BACKGROUND Eosinophils are granulocytes that rapidly increase frequency in the bloodstream during helminthic infections and allergic responses. They are found in tissue infected by Leishmania during early disease, but their role during infection is not entirely understood. OBJECTIVES We aim to compare the disease due to Leishmania amazonensis in BALB/c and Δdbl-GATA1 mice, which lack eosinophils. METHODS BALB/c and Δdbl-GATA1 mice infected with L. amazonensis were observed for several weeks. The parasite load and dissemination pattern were assessed. FINDINGS The Δdbl-GATA1 mice developed an anticipated dissemination of L. amazonensis and a worsening disease. No differences were found in the lesion development or the parasite load in the footpad among Δdbl-GATA1 mice and BALB/c eight weeks after infection. However, nine weeks after infection, massive growth of metastatic lesions appeared in several parts of the skin in Δdbl-GATA1 mice, weeks earlier than BALB/c. We observed increased parasites in the bloodstream, probably an essential dissemination route. Thirteen weeks after infection, metastatic lesions were found in all Δdbl-GATA1 mice. MAIN CONCLUSION These results suggest a protective role of eosinophils in delaying the disease caused by L. amazonensis, although several limitations of this mice strain must be considered.

Penicillium meliponae, a recently described and rare species, was isolated as an endophytic fungus from the Amazonian plant Duguetia sthelechantha, and has been proven to be a pigment producer. Considering the high productivity of this species and the lack of data on its chemical composition, the present study aimed to characterize the chemical profile of P. meliponae and evaluate the influence of agitation and the use of different culture media. For this purpose, liquid chromatography coupled with mass spectrometry (LC-MS/MS) and molecular networking were used, allowing the identification of 17 azaphilone molecules with sclerotiorin-like skeletons, becoming the first chemical report of this species. In addition, the different production patterns in the tested culture media were indicative that this species is sensitive to changes in the composition of the carbon source and to the presence of agitation. Furthermore, this work contributes to the fragmentation mechanisms of the different possible structural arrangements for azaphilones of the sclerotiorin type and serves as a repository of information on the gas-phase behavior of this type of metabolite in mass spectrometry experiments and will assist future studies aimed at the discovery of azaphilones.

RESUMO: Os quistos facetários são lesões císticas benignas localizadas adjacentes a uma articulação facetária. A maioria é assintomática. No entanto, podem ser causa de importante dor lombar e radiculopatia. Estão ainda relatados casos de déficit neurogénico, claudicação e síndrome de cauda equina. Os autores apresentam dois casos de dor lombar aguda com ciatalgia bilateral, disestesia do dorso do pé e défice na dorsiflexão/extensão do hálux, causados por uma redução significativa do canal medular devido à presença de quistos encapsulados adjacentes às articulações facetarias. Os doentes foram submetidos a descompressão cirúrgica urgente com uma excelente recuperação. Os quistos facetários sintomáticas são uma causa rara de lombalgia, porém podem apresentar-se inicialmente com um quadro agudo de ciatalgia bilateral e estenose canalar com necessidade de descompressão cirúrgica urgente. Este artigo realça os quistos facetários como diagnóstico diferencial de lombalgia e descreve duas abordagens cirúrgicas diferentes com bons resultados. Nível de Evidência IV; Série de Casos. RESUMO facetária assintomática entanto radiculopatia neurogénico equina dorsiflexãoextensão dorsiflexão extensão hálux facetarias recuperação apresentarse apresentar se resultados IV Casos

