de Eucalyptus de cada tratamento de fertilização x disponibilidade hídrica, com cinco anos de idade, foram cortadas e obtidas amostras, na altura do DAP para a caracterização energética e física da biomassa e do carvão vegetal. A aplicação da fertilização com K e Na não influenciou as características energéticas e físicas da biomassa e do carvão vegetal. A exclusão parcial da água da chuva na plantação florestal de Eucalyptus grandis promoveu alterações nas características da biomassa e do carvão vegetal, com redução do teor de cinzas, aumento da densidade da madeira e do carvão vegetal e rendimento gravimétrico do carvão vegetal.

Abstract Changes in the wood quality of Eucalyptus trees caused by fertilization and water availability may influence the characteristics of biomass and charcoal. The aim of this study was to evaluate the effects of potassium and sodium fertilization (control; 4.5 kmol ha-1 of KCl and 4.5 kmol ha-1 of NaCl) and water availability (100% and 63% rainfall with artificial exclusion) on the energetic and physical characteristics of biomass and charcoal. Eucalyptus trees of each fertilization x water availability treatments, at five years old, were cut down and the samples were taken at the DBH for the energetic and physical characterization of biomass and charcoal. The application of fertilization with K and Na did not influence the energetic and physical characteristics of biomass and charcoal. The partial exclusion of rainwater in the Eucalyptus grandis forest plantation promoted changes in the characteristics of biomass and charcoal, with reduction of ash content, and increase of wood and charcoal density and the charcoal gravimetric yield.

RESUMO: A escolarização dos Adolescentes em Conflitos com a Lei caracteriza-se, em geral, por indicadores negativos. Focalizando a experiência escolar destes adolescentes, Bazon, Silva e Ferrari relatam a existência de dois padrões de trajetórias, tendo por base dados de uma amostra de 06 jovens. Adotando este estudo como referência, a presente pesquisa teve como objetivos descrever o percurso escolar de adolescentes em conflito com a Lei e compreender sua experiência escolar. A investigação, de natureza qualitativa, baseada em uma abordagem biográfica, contou com a colaboração de 12 adolescentes. Os dados coletados através de entrevistas foram tratados por meio de análise de conteúdo temática. Os resultados indicaram duas trajetórias escolares: Trajetória I - Da boa à má experiência escolar e Trajetória II - Uma experiência escolar preponderantemente negativa, embora pontuada por vivências positivas. As trajetórias escolares encontradas assemelharam-se às descritas por Bazon, Silva e Ferrari, porém acrescentam/detalham informações.

ABSTRACT: The school life of Adolescents in Conflict with the Law is characterized by negative indicators. In this regard, Bazon, Silva and Ferrari report a study in which two trajectory patterns related to the schooling experience of juvenile offenders were identified and described. Based on this study, the present study aimed to describe the school experience of Adolescents in Conflict with the Law and understand their school experience. The research, of a qualitative nature, based on a biographical approach, had the collaboration of 12 adolescents. The data collected through interviews were treated through thematic content analysis. The results indicated two school trajectories: Trajectory I - From good to bad school experience and trajectory II - A predominantly negative school experience, although punctuated by positive experiences. The school trajectories found resemble those described by Bazon, Silva and Ferrari, but they add / detail information.

Sweet's syndrome was described in 1964 by Robert Douglas Sweet, as an entity he named acute febrile neutrophilic dermatosis. It is characterized by five main features: 1) sudden appearance of erythematous and tender plaques on the face, neck and extremities; 2) fever; 3) polymorphonuclear leukocytes; 4) predominantly neutrophilic dense infiltrate in the dermis, and 5) rapid response to steroid therapy. Sweet's syndrome can be classified into five groups: idiopathic, parainflammatory, paraneoplastic, drug-induced, and pregnancy-related. Twenty percent of cases are associated with malignancies; 85% out of them involve hematologic alignancies and the remaining 15%, solid tumors. A series of seven cases of Sweet's syndrome associated with neoplasms which were diagnosed from 2002 to 2006 is presented. Six cases were related to oncohematologic diseases and one to solid tumors. These results highlight the importance of the diagnosis of the syndrome, since it may predict tumor relapse or underlying disease progression. The timely use of diagnostic and treatment methods may improve the quality of life of these patients. The fact that oncology patients take multiple medications (a colony-stimulating factor) which may be associated with the onset of this entity must also be considered in excluding possible causes.

El síndrome de Sweet fue descrito en el año 1964 por Robert Douglas Sweet, como una entidad a la cual denominó dermatosis neutrofílica febril y aguda. Se caracteriza por cinco rasgos principales: 1) aparición brusca de placas eritemato-dolorosas en cara, cuello y extremidades; 2) fiebre; 3) leucocitosis polimorfonuclear; 4) denso infiltrado dérmico a predominio neutrofilico; 5) rápida respuesta al tratamiento esteroideo. Se puede clasificar en cinco grupos: idiopático, parainflamatorio, paraneoplásico, secundario a drogas y asociado a embarazo. En el 20% de los casos se asocia a enfermedades malignas, representando las hematológicas el 85% y los tumores sólidos el 15% restante. Se presenta una serie de siete casos de síndrome de Sweet asociado a neoplasias, diagnosticados durante el período 2002-2006, de los cuales seis correspondieron a enfermedades oncohematológicas y el restante a tumores sólidos. Como comentario de dicha casuística, se hace hincapié en la importancia del diagnóstico de este síndrome, debido a que puede anunciar la recaída del tumor o la progresión de la enfermedad de base. De esta manera, mediante el uso de métodos de diagnóstico y tratamiento oportunos, se lograría mejorar la calida de vida de estos pacientes. También debe tenerse en cuenta, que los pacientes oncológicos reciben múltiples medicaciones (factor estimulante de colonias), que pueden estar implicadas en la aparición de esta entidad, debiendo ser las mismas descartadas como posibles causas.