Resumo O presente estudo objetivou investigar a percepção de atores profissionais idosos sobre o envelhecimento, a velhice e o significado de ser avô(ó). Trata-se de uma pesquisa exploratória, descritiva e transversal. Aplicou-se entrevista aberta com roteiro semiestruturado, sendo os dados analisados a partir da análise de conteúdo proposta por Bardin. A maioria dos atores idosos apresentou discurso revelando um envelhecimento desfavorável e a negação desse processo na vida pessoal. Todavia, no meio artístico, os entrevistados apresentaram uma imagem favorável do idoso e da juventude, destacando influência favorável da profissão ao próprio envelhecimento e à velhice. A maioria indicou uma percepção favorável sobre o significado de ser avô(ó) na vida familiar e uma postura neutra em relação à interpretação desse papel no campo profissional. Conclui-se que a profissão de ator influenciou as reflexões acerca dos diversos aspectos do envelhecimento e que a arte e as habilidades desse ofício favoreceram aos atores idosos a tendência de negar a própria velhice e de ter uma visão desfavorável sobre o envelhecimento.

Abstract The present study aimed to investigate the perception of elderly professional actors regarding aging, old age and the meaning of being a grandfather or grandmother. An exploratory, descriptive, cross-sectional study was performed. An open interview with a semi-structured script was used, and the data was analyzed with the Bardin technique. The discourse of the elderly actors revealed an unfavorable view of aging and the denial of this process in their personal lives. From an artistic perspective, however, the respondents had a favorable image of old age and youthfulness, highlighting the favorable influence of the profession on their own aging and old age. Most showed a favorable perception of the meaning of being a grandmother or grandfather in family life, and had a neutral stance on the interpretation of this role in the professional field. It can be concluded that the profession of acting influenced discussions on the various aspects of aging and that the skills of the actor's craft encouraged elderly actors to tend to deny their old age and to have an unfavorable view of aging.

The aim of this study was to evaluate the in vivo activity of the anti-inflammatory and analgesic effects of a suspension of the complex composed of dexamethasone acetate (DMA) with β-cyclodextrin in comparison to a suspension of the pure DMA. Solid complexes prepared by different methods were evaluated in pharmacodynamics and pharmacokinetics studies. The pharmacodynamic effect was investigated although the capacity of the inhibited the inflammation. Models of abdominal constriction, carrageenan-induced paw oedema and formalin induced licking were used. The study of the pharmacodynamic comparison of free DMA and products of β-CD:DMA demonstrated no significant difference in the majority of the tests performed. Plasma concentrations of DMA and DMA:β-CD were assayed by HPLC. A significant (p > 0.05) decrease in the relative bioavailability was obtained with the suspension containing the DMA:β-CD complex as measured by DMA plasma levels. The area under the curve (AUC) of the suspension of DMA was higher than that obtained with the suspension of the complexes. The pharmacokinetic evaluation of dexamethasone carried out on mice in the present study showed that complexed DMA with β-cyclodextrin modifieds some parameters related to the phases of absorption and elimination of this drug.