RESUMEN: Los quistes facetarios son lesiones quísticas benignas situadas junto a una articulación facetaria. La mayoría es asintomática. Pero pueden causar dolor lumbar y radiculopatía importantes. También se han descrito déficit neurogénico, claudicación y síndrome de cauda equina. Los autores presentan dos casos de lumbalgia aguda con dolor ciático bilateral, disestesia del dorso del pie y déficit en la dorsiflexión/extensión del hallux, causados por una reducción significativa del canal medular debido a la presencia de quistes encapsulados adyacentes a las articulaciones facetarias. Los pacientes fueron sometidos a descompresión quirúrgica urgente con una excelente recuperación. Los quistes facetarios sintomáticos son una causa poco frecuente de lumbalgia, aunque pueden presentarse inicialmente con un cuadro agudo de dolor ciático bilateral y estenosis del canal que requiere descompresión quirúrgica urgente. Este artículo destaca los quistes facetarios como diagnóstico diferencial de la lumbalgia y describe dos abordajes quirúrgicos diferentes con buenos resultados. Nivel de Evidencia IV; Serie de Casos. RESUMEN facetaria asintomática importantes neurogénico equina dorsiflexiónextensión dorsiflexión extensión hallux facetarias recuperación resultados IV Casos

ABSTRACT Facet joint ganglia are benign cystic lesions located adjacent to a facet joint. The majority is asymptomatic. However, can cause important low-back pain and radiculopathy. Neurogenic deficit, claudication, and cauda equina syndrome have also been reported. The authors report two cases of acute low back pain with bilateral sciatica, dorsal foot dysesthesia, and hallux dorsiflexion/extension deficit, due to the presence of encapsulated cysts adjacent to the facet joints causing a significant reduction of the spinal canal. Urgent surgical decompression was performed in both patients with an uneventful recovery. Symptomatic facet joint ganglia is a highly unusual cause of back pain, although it can present with acute onset of bilateral sciatica and canal stenosis requiring urgent surgical decompression. This paper highlights facet joint synovial as a differential diagnosis of lumbar pain and describes two different surgical approaches with good outcomes. Level of Evidence IV; Case Series. asymptomatic However lowback radiculopathy deficit claudication reported dysesthesia dorsiflexionextension dorsiflexion extension recovery outcomes IV Series

RESUMO Este artigo apresenta um estudo teórico-experimental com o objetivo de determinar o coeficiente de transferência de calor interfacial, as variáveis térmicas de solidificação, os espaçamentos dendríticos primários e secundários bem como a microdureza Vickers da liga Al-11%Si solidificada direcionalmente, sob condições transientes de fluxo de calor, em um dispositivo de configuração horizontal refrigerado a água. Para o monitoramento dos perfis de temperatura utilizou-se um conjunto de termopares tipo K localizados em diferentes posições a partir da interface metal-molde, considerando a linha central correspondente ao eixo longitudinal do lingote. Uma técnica numérica, que compara perfis térmicos teóricos e experimentais, foi utilizada no cálculo do coeficiente de transferência de calor na interface metal/molde durante a solidificação cuja condição transiente é representada por uma equação analítica na forma de potência. Foram aplicadas técnicas experimentais para o cálculo das variáveis térmicas de solidificação, ou seja, deslocamento da frente de solidificação, velocidade da isoterma liquidus e taxa de resfriamento. Os resultados experimentais e simulados apresentaram uma concordância muito boa e possibilitaram estabelecer correlações analíticas entre tais variáveis térmicas e os espaçamentos dendríticos primários e secundários obtidos, por meio de equações na forma de potência representadas por expoentes característicos. Finalmente, são também apresentadas expressões experimentais capazes de correlacionar os valores dos espaçamentos dendríticos estudados com o comportamento da microdureza Vickers da referida liga.

ABSTRACT This paper presents a theoretical-experimental study aiming to determine the interfacial heat transfer coefficient and solidification thermal parameters from experimentally obtained data correlating these with the primary and secondary dendritic spacings as well as microhardness during the horizontal solidification of the Al-11wt.%Si alloy under transient heat flow conditions. For the experimental procedure, a water-cooled solidification device was used which allows the horizontal directional solidification and the monitoring of the temperature profiles in different positions from the metal-mold interface considering the center line corresponding to the longitudinal axis of the ingot. A numerical technique which compares theoretical and experimental thermal profiles has permitted the evaluation of the variation of metal-mold heat transfer coefficient along the solidification. The interfacial heat transfer coefficient of studied alloy is represented by a equation which show the time dependence during the process. The experimental and calculated values have shown a very good agreement. Experimental techniques were applied to calculate the following solidification thermal variables: solidification front displacement, growth rate and cooling rate. The experimental results allowed establishing a quantitative correlation between such thermal variables and the studied structural parameters by means of power type equations represented by characteristic exponents. Finally, correlation between the values of both primary and secondary dendritic spacings found with Vickers microhardness behavior for the studied alloy is also presented.

