Abstract Aquafaba, a liquid from the cooking of chickpeas, has technological properties that have been increasingly used in the food sector, such as emulsifying, foaming, and gelling properties. Its application occurs mainly in mayonnaise and meringues, replacing the egg. This study aims to carry out the technological prospection of aquafaba through the study of patents in national and international databases, seeking to assess current and future market demand, and thus gather relevant information that allows attracting the interest of the food industry to the use of this new functional and sustainable food. Few related patents are reported, and they are concentrated in a few countries, indicating a promising way of exploring this product. Aquafaba chickpeas sector emulsifying foaming meringues egg databases demand reported countries product

ABSTRACT The objective of the study was to identify the resistance of Mycobacterium tuberculosis to drugs in Paraguay, 2014 to 2017. A retrospective observational study was carried out. The data from the National Tuberculosis Program of Paraguay between the years 2014 to 2017 were used. All patients with a diagnosis of Tuberculosis who underwent a resistance test were included. Data were extracted in Excel and analyzed with Stata 17.0. 3429 tuberculosis patients who had a result of at least one sensitivity test were included. Resistance was found in 2.1% of patients. Resistance to Rifampicin was present in 0.3% of cases while to Izionazide in 0.6% of cases. The prevalence of resistance was higher in men 3.4 (95% CI 2.2 - 4.8) p = 0.003, who resided in the Chaco 6.0 (95% CI 3.4 - 9.7) p = 0.000, previously treated 2.7 (95% CI 1.1 - 5.1) p = 0.010. In the model, it was observed that a previously treated patient has a greater chance of having resistance OR 2.62 (95% CI 1.1 - 6.24). The prevalence of resistance of Mycobacterium tuberculosis to drugs was related to having been previously treated.

RESUMEN El objetivo del estudio fue identificar la resistencia del Mycobacterium tuberculosis a los fármacos en Paraguay, 2014 a 2017. Se realizó un estudio observacional retrospectivo. Se utilizaron los datos del Programa Nacional de Tuberculosis del Paraguay comprendidos entre los años 2014 a 2017. Se incluyeron todos los pacientes con diagnóstico de Tuberculosis que se realizaron un test de resistencia. Se extrajeron los datos en Excel y fueron analizados con Stata 17.0. Se incluyeron 3429 pacientes con tuberculosis que contaban con resultado de al menos una prueba de sensibilidad. La resistencia se encontró en 2.1% de los pacientes. La resistencia a la Rifampicina estuvo presente en el 0.3% de los casos mientras que a la Izionazida en el 0.6% de los casos. La prevalencia de resistencia fue más alta en hombres 3.4 (IC 95% 2.2 - 4.8) p=0.003, que residían en el chaco 6.0 (IC 95% 3.4 - 9.7) p=0.000, previamente tratados 2.7 (IC 95% 1.1 - 5.1) p=0.010. En el modelo se pudo observar que un paciente previamente tratado tiene mayores posibilidades de tener resistencia OR 2.62 (IC 95% 1.1 - 6.24). La prevalencia de resistencia del Mycobacterium tuberculosis a fármacos estuvo relacionada con haber sido previamente tratado.

For billions of years, the phenomena of life and biocatalysis have been intertwined. If in the beginning biocatalysis was fundamental for the origin of life, currently it is very important for the cleaner production of pharmaceuticals and fine chemical intermediates. There is no doubt that drugs have brought great benefits to humanity, but currently, the expectations of modern society are focused on drugs with greater safety, less environmental impact, more sustainable practices, and less energy use. This review intends to show how the challenges for the production of some low molecular weight drugs produced by synthetic routes that involve at least one biotechnological step using microorganisms or enzymes were faced. These biotechnological drug production routes are more sustainable than conventional synthetic routes, as they produce a much smaller amount of waste, use moderate reaction conditions, have lower energy consumption, and have lower metal consumption, in addition to being more selective. Additionally, many natural products have structures too complex to be produced exclusively by chemical routes. The large-scale and economical production of these drugs is of great importance for fighting cancer as well as inflammatory, infectious, autoimmune, metabolic, hormonal, cardiovascular, and neurological diseases, among others.

