Abstract Predicting the pile’s load capacity is one of the first steps of foundation engineering design. In geotechnical engineering, there are different ways of predicting soil resistance, which is one of the main parameters. The pile load test is the most accurate method to predict bearing capacity in foundations, as it is the most accurate due to the nature of the experiment. On the other hand, it is an expensive test, and time-consuming. Over the years, semi-empirical methods have played an important role in this matter. Initially, many proposed methods were based on linear regressions. Those are still mainly used, but recently the use of a new method has gained popularity in Geotechnics: Artificial Neural Network. Over the past few decades, Machine Learning has proven to be a very promising technique in the field, due to the complexity and variability of material and properties of soils. Considering that, this work has reviewed and mapped the literature of the main papers published in journals over the last decades. The aim of this paper was to determine the main methods used and lacks that can be fulfilled in future research. Among the results, the bibliometric and protocol aiming questions such as types of piles, tests, statistic methods, and characteristics inherent to the data, indicated a lack of works in helical piles and instrumented pile load tests results, dividing point and shaft resistance. s design resistance parameters foundations experiment hand timeconsuming. timeconsuming time consuming. consuming time-consuming years semiempirical semi empirical matter Initially regressions Geotechnics Network decades field soils research results data

Background: Although the association between intraductal papillary mucinous neoplasm of the pancreas (IPMN) and pancreatic neuroendocrine tumor (PNET) has been increasingly reported, whether this association is real or coincidence remains unclear. We report a case of synchronous IPMN and a PNET which were diagnosed preoperatively and discuss the tumorigenesis, clinicopathological features and management of these rare tumors based on the published literature. Case report: A 56-year-old male was incidentally diagnosed with a 14 mm branch duct IPMN and a 3.6 mm non-functional PNET during an evaluation due to persistent upper abdominal pain via endoscopic ultrasound. Close follow-up of the patient was decided as the IPMN had no worrisome features. A review of twenty-two previously reported cases of synchronous IPMN and PNET indicated that: a) only seven cases were diagnosed preoperatively; b) abdominal pain was the main presenting symptom; c) IPMN was the dominant tumor and presented with low grade dysplasia; d) the PNET was small and non-functional and had an indolent behavior; and e) only one case underwent radiologic follow-up. Discussion: IPMN are associated with other pancreatic and extrapancreatic malignancies. Thus, the entire pancreatic parenchyma should be examined closely during the evaluation of an IPMN in order to exclude other pancreatic lesions, for example, a PNET.

Resumo Fundamento: A doença de Fabry é uma doença lisossomal de sobrecarga provocada pela deficiência da enzima α-galactosidase A como resultado de mutações no gene GLA. O envolvimento cardíaco carateriza-se por hipertrofia ventricular esquerda progressiva. Objetivo: Estimar a prevalência da doença de Fabry numa população com hipertrofia ventricular esquerda. Métodos: Os doentes foram avaliados para a presença de hipertrofia ventricular esquerda definida por massa do ventrículo esquerdo indexada como ≥ 96 g/m2 para mulheres ou ≥ 116 g/m2 para homens. Estenose aórtica severa e hipertensão arterial, com hipertrofia ventricular esquerda discreta, foram critério de exclusão. Todos os doentes incluídos foram avaliados para a atividade da enzima α-galactosidase A com testes de gota seca. No caso de atividade enzimática diminuída, realizava-se estudo genético. Resultados: Foram incluídos 47 doentes com uma média de massa indexada de 141,1 g/m2 (± 28,5; 99,2 a 228,5 g/m2]. A maioria (51,1%) dos doentes era do sexo feminino. Nove deles (19,1%) tinham diminuição da atividade da α-galactosidase A, mas apenas um teste genético foi positivo − [GLA] c.785G>T; p.W262L (éxon 5), uma mutação não descrita na literatura. O trabalho de investigação clínica permitiu estabelecer uma associação entre a mutação e a apresentação clínica. Conclusão: Em uma população de doentes com hipertrofia ventricular esquerda, documentamos uma prevalência de doença de Fabry de 2,1%. O novo caso foi definido na sequência de uma mutação de significado indeterminado no gene GLA com posterior estudo de patogenicidade. Este estudo permitiu, assim, definir uma nova mutação causal para doença de Fabry - [GLA] c.785G>T; p.W262L (éxon 5).

Abstract Background: Fabry disease is a lysosomal storage disease caused by enzyme α-galactosidase A deficiency as a result of mutations in the GLA gene. Cardiac involvement is characterized by progressive left ventricular hypertrophy. Objective: To estimate the prevalence of Fabry disease in a population with left ventricular hypertrophy. Methods: The patients were assessed for the presence of left ventricular hypertrophy defined as a left ventricular mass index ≥ 96 g/m2 for women or ≥ 116 g/m2 for men. Severe aortic stenosis and arterial hypertension with mild left ventricular hypertrophy were exclusion criteria. All patients included were assessed for enzyme α-galactosidase A activity using dry spot testing. Genetic study was performed whenever the enzyme activity was decreased. Results: A total of 47 patients with a mean left ventricular mass index of 141.1 g/m2 (± 28.5; 99.2 to 228.5 g/m2] were included. Most of the patients were females (51.1%). Nine (19.1%) showed decreased α-galactosidase A activity, but only one positive genetic test − [GLA] c.785G>T; p.W262L (exon 5), a mutation not previously described in the literature. This clinical investigation was able to establish the association between the mutation and the clinical presentation. Conclusion: In a population of patients with left ventricular hypertrophy, we documented a Fabry disease prevalence of 2.1%. This novel case was defined in the sequence of a mutation of unknown meaning in the GLA gene with further pathogenicity study. Thus, this study permitted the definition of a novel causal mutation for Fabry disease - [GLA] c.785G>T; p.W262L (exon 5).

O cancro do pulmão é a principal causa de morte por cancro nos homens. O diagnóstico pode ser tardio se a primeira apresentação for através de lesões atípicas. Nódulos subcutâneos do couro cabeludo podem representar metástases de diferentes tumores. O carcinoma epidermóide do pulmão, embora raro, deve ser considerado quando essas lesões são encontradas. No caso apresentado, a evolução das lesões e a idade jovem do paciente sugeriram uma abordagem eficaz que levaou ao diagnóstico.

Lung cancer is the leading cause of death from cancer in men. The diagnosis may be delayed if atypical lesions are the first presentation. Subcutaneous nodules of the scalp may represent metastasis from various tumors. Small cell cancer of the lung, though rare, might be considered when lesions are found. In the case presented here, the evolution of the lesions and the young age of the patient suggested an effective approach that led to the diagnosis.