ABSTRACT Objectives: The severity of pulmonary Covid-19 infection can be assessed by the pattern and extent of parenchymal involvement observed in computed tomography (CT), and it is important to standardize the analysis through objective, practical, and reproducible systems. We propose a method for stratifying the radiological severity of pulmonary disease, the Radiological Severity Score (RAD-Covid Score), in Covid-19 patients by quantifying infiltrate in chest CT, including assessment of its accuracy in predicting disease severity. Methods: This retrospective, single-center study analyzed patients with a confirmed diagnosis of Covid-19 infection by real-time reverse-transcriptase polymerase chain reaction, who underwent chest CT at hospital admission between March 6 and April 6, 2020. CT scans were classified as positive, negative, or equivocal, and a radiological severity score (RAD-Covid Score) was assigned. Clinical severity was also assessed upon hospital admission. Results: 658 patients were included. Agreement beyond chance (kappa statistic) for the RAD-Covid Score was almost perfect among observers (0.833), with an overall agreement of 89.5%. The RAD-Covid Score was positively correlated with clinical severity and death, i.e., the higher the RAD-Covid Score, the greater the clinical severity and mortality. This association proved independent of age and comorbidities. Accuracy of this score was 66.9%. Conclusions: The RAD-Covid Score showed good accuracy in predicting clinical severity at hospital admission and mortality in patients with confirmed Covid-19 infection and was an independent predictor of severity.

Resumo O estudo buscou conhecer quem são os gestores municipais de saúde e práticas realizadas no âmbito de gestão. Possuiu delineamento transversal. A metodologia contou com o envio de um questionário eletrônico às secretarias de saúde dos 497 municípios do estado do Rio Grande do Sul (RS). Destes, 297 retornaram (59,75%). Contudo, foram considerados na análise estatística apenas os questionários com mais de 50% de respostas válidas (n = 264). A análise contou com o cálculo da distribuição das variáveis e com testes de qui-quadrado, onde o porte populacional foi considerado variável independente. A maioria foi composta por mulheres, com escolaridade alta e distintas formações, média de idade de 43,76 anos, cor branca. A média de gastos com saúde foi de ≈20% das receitas. Houve consenso quanto na insuficiência dos recursos. Quanto ao porte populacional, 79,92% possuíam ≤ 20.000 habitantes. Diferenças significativas foram observadas na gestão de municípios de distintos portes, tanto nas prioridades, quanto nas dificuldades. O estudo permitiu conhecer parcialmente a realidade da gestão municipal. Além disso, os resultados sugeriram a necessidade de novas pesquisas sobre a feminilização da gestão, avaliação de processos de trabalho e impactos da política de austeridade.

Abstract This study intended to gather who are the county health managers and the practices performed in management. It is based on a cross-sectional design. The methodology involved the use of electronic questionnaire, which was sent to the health departments of the 497 municipalities of the state of Rio Grande do Sul (RS). Of these, 297 were answered (59.75%). However, only those with more than 50% of valid answers (n = 264) were included in the statistical analysis. The analysis included the calculation of the distribution of variables and chi-square testes, taking population size as an independent variable. Most managers were women; graduated; from different professional backgrounds; average age of 43.76 years-old, and white. The average health expenditure in the municipalities was ≈ 20% of revenues. There was a consensus on the insufficiency of resources. With regards to population size, 79.92% presented with ≤ 20,000 inhabitants. Statistically significant differences were found in the management of municipalities of different sizes, both in terms of priorities and difficulties. The study allowed to partially understanding the reality of municipal management. These results indicate the need to further investigate the feminization of health management, working process assessment, and the impacts of economical austerity policy.

