ABSTRACT Objective: To analyze the incidence of malaria among indigenous people associated with the presence of artisanal miningin the state of Pará. Method: Analytical, cross-sectional study conducted with 20,774 cases of malaria in indigenous people in the state of Pará (2011 to 2020). The data came from the Malaria Epidemiological Surveillance Information System, obtained from the Pará State Department of Public Health. In the analysis, Spearman’s correlation coefficient was used, with a significance of 5% (p < 0.05). Results: Incidence rates were high, especially in the Tapajós River Indigenous Special Health District (372.2/1,000 inhabitants). There was association between the incidence of malaria and the presence of indigenous people in artisanalmining activities on the Tapajós River (p=0.0008). Conclusion: The occurrence of malaria is unequal among the Special Indigenous Health Districts, being more frequent in those with greater mining activity, configuring exposure to the disease. It is necessary to adopt intersectoral measures, especially in areas of vulnerability to illness.

RESUMEN Objetivo: Analizar la incidencia de malaria entre indígenas asociada a la presencia de la minería en el estado de Pará. Método: Estudio transversal analítico realizado con 20.774 casos de malaria entre indígenas del estado de Pará (2011 a 2020). Los datos provienen del Sistema de Información de Vigilancia Epidemiológica de la Malaria, obtenidos de la Secretaría de Salud Pública del Estado de Pará. En el análisis se utilizó el coeficiente de correlación de Spearman, con una significación del 5% (p < 0,05). Resultados: Las tasas de incidencia fueron altas, especialmente en el Distrito Sanitario Especial Indígena Río Tapajós (372,2/1.000 habitantes). Hubo asociación entre incidencia de malaria y la presencia de indígenas en las minas del Río Tapajós (p=0,0008). Conclusión: La ocurrencia de malaria es desigual entre los Distritos Especiales de Salud Indígena, siendo más frecuente en aquellos con mayor actividad minera, configurando la exposición a la enfermedad. Es necesario adoptar medidas intersectoriales, especialmente en áreas de vulnerabilidad a la enfermedad.

RESUMO Objetivo: Analisar a incidência da malária entre indígenas associada à presença de garimpos no estado do Pará. Método: Estudo analítico, transversal, realizado com 20.774 casos de malária em indígenas do estado do Pará (2011 a 2020). Os dados foram oriundos do Sistema de Informação de Vigilância Epidemiológica da Malária, obtidos na Secretaria de Estado de Saúde Pública do Pará. Na análise, utilizou-se o coeficiente de correlação de Spearman, com significância de 5% (p < 0,05). Resultados: As taxas de incidência se mostraram elevadas, com destaque ao Distrito Sanitário Especial Indígena Rio Tapajós (372,2/1.000 habitantes). Houve associação entre incidência da malária e a presença dos indígenas nos garimpos no Rio Tapajós (p=0,0008). Conclusão: A ocorrência da malária é desigual entre Distritos Sanitários Especiais Indígenas, sendo mais incidente naqueles de maior atividade garimpeira, configurando exposição à doença. Faz-se necessária a adoção de medidas intersetoriais, sobretudo em áreas de vulnerabilidade ao adoecimento.

Abstract Tecoma stans is popularly known as ipê-mirim in Brazil. This species belongs to the Bignoniaceae family and it is native to Americas and Antilles, where it is widely used in landscaping as urban tree. The seedlings are produced from seeds and there are several factors that influences its development, such as the sowing time and the substrate. This work aimed to understand the effect of the sowing time and substrates on the production of Tecoma stans seedlings. The experiments were carried out in a nursery. The experimental design was completely randomized. The substrates were arranged in a 2 × 6 factorial scheme, two sowing times (autumn and spring) and six commercial substrates (SC1; SC2; SC3; SC4; sand and vermiculite) under four replicates and ten seedlings per plot. The means were compared to each other using the Tukey test (p < 0.05). There was a significant difference between the seasons of the year, showing that the percentage of emergence was higher in spring (89%). The seedlings of Tecoma stans were shown to be nutrient-dependent both in the emergence of the seedling and in the subsequent development of the seedlings, since the highest averages of the studied characteristics were obtained in the commercial substrates, as they have nutrients in their composition, with greater emphasis on SC1.