Abstract Introduction The evolving COVID-19 pandemic became a hallmark in human history, not only by changing lifestyles, but also by enriching scientific knowledge on viral infection and its consequences. Objective Although the management of cardiorespiratory changes is pivotal to a favorable prognosis during severe clinical findings, dysregulation of other systems caused by SARS-CoV-2 infection may imbalance erythrocyte dynamics, such as a bidirectional positive feedback loop pathophysiology. Method and Results Recent evidence shows that SARS-CoV-2 is capable of affecting the genetics and dynamics of erythrocytes and this coexists with a non-homeostatic function of cardiovascular, respiratory and renal systems during COVID-19. In hypothesis, SARS-CoV-2-induced systematical alterations of erythrocytes dynamics would constitute a setpoint for COVID-19-related multiple organ failure syndrome and death. Conclusion The present review covers the most frequent erythrocyte-related non-homeostatic findings during COVID-19 capable of providing mechanistic clues of SARS-CoV-2-induced infection and inspiring therapeutic-oriented scientific evidence.

RESUMO Objetivo: Compreender como pessoas com lúpus experienciaram o diagnóstico e como lidam com as complicações advindas da doença. Método: Estudo qualitativo, cujos dados foram coletados entre fevereiro e julho de 2019, mediante entrevistas semiestruturadas com 26 indivíduos e submetidos à análise de conteúdo. Resultados: Emergiram três categorias que mostram o adoecimento por lúpus como uma experiência difícil, permeada por tristeza, medo e sofrimento, que além de estar atrelado ao desconhecimento da sociedade sobre a doença, impacta negativamente na vida de quem o vivencia. Para além disso, evidenciam que o tempo de convivência com a doença favorece o desenvolvimento de estratégias de autocuidado e maior adesão terapêutica e, por consequência, maiores períodos de remissão da doença. Considerações: Imprescindível mais divulgação sobre a doença e suas implicações no cotidiano dos acometidos, culminando em maior compreensão de familiares, amigos e colegas e melhorias na atenção à saúde e qualidade de vida destas pessoas.

ABSTRACT Objective: To understand how people with lupus experience the diagnosis and how they deal with complications arising from the disease. Method: Qualitative study, whose data were collected between February and July 2019, through semi-structured interviews with 26 individuals and submitted to content analysis. Results: Three categories emerged that show illness from lupus as a difficult experience, permeated by sadness, fear and suffering, which, in addition to being linked to society’s lack of knowledge about the disease, negatively impacts the lives of those who experience it. Furthermore, they show that the time of living with the disease favors the development of self-care strategies and greater therapeutic adherence and, consequently, longer periods of disease remission. Considerations: More disclosure about the disease and its implications in the daily lives of those affected is essential, culminating in greater understanding of family, friends and colleagues and improvements in health care and quality of life for these people.

RESUMEN Objetivo: Comprender cómo las personas con lupus experimentan el diagnóstico y cómo afrontan las complicaciones derivadas de la enfermedad. Método: Estudio cualitativo, cuyos datos fueron recolectados entre febrero y julio de 2019, mediante entrevistas semiestructuradas con 26 individuos y sometidos a análisis de contenido. Resultados: Surgieron tres categorías que muestran la enfermedad por lupus como una experiencia difícil, impregnada de tristeza, miedo y sufrimiento, que además de estar vinculada al desconocimiento de la sociedad sobre la enfermedad, impacta negativamente en la vida de quienes la padecen. Además, muestran que el tiempo de convivencia con la enfermedad favorece el desarrollo de estrategias de autocuidado y una mayor adherencia terapéutica y, en consecuencia, mayores periodos de remisión de la enfermedad. Consideraciones: Es esencial una mayor divulgación sobre la enfermedad y sus implicaciones en la vida diaria de los afectados, que culmine en una mayor comprensión de la familia, amigos y colegas y mejoras en la atención médica y la calidad de vida de estas personas.