Resumo O estudo buscou conhecer quem são os gestores municipais de saúde e práticas realizadas no âmbito de gestão. Possuiu delineamento transversal. A metodologia contou com o envio de um questionário eletrônico às secretarias de saúde dos 497 municípios do estado do Rio Grande do Sul (RS). Destes, 297 retornaram (59,75%). Contudo, foram considerados na análise estatística apenas os questionários com mais de 50% de respostas válidas (n = 264). A análise contou com o cálculo da distribuição das variáveis e com testes de qui-quadrado, onde o porte populacional foi considerado variável independente. A maioria foi composta por mulheres, com escolaridade alta e distintas formações, média de idade de 43,76 anos, cor branca. A média de gastos com saúde foi de ≈20% das receitas. Houve consenso quanto na insuficiência dos recursos. Quanto ao porte populacional, 79,92% possuíam ≤ 20.000 habitantes. Diferenças significativas foram observadas na gestão de municípios de distintos portes, tanto nas prioridades, quanto nas dificuldades. O estudo permitiu conhecer parcialmente a realidade da gestão municipal. Além disso, os resultados sugeriram a necessidade de novas pesquisas sobre a feminilização da gestão, avaliação de processos de trabalho e impactos da política de austeridade.

Abstract This study intended to gather who are the county health managers and the practices performed in management. It is based on a cross-sectional design. The methodology involved the use of electronic questionnaire, which was sent to the health departments of the 497 municipalities of the state of Rio Grande do Sul (RS). Of these, 297 were answered (59.75%). However, only those with more than 50% of valid answers (n = 264) were included in the statistical analysis. The analysis included the calculation of the distribution of variables and chi-square testes, taking population size as an independent variable. Most managers were women; graduated; from different professional backgrounds; average age of 43.76 years-old, and white. The average health expenditure in the municipalities was ≈ 20% of revenues. There was a consensus on the insufficiency of resources. With regards to population size, 79.92% presented with ≤ 20,000 inhabitants. Statistically significant differences were found in the management of municipalities of different sizes, both in terms of priorities and difficulties. The study allowed to partially understanding the reality of municipal management. These results indicate the need to further investigate the feminization of health management, working process assessment, and the impacts of economical austerity policy.

Radiolabeling cidofovir with technetium-99m (99mTc-CDV) is an innovative procedure that enables real-time monitoring of the drug. Essays were performed in vitro, showing high radiolabel stability within 24 h. Blood clearance, biodistribution studies, and scintigraphic images were performed in healthy mice in order to evaluate the profile of the drug in vivo. 99mTc-CDV showed biphasic blood circulation time and significant kidney uptake, indicating that 99mTc-CDV is preferentially eliminated by the renal route. Bones also showed important uptake throughout the experiment. In summary, cidofovir was successfully labeled with technetium-99m and might be used in further studies to track the drug.

Resumo A Society for Vascular Surgery propôs nova classificação para o membro inferior ameaçado, baseada nos três principais fatores influenciadores do risco de amputação do membro: ferida (Wound, W), isquemia (Ischemia, I) e infecção do pé (foot Infection, fI): a classificação WIfI. Esta abrange também os diabéticos, anteriormente excluídos do conceito de isquemia crítica do membro devido a seu quadro clínico complexo. O objetivo da classificação era fornecer estratificação de risco precisa e precoce ao paciente com membro inferior ameaçado; auxiliar no manejo clínico, permitindo comparar terapias alternativas; e predizer o risco de amputação em 1 ano e a necessidade de revascularização. O objetivo deste estudo é reunir os principais pontos abordados sobre a classificação WIfI no meio científico. A maior parte dos estudos de validação da classificação demonstram sua associação à predição de salvamento do membro, eventos de reintervenção, amputação e estenose, taxas de amputação maior e menor, sobrevida livre de amputação, e cicatrização de feridas.