Resumo Tecoma stans, popularmente conhecida como ipê-mirim é uma espécie arbórea pertencente à Família Bignoniaceae. Nativa nas Américas e Antilhas, é amplamente utilizada no Brasil, no paisagismo e na arborização urbana. A produção de suas mudas é feita por sementes e são vários os fatores que interferem neste processo e no seu posterior desenvolvimento como a época de semeadura e o substrato. O objetivo deste trabalho foi avaliar o efeito da época de semeadura e do substrato na produção de mudas de Tecoma stans. Os experimentos foram conduzidos em viveiro. O delineamento experimental foi inteiramente casualizado. Os tratamentos foram arranjados em esquema fatorial 2 × 6 sendo duas épocas de semeadura (outono e primavera) e seis substratos (SC1; SC2; SC3; SC4; areia e vermiculita); foram quatro repetições e dez plântulas por parcela. Avaliou-se a porcentagem de emergência e variáveis morfológicas. As médias foram comparadas entre si por meio do teste de Tukey (p < 0,05). Verificou-se diferença significativa entre as épocas do ano mostrando que a porcentagem de emergência foi superior na primavera (89%). As mudas de Tecoma stans se mostraram ser dependentes de nutrientes tanto na emergência da plântula como no posterior desenvolvimento das mudas, já que estes possuem nutrientes em sua composição, com destaque superior para SC1.

Abstract: The aim of this study was to analyze and compare the immunohistochemical expression of plasminogen activator system (PAS) proteins (uPA, uPAR, and PAI-1) in ameloblastomas (AMBs), odontogenic keratocysts (OKCs), and dental follicles (DFs) representing normal odontogenic tissue, as well as to investigate possible correlations between these proteins. Twenty AMBs, 20 OKCs, and 10 DFs were selected for immunohistochemical analysis. In each case, the immunoexpression of uPA, uPAR, and PAI-1 was evaluated semiquantitatively based on the percentage of positivity in odontogenic epithelial and connective tissue cells. The epithelial immunoexpression of uPA was significantly lower in AMBs when compared to OKCs (p = 0.001) and DFs (p = 0.029). Significantly higher epithelial immunostaining for uPAR was observed in AMBs when compared to OKCs (p < 0.001). There were no significant differences in the epithelial immunoexpression of PAI-1 between AMBs and OKCs (p = 1.000). The correlations found for the expression of the studied proteins were not statistically significant (p > 0.05). However, the epithelial and connective tissue expressions of uPAR have a strong positive and statistically significant correlation in AMBs. The present results suggest that uPA is involved in the pathogenesis of OKCs and that uPAR may participate in tumorigenesis in AMBs. The high percentage of PAI-1-positive cells suggests a possible role for this protein in the development of AMBs and OKCs. Furthermore, the studied proteins do not seem to act synergistically in AMBs, OKCs, and DFs.

RESUMO O jogo de Tênis de Mesa não envolve grandes deslocamentos do praticante no ambiente, característica que pode promover maior segurança ao idoso em termos locomotores. Além disso, precisa de coordenação, agilidade, velocidade de reação, equilíbrio dinâmico, que têm sido foco das atuais recomendações de atividade física para a saúde de adultos e idosos. O objetivo deste estudo é investigar os efeitos da prática de tênis de mesa na aptidão física e funcional de idosos. Esta pesquisa apresenta delineamento quase experimental com um desenho paralelo e controlado. A amostra foi composta por 16 idosos, alocados 8 no grupo experimental (GE) e 8 no grupo controle (GC). A pesquisa teve duração de 18 semanas, sendo 2 semanas de avaliação (inicial e final) e 16 semanas de intervenção. As avaliações da aptidão física foram realizadas por meio dos testes de agilidade e equilíbrio e aptidão funcional. Na comparação intragrupo (pré-pós intervenção), o GE apresentou diferença significativa para a variável agilidade (pré: 15,6 ± 1,2 s; pós: 14,7 ± 0,7s). Além disso, o GE apresentou redução na Área (pré: 11,00±3,32 cm2; pós: 6,52±3,06 cm2), Amplitude AP (pré: 4,92±2,77 cm; pós: 3,28±0,58 cm) e velocidade ML (pré: 2,77±1,07 cm/s; pós: 2,31±1,03 cm/s) na postura Tandem com os olhos abertos. Nossos achados destacam a importância de um programa de Tênis de Mesa, administrado duas vezes por semana e composto por atividades de baixa a moderada intensidade, para promover um efeito benéfico na agilidade e equilíbrio de idosos fisicamente ativos.