RESUMO Objetivo: avaliar o risco cardiovascular entre trabalhadores de enfermagem de um hospital público. Método: estudo seccional, com 324 trabalhadores de enfermagem, utilizando-se questionário composto por dois blocos de informações. O primeiro abrangeu questões relacionadas às características sociodemográficas e laborais, de saúde, e o segundo, o Escore de Risco de Framingham Revisado (ERF), para estratificar o risco cardiovascular. Para avaliar o estresse psicossocial no trabalho, utilizou-se a Escala Sueca de Demanda Controle Social. Resultados: o fator de risco modificável para DCVs mais prevalente foi a circunferência de cintura (75,9%), seguida de sobrepeso (43,8%), obesidade (29,3%), etilismo (21,9%), colesterol da lipoproteína de densidade baixa (LDL) > 130 (20,7%) e Hipertensão Arterial Sistêmica (20,4%). Conclusão: verificou-se que 96% dos trabalhadores apresentaram baixo risco para desenvolverem doenças cardiovasculares nos próximos dez anos, e trabalhadores homens com idade >40 anos jornada de trabalho menor apresentam maiores chances de apresentar doença cardiovascular.

ABSTRACT Objective: to assess cardiovascular risk among nursing workers at a public hospital. Method: a cross-sectional study, with 324 nursing workers, using a questionnaire composed of two information blocks. The first covered issues related to sociodemographic and occupational and health characteristics, and the second, the Revised Framingham Risk Score (FRS), to stratify cardiovascular risk. To assess work-related psychosocial stress, the Swedish Social Control Demand Scale was used. Results: the most prevalent modifiable risk factor for CVDs was waist circumference (75.9%), followed by overweight (43.8%), obesity (29.3%), alcohol consumption (21.9%), lipoprotein cholesterol low density (LDL) > 130 (20.7%) and hypertension (20.4%) Conclusion: it was found that 96% of workers had a low risk of developing cardiovascular disease in the next ten years, and male workers aged >40 years with shorter working hours are more likely to have cardiovascular disease.

RESUMEN Objetivo: evaluar el riesgo cardiovascular en trabajadores de enfermería de un hospital público. Método: estudio transversal, con 324 trabajadores de enfermería, utilizando un cuestionario compuesto por dos bloques de información. El primero abordó cuestiones relacionadas con las características sociodemográficas y laborales y de salud, y el segundo, el Puntaje de Riesgo de Framingham revisada (ERF), para estratificar el riesgo cardiovascular. Para evaluar el estrés psicosocial en el trabajo se utilizó la Escala Sueca de Demanda de Control Social. Resultados: factor de riesgo modificable más prevalente para ECV fue el perímetro de cintura (75,9%), seguido del sobrepeso (43,8%), obesidad (29,3%), consumo de alcohol (21,9%), colesterol unido a lipoproteínas de baja densidad (LDL) > 130 (20,7%) e Hipertensión Arterial Sistémica (20,4%). Conclusión: se encontró que el 96% de los trabajadores tenían bajo riesgo de desarrollar enfermedad cardiovascular en los próximos diez años, y los trabajadores de sexo masculino > 40 años con jornadas laborales más cortas tienen mayor probabilidad de tener enfermedad cardiovascular.

