Abstract Introduction: Reoperations in cardiac surgery represent a clinical challenge, particularly because of the higher rate of perioperative morbidity and mortality. Mitral valve reoperation owing to bioprosthesis dysfunction, transcatheter treatment with a prosthesis implantation over the prosthesis has emerged as an alternative, especially for patients with a previous approach. In this study, we analyzed the hydrodynamic behavior of transcatheter prosthesis implantation in conventional mitral bioprostheses through hydrodynamic tests and produced a recommendation for the size of transcatheter valve most adequate for valve-in-valve procedure. Methods: Mitral bioprostheses were attached to a flow duplicator and different combinations of transcatheter prostheses were implanted inside. The equipment simulates the hydrodynamic behavior of the valves submitted in vitro and determines transvalvular pressures and flow parameters. Results: All tests could be performed. Better hydrodynamic performance occurred for transcatheter prostheses 1 mm smaller than bioprostheses, except for the 27-mm bioprostheses. Effective valve areas (cm²) and transvalvular gradients (mmHg) were, respectively: Bioprosthesis × Inovare: 27 × 28 mm: 1.65 and 5.95/29 × 28 mm and 31 × 30 mm: 2.15 and 3.6. Conclusion: The mitral valve-in-valve implantation proved to be feasible in vitro. The use of 27-mm bioprostheses should be judicious, with preference for a 26-mm transcatheter valve. In the 29 and 31-mm bioprostheses, the implantation was very satisfactory, with good effective valve areas and transvalvular gradients, with preference for smaller transcatheter valves.

Resumo O objetivo deste trabalho foi avaliar a qualidade da carcaça em 74 ovelhas Santa Inês deslanadas com idades entre 6 a 48 meses. O abate ocorreu após jejum e eletrochoque, seguido de dissecção das veias jugulares e artérias carótidas. As avaliações realizadas foram peso de carcaça quente, rendimento de carcaça quente, comprimento de carcaça, espessura da pele, pesos e percentagens de ombro, pescoço, lombo, fralda, costelas e pernil e comprimento e perímetro do pernil. A área de olho de lombo, a cor usando o sistema CIELAB, a força de cisalhamento e a perda por cocção também foram avaliados. Os dados foram submetidos às análises de variância, regressões, correlações e de componentes principais utilizando o pacote estatístico SAS. O peso de carcaça quente foi 15,75 kg e o rendimento de carcaça foi de 43,65%. Os animais mais jovens apresentaram maior rendimento de pernil enquanto os rendimentos de lombo e ombro aumentaram com a idade. A carne foi mais escura em animais mais velhos. Com o aumento da idade, ocorreu redução na quantidade dos cortes comerciais e aumento das perdas de características de qualidade como cor, perda por cocção e força de cisalhamento; portanto, o abate deve ser realizado antes de 30 meses de idade.

Abstract The objective of this trial was to evaluate carcass quality in 74 Santa Ines hair ewes aged 6 to 48 months. Slaughter occurred after fasting and electroshock, followed by dissection of the jugular veins and carotid arteries. Hot carcass weight, hot carcass yield, carcass length, skin thickness, shoulder, neck, loin, belly, rib and leg weights and percentages, leg length, and girth were measured. The rib eye area, color (by CIELAB system), shear force, and cooking loss were also measured. The data were analyzed using SAS procedures for analysis of variance, regressions, correlations, and principal components. Hot carcass weight was 15.75 kg and yield was 43.65%. Younger animals had higher leg yield while yields of loin and shoulder increased as age increased. The meat was darker in older animals. As age increased, both the quantity of commercial cuts decreased and the loss of quality traits, such as color, cooking loss, and shear force, increased; therefore, slaughter should be performed before 30 months of age.

ABSTRACT Cottonseed coproducts contain gossypol which can have specific effects upon the male reproductive system. We evaluated the reproductive development of male lambs close to puberty fed on three cotton coproducts. Twenty-four 5-month old male lambs received four diets: 20 % of dry matter intake of whole cottonseed (WCS), high oil cottonseed meal (CSC), cottonseed meal (CSM), and a control group (CTL) without any cottonseed coproducts. Free gossypol intake was 16.32, 6.98, 5.47 and 0 mg kg−1 BW−1 d−1 for WCS, CSC, CSM and CTL, respectively. Every 15 days, the animals were weighted and serum and semen samples were collected. After 95 days, testis samples were collected for analysis under light and transmission electron microscopes. The CTL group had higher testosterone concentrations than CSC at the end of the trial and lower total sperm defects, higher mass movement and higher scores for seminiferous epithelium than other treatments. The WCS and CSC groups showed higher levels of segmental aplasia lesion in sperm than other diets, which showed that high levels of gossypol led to higher occurrence of this lesion. Cottonseed coproducts had a negative impact on the reproductive system of pubertal lambs regardless of gossypol concentration. Therefore, the use of cottonseed coproducts to feed lambs earmarked for reproduction is not safe.

ABSTRACT OBJECTIVE: Engage the UNIFESP Cardiovascular Surgery residents in coronary anastomosis, assess their skills and certify results, using the Arroyo Anastomosis Simulator and UNIFESP surgical models. METHODS: First to 6th year residents attended a weekly program of technical training in coronary anastomosis, using 4 simulation models: 1. Arroyo simulator; 2. Dummy with a plastic heart; 3. Dummy with a bovine heart; and 4. Dummy with a beating pig heart. The assessment test was comprised of 10 items, using a scale from 1 to 5 points in each of them, creating a global score of 50 points maximum. RESULTS: The technical performance of the candidate showed improvement in all items, especially manual skill and technical progress, critical sense of the work performed, confidence in the procedure and reduction of the time needed to perform the anastomosis after 12 weeks practice. In response to the multiplicity of factors that currently influence the cardiovascular surgeon training, there have been combined efforts to reform the practices of surgical medical training. CONCLUSION: 1 - The four models of simulators offer a considerable contribution to the field of cardiovascular surgery, improving the skill and dexterity of the surgeon in training. 2 - Residents have shown interest in training and cooperate in the development of innovative procedures for surgical medical training in the art.