ABSTRACT The Table Tennis game does not involve large displacements by the practitioner in the environment, a characteristic that can promote greater safety for the elderly in locomotor terms. In addition, it needs coordination, agility, speed of reaction, dynamic balance, which have been the focus of current recommendations of physical activity for the health of adults and the elderly. The aim of this study is to investigate the effects of table tennis practice on physical and functional fitness in the elderly. This quasi-experimental research with a parallel and controlled design. The sample consisted of 16 elderly people, allocated 8 in the experimental group (EG) and 8 in the control group (CG). The research lasted 18 weeks, with 2 weeks of evaluation (initial and final) and 16 weeks of intervention. Physical fitness assessments were carried out using the agility and balance and functional fitness tests. In the intra-group comparison (pre-post intervention), EG showed a significant difference for the variable agility (pre: 15.6 ± 1.2 s; post: 14.7 ± 0.7 s). Also, the EG showed a reduction in Area (pre: 11.00±3.32 cm2; post: 6.52±3.06 cm2), AP Amplitude (pre: 4.92±2.77 cm; post: 3.28±0.58 cm) and ML speed (pre: 2.77±1.07 cm/s; post: 2.31±1.03 cm/s) in the Tandem posture with eyes open. Our findings highlight the importance of a Table Tennis program, administered twice a week and consisted of low to moderate intensity activities, to promote a beneficial effect on the agility and balance of physically active elderly people.

SUMMARY CHARGE syndrome is a complex disorder involving multiple congenital anomalies and is caused by heterozygous mutations in the CHD7 gene. Growth retardation is a characteristic finding and about 10% of cases present growth hormone (GH) deficiency. GH treatment of short stature in CHARGE syndrome has shown some benefit, but normal height is rarely attained. We report a girl with CHARGE syndrome due to a de novo frameshift mutation in the CHD7 gene (c.2509_2512delCATT), in whom recurrent hypoglycaemia led to the diagnosis of GH deficiency in the second month of life. Early initiation of treatment with recombinant GH resulted in normal growth over ten years of follow-up. This case is the youngest reported CHARGE patient to be diagnosed and treated for GH deficiency and demonstrates that GH deficiency in CHARGE syndrome may manifest early in life through hypoglycaemia, before growth retardation is noted, and can be successfully treated with recombinant GH.

Resumo Artéria labial de calibre persistente (ALCP) consiste em uma parte dilatada do ramo principal da artéria labial que penetra no tecido submucoso sem perda de calibre. O objetivo desse estudo é relatar um caso de uma paciente diagnosticada com ALCP em lábio superior, enfatizando os achados histopatológicos e imuno-histoquímicos incomuns. Paciente de 67 anos, sexo feminino, com queixa de lesão em lábio superior, pulsante, sem sintomatologia dolorosa. Diante do diagnóstico clínico de ALCP, e considerando que a paciente era edêntula e usuária de prótese total, foi realizada biópsia excisional para evitar futuros traumas na região e, consequentemente, sangramento local exuberante. Ao exame anatomopatológico foram visualizadas estruturas sugestivas de folículos linfoides e com formações sugestivas de centros germinativos. No exame imuno-histoquímico observou-se imunopositividade para CD20, CD68, desmina e CD34 e sem imunomarcação para CD4. A paciente relatou não possuir histórico de alergias, doenças cardiovasculares, reumáticas ou sistêmicas que justificassem os achados. O caso apresenta estruturas histopatológicas incomuns, corroborando a necessidade de mais estudos acerca dessa lesão tão pouco discutida na literatura.

Abstract Caliber persistent labial artery (CPLA) consists in a dilated portion of the main branch of the labial artery without loss of size. The aim of this study is to report a case of a patient diagnosed with CPLA in the upper lip, emphasizing unusual histopathological and immunohistochemical findings. A 67-year-old female patient with complaint of a pulsating upper lip lesion without painful symptomatology. Under a clinical diagnosis of CPLA, and considering that the patient was edentulous and used a total prosthesis, an excisional biopsy of the lesion was performed to avoid future traumas in the region and consequently possible exuberant local bleeding. At anatomopathological examination structures suggestive of lymphoid follicles and germinal centers were visualized. Immunohistochemistry showed positivity for CD20, CD68, desmin and CD34 and negativity for CD4. The patient did not have a history of allergies, cardiovascular, rheumatic or systemic diseases that could justified the findings. The case presents unusual histopathological structures, evidencing the necessity of more studies about this pathology so scarce in the literature.