OBJECTIVES: To describe retrospectively severe hospitalized cases and deaths related to the COVID-19 epidemic in the state of São Paulo, starting from the date of the first record with symptoms onset on 02/10/2020 up to 05/20/2021 records. METHODS: This is a descriptive study. The data source used was from the Influenza Epidemiological Surveillance System (SIVEP-Gripe). The rates of incidence, mortality and accumulated incidence in the period were calculated, stratified by age group and Regional Health Department (DRS). In addition, severe cases were geocoded to analyze their spread across the state; and the Effective R, which determines the spread potential of a virus within a population, was calculated. RESULTS: There was a significant increase in severe cases and deaths recorded in the period of one year, with incidence and mortality rates being heterogeneous within the state. The most critical periods regarding the incidence of severe cases occurred between May and July 2020 and between March and April 2021. The DRSs in São José do Rio Preto, Grande São Paulo and Araçatuba concentrated the highest incidence and mortality rates. Severe cases and deaths were more frequent in men and in the population over 60 years, while the main risk conditions related to deaths were heart disease (59%) and diabetes (42,8%). CONCLUSIONS: These results not only provide a detailed profile for more efficient control action plan, but will also allow the historical understanding of the COVID-19 evolution within the state of São Paulo.

OBJETIVOS: Descrever, de forma retrospectiva, os casos graves hospitalizados e óbitos relacionados à epidemia de COVID-19 no estado de São Paulo, desde a data do primeiro registro com início de sintomas em 10/02/2020 até registros disponíveis em 20/05/2021. MÉTODOS: Trata-se de um estudo descritivo realizado por meio da base de dados do Sistema de Vigilância Epidemiológica da Gripe (SIVEP-Gripe). Foram calculadas as taxas de incidência, mortalidade e incidência acumulada no período, estratificadas por faixa etária e Departamento Regional de Saúde (DRS). Os casos graves foram geocodificados para análise de seu espalhamento pelo estado e foi calculado o R Efetivo, que estima o potencial de propagação de um vírus dentro de uma população. RESULTADOS: Houve um aumento significativo dos casos graves e óbitos registrados no período de um ano, sendo que as taxas de incidência e mortalidade foram heterogêneas dentro do estado. Os períodos mais críticos em relação à incidência de casos graves ocorreram entre maio e julho de 2020 e entre março e abril de 2021. Os DRS de São José do Rio Preto, Grande São Paulo e Araçatuba concentraram as maiores taxas de incidência e mortalidade. Os casos graves e óbitos foram mais frequentes nos homens e na população acima de 60 anos, e as principais condições de risco relacionadas aos óbitos foram cardiopatia (59%) e diabetes (42,8%). CONCLUSÕES: Espera-se que esses resultados ofereçam embasamento e possam contribuir para uma ação de controle mais eficiente, além de permitir o entendimento histórico da evolução da COVID-19 no estado.

The death of professor Rolf Huisgen (1920-2020) was announced on March 26th 2020, in the midst of the COVID-19 pandemic. Professor Huisgen was professor emeritus at the University of Munich in Germany, and studied in detail the mechanism of the 1,3-dipolar cycloaddition reaction, significantly expanding its scope. Even though he did not discover this reaction, it was through his studies that it became important in organic synthesis. Indeed, in honor of his work, the reaction became known as Huisgen’s cycloaddition and it has been consolidated as a useful method for the preparation of five-membered heterocyclic compounds. Considering these facts, in this review we provide an overview on the applications of 1,3-dipolar cycloaddition reactions, starting with the seminal examples in the field and further discussing the most recent applications.

