BACKGROUND: Ruta graveolens L. (R. graveolens) is a medicinal plant employed in non-traditional medicines that has various therapeutic properties, including anthelmintic, and vasodilatory actions, among others. We evaluated the trachea-relaxant effects of hydroalcoholic extract of R. graveolens against potassium chloride (KCl)- and carbachol-induced contraction of rat tracheal rings in an isolated organ bath. RESULTS: The results showed that the airway smooth muscle contraction induced by the depolarizing agent (KCl) and cholinergic agonist (carbachol) was markedly reduced by R. graveolens in a concentration-dependent manner, with maximum values of 109 ± 7.9 % and 118 ± 2.6 %, respectively (changes in tension expressed as positive percentages of change in proportion to maximum contraction), at the concentration of 45 μg/mL (half-maximal inhibitory concentration IC50: 35.5 μg/mL and 27.8 μg/mL for KCl- and carbachol-induced contraction, respectively). Additionally, the presence of R. graveolens produced rightward parallel displacement of carbachol dose-response curves and reduced over 35 % of the maximum smooth muscle contraction. CONCLUSIONS: The hydroalcoholic extract of R. graveolens exhibited relaxant activity on rat tracheal rings. The results suggest that the trachea-relaxant effect is mediated by a non-competitive antagonistic mechanism. More detailed studies are needed to identify the target of the inhibition, and to determine more precisely the pharmacological mechanisms involved in the observed biological effects.

Vidal de La Blache foi por muito tempo, principalmente no Brasil, considerado um opositor das ideias de Friedrich Ratzel. A análise de diversos textos de Vidal mostrou que isso não existiu e que Ratzel teve influência significativa em algumas concepções do geógrafo francês. É esse fato que o artigo pretende destacar, além de expor as razões da colocação desta “rivalidade” e analisar escritos de Vidal para demonstrar o respeito que este possuía em relação a concepções do geógrafo prussiano.

For a long time, Vidal de la Blache was considered an opponent of Friedrich Ratzel’s ideas, especially in Brazil. Analysis of several Vidal’s texts has shown that it did not exist and that Ratzel had a important influence in some of the French geographer conceptions. This is the fact that the article aims to detach, besides exposing the reasons of putting this “rivalry” and analyzing Vidal’s writings to demonstrate this last one’s respect for the Prussian geographer conceptions.