Abstract The reduction of natural resources combined with a substantial increase in the generation of solid waste in large urban centers, justifies the search for methods of reusing the construction industry waste. The ceramic industry has a high disposal rate during the manufacturing, transportation and eventual replacement of its products. In this case, research on the reuse of ceramic materials is urgent. A possible solution is the employment of ceramic waste as a coarse aggregate in structural concrete. Therefore, the mechanical properties of this new mix of concrete have to be assessed. This study evaluates the bond strength between steel rebar and concrete with ceramic waste aggregates, by means of the pull-out test method, proposed by RILEM-FIP-CEB (1978). Three concrete mixtures were produced: a mixture without any replacement, and two other mixtures with gradual substitution of natural coarse aggregate by ceramic coarse aggregate (40% and 100% substitution, in volume). Nine cylindrical specimens, three for each of the concrete mixtures, were evaluated in laboratorial conditions. Results concerning bond stress between concrete and steel rebar indicated the feasibility of employing ceramic waste to replace part of the coarse aggregate in structural concrete.

Introdução: A Perturbação de Hiperatividade e Défice de Atenção (PHDA) é considerada a patologia neurocomportamental mais prevalente na infância, atingindo cerca de 3 a 7% das crianças em idade escolar. A intervenção terapêutica tem por objetivo principal o desenvolvimento de um equilíbrio emocional e a otimização do desempenho académico, ocupacional e relacional. Preconiza-se uma abordagem terapêutica multimodal, incluindo intervenções psicológicas e pedagógicas, farmacológicas e nutricionais. O papel da dieta como tratamento da PHDA é controverso, mas o tópico continua a interessar aos pais e profissionais de saúde, que preferem uma alternativa/complementaridade à medicação instituída. Objetivo: Esclarecer se existe evidência acerca da restrição dietética de açúcares no controlo da sintomatologia da PHDA. Metodologia: Em março de 2016 foi efetuada uma pesquisa bibliográfica utilizando os termos MESH “Attention Deficit Disorder with Hyperactivity” e “Dietary Carbohydrates” em diversas bases de dados, de artigos escritos em inglês, português ou espanhol, e publicados nos últimos 15 anos. Como critérios de inclusão foi definida uma população de crianças e adolescentes (<18 anos) com PHDA, cuja intervenção avaliasse a restrição de açúcares simples na alimentação em comparação com placebo ou metilfenidato, e um outcome na melhoria da sintomatologia. Para avaliar a qualidade dos estudos e a força de recomendação foi utilizada a escala Strength of Recommendation Taxonomy (SORT), da American Family Physician. Resultados: A pesquisa efetuada resultou na identificação de um total de 54 artigos. Foram excluídos os artigos repetidos, aqueles em que se verificou discordância com o objetivo da revisão e aqueles que não cumpriam a totalidade dos critérios de inclusão. Deste modo, foram incluídos e analisados três artigos: um estudo observacional e duas revisões não sistemáticas. Discussão: Verificou-se uma grande heterogeneidade nos estudos apresentados, assim como uma fragilidade no desenho dos trabalhos. Reconhece-se a dificuldade em conduzir ensaios clínicos bem estruturados, relativos à alimentação, pela necessidade de ter em conta múltiplos fatores passíveis de interferência. Atualmente a evidência disponível é insuficiente para sugerir que a restrição do consumo de açúcares refinados poderá melhorar os sintomas da PHDA (SORT C).

Introduction: Attention Deficit Hyperactivity Disorder (ADHD) is considered the most prevalent neurobehavioral pathology in infancy, affecting about 3 to 7 % of children in school age. The main goal of therapeutic intervention is the development of an emotional equilibrium and the optimization of the academic, occupational and relational performance. A multimodal therapeutic approach is favoured, including psychological and pedagogical interventions, as well as pharmacological and nutriti-onal. The role of diet as a treatment for ADHD is still controversial, but the topic continues to interest parents and health professionals that prefer an alternative or a complement to the given medication. Goal: To elucidate if there is evidence to support the dietary restriction to sugars in the control of the symptomatology of ADHD. Methodology: In March 2016 a literature search was done using the MESH terms “Attention Deficit Disorder with Hyperactivity” and “Dietary Carbohydrates” in different databases, for articles written in English, Portuguese or Spanish, and published in the last 15 years. The following inclusion criteria were defined: a population of children and teenagers (< 18 years old) with ADHD; an intervention that would evaluate the restriction of simple sugars in the diet of this group, in comparison to a placebo or methylphenidate; and an outcome in the improvement of the symptomology. In order to evaluate the quality of the studies and the strength of the recommendation for the dietary restriction of sugars, the Strength of Recommendation Taxonomy (SORT) scale, from the American Family Physician, was used. Results: The search resulted in a total of 54 articles. The repeated articles, those that disagreed with the goal of the revision and those that did not fulfil all the inclusion criteria, were excluded. Thus, three articles were included and analysed: an observational study and two non-systematic revisions. Discussion: A great heterogeneity in the presented studies was verified, as well as a fragility in the design of the studies. The challenge of conducting well-structured clinical trials with dietary interventions is acknowledged, as multiple factors susceptible to interference need to be taken into account. Currently, the available evidence is insufficient to suggest that a restriction to the consumption of refined sugars can lead to improvements in the symptoms of ADHD (Sort C).