RESUMO: Objetivo: Descrever, de forma retrospectiva, os casos graves de pacientes hospitalizados e os óbitos relacionados à epidemia de COVID-19 no estado de São Paulo, desde a data do primeiro registro, com início de sintomas em 10 de fevereiro de 2020 até registros disponíveis em 20 de maio de 2021. Métodos: Trata-se de um estudo descritivo realizado por meio da base de dados do Sistema de Vigilância Epidemiológica da Gripe. Foram calculadas as taxas de incidência, mortalidade e incidência acumulada no período, estratificadas por faixa etária e agrupadas de acordo com cada Departamento Regional de Saúde. Os casos graves foram geocodificados para a análise de seu espalhamento pelo estado e foi calculado o R efetivo, que estima o potencial de propagação de um vírus em uma população. Resultados: Houve aumento significativo dos casos graves e óbitos registrados no período de um ano, e as taxas de incidência e mortalidade foram heterogêneas no estado. Os períodos mais críticos em relação à incidência de casos graves ocorreram entre maio e julho de 2020 e entre março e abril de 2021. Os Departamentos Regionais de Saúde de São José do Rio Preto, Grande São Paulo e Araçatuba concentraram as maiores taxas de incidência e mortalidade. Os casos graves e óbitos foram mais frequentes nos homens e na população acima de 60 anos, e as principais condições de risco relacionadas aos óbitos foram cardiopatia (59%) e diabetes (42,8%). Conclusões: Espera-se que esses resultados ofereçam embasamento e possam contribuir para uma ação de controle mais eficiente da COVID-19, além de permitir o entendimento histórico de sua evolução no estado.

ABSTRACT: Objectives: To retrospectively describe severe cases of hospitalized patients and deaths related to the COVID-19 epidemic in the state of São Paulo, starting from the date of the first record, with symptoms onset on 02/10/2020 up to 05/20/2021. Methods: This is a descriptive study carried out using the Influenza Epidemiological Surveillance System (Sistema de Vigilância Epidemiológica da Gripe - SIVEP-Gripe) database. The rates of incidence, mortality, and accumulated incidence in the period were calculated, stratified by age group and Regional Health Department (RHD). In addition, severe cases were geocoded to analyze their spread across the state; and the Effective R, which determines the spread potential of a virus within a population, was calculated. Results: There was a significant increase in severe cases and deaths recorded in the period of one year, with incidence and mortality rates being heterogeneous within the state. The most critical periods regarding the incidence of severe cases occurred between May and July 2020 and between March and April 2021. The RHD in São José do Rio Preto, Expanded São Paulo, and Araçatuba concentrated the highest incidence and mortality rates. Severe cases and deaths were more frequent in men and in the population over 60 years, while the main risk conditions related to deaths were heart disease (59%) and diabetes (42,8%). Conclusions: These results not only provide a detailed profile for more efficient control action plan, but will also allow the historical understanding of the COVID-19 evolution within the state of São Paulo.

RESUMO: Objetivo: Descrever, de forma retrospectiva, os casos graves de pacientes hospitalizados e os óbitos relacionados à epidemia de COVID-19 no estado de São Paulo, desde a data do primeiro registro, com início de sintomas em 10 de fevereiro de 2020 até registros disponíveis em 20 de maio de 2021. Métodos: Trata-se de um estudo descritivo realizado por meio da base de dados do Sistema de Vigilância Epidemiológica da Gripe. Foram calculadas as taxas de incidência, mortalidade e incidência acumulada no período, estratificadas por faixa etária e agrupadas de acordo com cada Departamento Regional de Saúde. Os casos graves foram geocodificados para a análise de seu espalhamento pelo estado e foi calculado o R efetivo, que estima o potencial de propagação de um vírus em uma população. Resultados: Houve aumento significativo dos casos graves e óbitos registrados no período de um ano, e as taxas de incidência e mortalidade foram heterogêneas no estado. Os períodos mais críticos em relação à incidência de casos graves ocorreram entre maio e julho de 2020 e entre março e abril de 2021. Os Departamentos Regionais de Saúde de São José do Rio Preto, Grande São Paulo e Araçatuba concentraram as maiores taxas de incidência e mortalidade. Os casos graves e óbitos foram mais frequentes nos homens e na população acima de 60 anos, e as principais condições de risco relacionadas aos óbitos foram cardiopatia (59%) e diabetes (42,8%). Conclusões: Espera-se que esses resultados ofereçam embasamento e possam contribuir para uma ação de controle mais eficiente da COVID-19, além de permitir o entendimento histórico de sua evolução no estado.