O objetivo deste estudo é relatar as experiências do Programa de Educação pelo Trabalho para a Saúde (PET-Saúde) em uma maternidade pública de João Pessoa, Paraíba (PB), Brasil, pontuando as ações desenvolvidas na integração ensino-serviço. Trata-se de um estudo descritivo, do tipo relato de experiência, acerca da vivência do grupo PET-Saúde no desenvolvimento de oficinas problematizadoras com os trabalhadores, voltadas à temática da educação permanente. Temas como humanização do cuidado, integração ensino-serviço e necessidade de espaços formativos para os profissionais foram discutidos. Como desdobramento, o PET sugeriu a pactuação de uma nova dinâmica para funcionamento do Centro de Estudos da instituição e criação de um informativo para potencializar a comunicação institucional. Nota-se que a inserção do PET-Saúde no serviço possibilitou a construção de novos processos formativos, orientados na perspectiva da educação permanente.

This article documents the experiences of the Health Work Education Program ( PET-Saúde ) in a public maternity facility in João Pessoa, Brazil, highlighting teaching-service integration actions. A descriptive study was conducted to investigate the experiences of the PET-Saúde group during the development of staff workshops designed to problematize continuing education. Themes like the humanization of care, teaching-service integration, and the need for formative spaces for professionals were discussed. As a result of this process, the PET suggested the agreement of a new dynamic for the day-to-day functioning of the facility’s study center and creation of a bulletin to increase the effectiveness of institutional communication. The PET-Saúde enabled the facility to build new formative processes shaped by a continuing education perspective.

El objetivo de este estudio es relatar las experiencias del Programa de Educación por el Trabajo para la Salud (PET-Salud) en una maternidad pública de la ciudad de João Pessoa, Estado de Paraíba/PB, Brasil, puntuando las acciones desarrolladas en la integración enseñanza-servicio. Se trata de un estudio descriptivo, del tipo de relato de experiencia, sobre la vivencia del grupo PET-Salud en el desarrollo de talleres de problematización con los trabajadores, enfocados en la temática de la educación permanente. Se discutieron temas como humanización del cuidado, integración enseñanza-servicio y necesidad de espacios formativos para los profesionales. Como desdoblamiento, el PET sugirió el pacto de una nueva dinámica para funcionamiento del Centro de Estudios de la institución y creación de un informativo para potenciar la comunicación institucional. Se observa que la inserción del PET-Salud en el servicio posibilitó la construcción de nuevos procesos formativos, orientados hacia la perspectiva de la educación permanente.

O objetivo deste estudo é relatar as experiências do Programa de Educação pelo Trabalho para a Saúde (PET-Saúde) em uma maternidade pública de João Pessoa, Paraíba (PB), Brasil, pontuando as ações desenvolvidas na integração ensino-serviço. Trata-se de um estudo descritivo, do tipo relato de experiência, acerca da vivência do grupo PET-Saúde no desenvolvimento de oficinas problematizadoras com os trabalhadores, voltadas à temática da educação permanente. Temas como humanização do cuidado, integração ensino-serviço e necessidade de espaços formativos para os profissionais foram discutidos. Como desdobramento, o PET sugeriu a pactuação de uma nova dinâmica para funcionamento do Centro de Estudos da instituição e criação de um informativo para potencializar a comunicação institucional. Nota-se que a inserção do PET-Saúde no serviço possibilitou a construção de novos processos formativos, orientados na perspectiva da educação permanente.