ABSTRACT: Objectives: To retrospectively describe severe cases of hospitalized patients and deaths related to the COVID-19 epidemic in the state of São Paulo, starting from the date of the first record, with symptoms onset on 02/10/2020 up to 05/20/2021. Methods: This is a descriptive study carried out using the Influenza Epidemiological Surveillance System (Sistema de Vigilância Epidemiológica da Gripe - SIVEP-Gripe) database. The rates of incidence, mortality, and accumulated incidence in the period were calculated, stratified by age group and Regional Health Department (RHD). In addition, severe cases were geocoded to analyze their spread across the state; and the Effective R, which determines the spread potential of a virus within a population, was calculated. Results: There was a significant increase in severe cases and deaths recorded in the period of one year, with incidence and mortality rates being heterogeneous within the state. The most critical periods regarding the incidence of severe cases occurred between May and July 2020 and between March and April 2021. The RHD in São José do Rio Preto, Expanded São Paulo, and Araçatuba concentrated the highest incidence and mortality rates. Severe cases and deaths were more frequent in men and in the population over 60 years, while the main risk conditions related to deaths were heart disease (59%) and diabetes (42,8%). Conclusions: These results not only provide a detailed profile for more efficient control action plan, but will also allow the historical understanding of the COVID-19 evolution within the state of São Paulo.

Resumo O objetivo deste estudo foi realizar uma revisão integrativa da literatura brasileira sobre as aplicações da Psicologia Positiva no desenvolvimento infantil. Efetuou-se uma busca por artigos científicos nas bases de dados SciELO e PePSIC, com os termos psicologia positiva, resiliência, otimismo, habilidades sociais, bem-estar e felicidade articulados aos termos desenvolvimento infantil, crianças e infância. Foram recuperadas 202 publicações entre os anos 2000 e 2019, entre estas 72 foram analisadas. Observou-se o aumento da produção científica, com destaque para o construto habilidades sociais. Houve predomínio de pesquisas empíricas e análises quantitativas. Contudo, verificou-se poucos estudos sobre a eficácia de intervenções. Conclui-se que é importante diversificar os construtos investigados e investir em desenvolvimento e validação de instrumentos de avaliação e intervenções em diferentes contextos, que proporcionem a potencialização das qualidades humanas na infância em caráter de prevenção e promoção de saúde mental ao longo da vida.

Abstract This study aimed to perform an integrative review of the Brazilian literature on the applications of Positive Psychology in child development. We searched for scientific articles using the SciELO and PePSIC electronic databases, with the terms Positive Psychology, resilience, optimism, social skills, well-being, and happiness articulated to the terms child development, children, and childhood. A total of 202 publications were retrieved between 2000 and 2019, among which 72 were analyzed. We observed an increase in the scientific production on the field, especially about the social skills construct. There was a predominance of empirical research and quantitative analyses. However, there were few studies on the effectiveness of interventions. It was concluded that it is important to diversify the investigated constructs and to invest in the development and validation of evaluation instruments and interventions in different contexts that provide the enhancement of human qualities in childhood for the prevention and promotion of mental health throughout life.

Resumen El objetivo de este estudio fue realizar una revisión integradora de la literatura brasileña sobre las aplicaciones de la Psicología Positiva en el desarrollo infantil. Se realizó una búsqueda de artículos científicos en las bases de datos SciELO y PePSIC, con los términos Psicología Positiva, resiliencia, optimismo, habilidades sociales, bienestar y felicidad, articulados con los términos desarrollo infantil, niños e infancia. Se recuperaron 202 publicaciones entre los años 2000 y 2019, entre esas 72 fueron analizadas. Se observó aumento en la producción científica, con destaque para el constructo habilidades sociales. Predominó la investigación empírica y análisis cuantitativo. Sin embargo, ha habido pocos estudios sobre eficacia de las intervenciones. Se concluye que es importante diversificar los constructos investigados e investir en desarrollo y validación de instrumentos de evaluación e intervenciones en diferentes contextos, que proporcionen mejora en las cualidades humanas en la infancia, en el campo de la prevención y promoción de salud mental a lo largo de la vida.