This article documents the experiences of the Health Work Education Program ( PET-Saúde ) in a public maternity facility in João Pessoa, Brazil, highlighting teaching-service integration actions. A descriptive study was conducted to investigate the experiences of the PET-Saúde group during the development of staff workshops designed to problematize continuing education. Themes like the humanization of care, teaching-service integration, and the need for formative spaces for professionals were discussed. As a result of this process, the PET suggested the agreement of a new dynamic for the day-to-day functioning of the facility’s study center and creation of a bulletin to increase the effectiveness of institutional communication. The PET-Saúde enabled the facility to build new formative processes shaped by a continuing education perspective.

El objetivo de este estudio es relatar las experiencias del Programa de Educación por el Trabajo para la Salud (PET-Salud) en una maternidad pública de la ciudad de João Pessoa, Estado de Paraíba/PB, Brasil, puntuando las acciones desarrolladas en la integración enseñanza-servicio. Se trata de un estudio descriptivo, del tipo de relato de experiencia, sobre la vivencia del grupo PET-Salud en el desarrollo de talleres de problematización con los trabajadores, enfocados en la temática de la educación permanente. Se discutieron temas como humanización del cuidado, integración enseñanza-servicio y necesidad de espacios formativos para los profesionales. Como desdoblamiento, el PET sugirió el pacto de una nueva dinámica para funcionamiento del Centro de Estudios de la institución y creación de un informativo para potenciar la comunicación institucional. Se observa que la inserción del PET-Salud en el servicio posibilitó la construcción de nuevos procesos formativos, orientados hacia la perspectiva de la educación permanente.

Abstract Decapod crustaceans have a wide variety of feeding habits, alternating among herbivory, predation, saprophagy, and filtration. The occupation of various trophic positions in the food web is a key feature in the evolution of the group. Thus, we analyzed the natural diet of the crab Ocypode quadrata (Fabricius, 1787), commonly known as the ghost crab and typically found on sandy beaches. The crabs were collected in the region of Ubatuba, between July 2016 and May 2017. The individuals were dissected in the laboratory, and each stomach was weighed and visually assessed in relation to the degree of repletion. After identification and classification, the items found were grouped for the analysis. In analyzing the stomach contents of Ocypode quadrata, 12 items were found: sand, Insecta, Hymenoptera, Hemiptera, Coleoptera, Crustacea, and other unidentified Arthropoda. We also found poriferans, Actnopterygii bones, plant pieces, non-organic material (plastic), and other non-identified materials. In the statistical analyzes, we observed seasonal differences in the composition of the diet, mostly related to the frequency of items consumed between dry and rainy seasons; the rainy season provided a greater diversity of items. Due to the great trophic spectrum of this species and tendency to feed on a wide range of items, O. quadrata is considered a generalist species, adapting according to the availability of prey in the wild.

ABSTRACT Although the concept of optimal foraging has been extensively discussed, foraging efficiency is difficult to assess in vertebrates. In this study, we determined the foraging efficiency of the Brazilian cormorant, Nannopterum brasilianus Gmelin, 1789, by the direct, ad libitum observation of a group of four to thirteen individuals in an artificial pond at the University of São Paulo, Piracicaba, state of São Paulo, southeastern Brazil. Although this study was carried out in a highly anthropic environment, we can still conclude that the Brazilian cormorant is a relatively efficient browser and short-term diver. In anthropic environments, foraging success depends on the amount of time these birds spend diving, and stealing food is less common. Stealing occurs at relatively low rates but tends to be an efficient way to get food.

Permanent neonatal diabetes (PNDM) can result from activating heterozygous mutations in KCNJ11 gene, encoding the Kir6.2 subunit of the pancreatic ATP-sensitive potassium channels (KATP). Sulfonylureas promote KATP closure and stimulate insulin secretion, being an alternative therapy in PNDM, instead of insulin. Male, 20 years old, diagnosed with diabetes at 3 months of age. The genetic study identified a novel heterozygous mutation in exon 1 of the KCNJ11 gene – KCNJ11:c1001G>7 (p.Gly334Val) – and confirmed the diagnosis of PNDM. Therefore it was attempted to switch from insulin therapy to sulfonylurea. During glibenclamide institution C-peptide levels increased, however the suboptimal glycemic control lead us to restart an intensive insulin scheme. This new variant of KCNJ11 mutation had a phenotypic lack of response to sulfonylurea therapy. Age, prior poor metabolic control and functional change of KATP channel induced by this specific mutation may explain the observed unsuccessful switch to sulfonylurea. Interestingly, C-peptide levels raise during glibenclamide administration support some degree of improvement in insulin secretory capacity induced by the treatment. Understanding the response to sulfonylurea is crucial as successful treatment may be life-changing in these patients.