ABSTRACT Objective to highlight the concerns experienced by patients with advanced cancer. Methodology qualitative study developed with 11 cancer patients in palliative care. The data were collected in Maringá - PR, from 2016 to 2017, through open interviews, addressing the experiences and confrontations experienced during the terminal life process, from which the speeches were extracted and submitted to content analysis after approval by the Committee Research Ethics. Results the fear of becoming a nuisance and the uncertainties of how life will continue after his departure, were hegemonic issues of the patients, who found in the acceptance of death a moment of reflection on life, emerging as a positive probability of resilience and hope. Conclusion the main concerns expressed were: to live better now, to get closer to those who do them well, worrying about the well-being of their families and how they will be after their departure, thus transcending their own suffering.

RESUMEN Objetivo resaltar las preocupaciones experimentadas por los pacientes con cáncer avanzado. Metodología estudio cualitativo desarrollado con 11 pacientes con cáncer en cuidados paliativos. Los datos se recopilaron en Maringá - PR, de 2016 a 2017, a través de entrevistas abiertas, abordando las experiencias y confrontaciones experimentadas durante el proceso de vida terminal, de donde se extrajeron los discursos y se sometieron a análisis de contenido después de la aprobación del Comité Ética de Investigación. Resultados el miedo a convertirse en una molestia y las incertidumbres de cómo continuará la vida después de su partida, fueron problemas hegemónicos de los pacientes, quienes encontraron en la aceptación de la muerte un momento de reflexión sobre la vida, emergiendo como una probabilidad positiva de resiliencia y Espero Conclusión las principales preocupaciones expresadas fueron: vivir mejor ahora, acercarse a quienes son buenos para ellos, preocuparse por el bienestar de su familia y cómo estarán después de su partida, trascendiendo así su propio sufrimiento.

RESUMO Objetivo evidenciar as preocupações vivenciadas por pacientes com câncer em estágio avançado. Metodologia estudo qualitativo desenvolvido com 11 pacientes oncológicos em cuidados paliativos. Os dados foram coletados em Maringá – PR, no período de 2016 a 2017, mediante entrevistas abertas, abordando as experiências e enfrentamentos vivenciados durante o processo de terminalidade da vida, das quais foram extraídos os discursos e submetidos à análise de conteúdo após aprovação pelo Comitê de Ética em Pesquisa. Resultados o medo de tornar-se um incômodo e as incertezas de como a vida continuará após sua partida foram questões hegemônicas dos pacientes, que encontraram na aceitação da morte um momento de reflexão sobre a vida, despontando como uma probabilidade positiva de resiliência e esperança. Conclusão as principais preocupações manifestadas foram: viver melhor o agora, aproximar-se mais daqueles que lhes fazem bem, preocupando-se com o bem-estar de seus familiares e como eles ficarão após sua partida, transcendendo assim o seu próprio sofrimento.

ABSTRACT Naphthoquinones are the most commonly occurring type of quinones in nature. They are a diverse family of secondary metabolites that occur naturally in plants, lichens and various microorganisms. This subgroup is constantly being expanded through the discovery of new natural products and by the synthesis of new compounds via innovative techniques. Interest in quinones and the search for new biological activities within the members of this class have intensified in recent years, as evidenced by the evaluation of the potential antimicrobial activities of quinones. Among fungi of medical interest, yeasts of the genus Candida are of extreme importance due to their high frequency of colonization and infection in humans. The objective of this review is to describe the development of naphthoquinones as antifungals for the treatment of Candida species and to note the most promising compounds. By using certain criteria for selection of publications, 68 reports involving both synthetic and natural naphthoquinones are discussed. The activities of a large number of substances were evaluated against Candida albicans as well as against 7 other species of the genus Candida. The results discussed in this review allowed the identification of 30 naphthoquinones with higher antifungal activities than those of the currently used drugs.