Abstract The Society for Vascular Surgery has proposed a new classification system for the threatened lower limb, based on the three main factors that have an impact on limb amputation risk: Wound (W), Ischemia (I) and foot Infection (“fI”) - the WIfI classification. The system also covers diabetic patients, previously excluded from the concept of critical limb ischemia because of their complex clinical condition. The classification’s purpose is to provide accurate and early risk stratification for patients with threatened lower limbs; assisting with clinical management, enabling comparison of alternative therapies; and predicting risk of amputation at 1 year and the need for limb revascularization. The objective of this study is to collect together the main points about the WIfI classification that have been discussed in the scientific literature. Most of the studies conducted for validation of this classification system prove its association with factors related to limb salvage, such as amputation rates, amputation-free survival, prediction of reintervention, amputation, and stenosis (RAS) events, and wound healing.

Resumo As fraturas do escafoide társico, bem como outras lesões do médiopé, são raras e podem resultar em incapacidade grave se não forem tratadas adequadamente. Parkour, um esporte moderno, está ganhando popularidade entre os jovens em áreas urbanas, e é propenso a traumatismos de alta energia, sendo estes escassamente descritos na literatura. O presente relato trata de um caso de fratura rara do escafoide társico em um paciente do sexo masculino de 17 anos, ocorrida durante a prática de parkour, que foi tratada com sucesso, com redução aberta e fixação interna. A descrição do caso enfatiza os desafios na sua abordagem; a discussão destaca as opções de tratamento e seus objetivos. O caso também deve alertar sobre a ocorrência crescente dessas lesões incomuns.

Abstract Tarsal navicular fractures, as well as other midfoot injuries, are rare, and can result in severe impairment if not properly treated. Parkour, a modern sport, is gaining popularity among young individuals in urban areas, and is prone to result in high-energy trauma, which is scarcely described in the literature. The following is a report of a rare case of tarsal navicular fracture in a 17-year-old male, sustained during parkour practice, which was treated successfully with open reduction and internal fixation. The description of the case emphasizes the challenges of its approach; the discussion highlights the treatment options and goals. The case should also raise awareness about the increasing occurrence of these uncommon lesions.

Resumo As escolas das comunidades caiçaras da Praia do Sono e do Pouso da Cajaíba, localizadas no município de Paraty (RJ), iniciaram, no ano de 2016, a oferta do ensino fundamental II com a proposta de uma educação adaptada às suas realidades. Essa iniciativa ocorre em um período em que as comunidades vêm buscando novas formas de desenvolver o turismo. O presente artigo visa discutir o processo de construção da educação escolar diferenciada e sua contribuição para o desenvolvimento do turismo. Além do estudo de referencial bibliográfico e de dados secundários, houve a participação em eventos relacionados ao tema e a realização de entrevistas semiestruturadas com representantes que vêm discutindo a proposta curricular e seu impacto no território. O estudo indica que o processo que está sendo proposto por meio da educação diferenciada pode contribuir para a organização do turismo de base comunitária, centrado em questões como autonomia e pertencimento.

Abstract The schools of caiçaras communities in “Praia do sono” and “Pouso da Cajaíba”, located in Paraty (RJ), initiated in 2016 to offer middle school education with the purpose of an education adapted to their realities. This initiative happens in a period when the communities are seeking new ways to develop tourism. The present article aims to discuss the construction process of the differentiated school education and its contribution to the development of tourism. In addition to the research of bibliographic references and secondary data, there was participation in events related to the theme and the implementation completion/execution of semi-structured interviews with representatives that have been discussing the curricular proposal and its impacts in the territory. The research shows that the process that is being proposed by means of the differentiated education can contribute to the organization of the community-based tourism, focused in questions such as autonomy and belonging.

Resumen Las escuelas de las comunidades caiçaras de “Praia do Sono” y “Pouso da Cajaíba”, situadas en el municipio de Paraty (RJ), comenzaron en el año 2016 la oferta de la enseñanza fundamental II con la propuesta de una educación adaptada a sus realidades. Esta iniciativa se produce en un periodo en que las comunidades vienen buscando nuevas formas de desarrollar el turismo. Además del estudio del referencial bibliográfico y datos secundarios, ha habido la participación en eventos relacionados a la temática y la realización de entrevistas semiestructuradas con representantes que ya vienen discutiendo la propuesta curricular y su impacto en territorio. La investigación indica que el proceso que se está propuesto por medio de la educación diferenciada puede contribuir a la organización del turismo de base comunitaria, centrado en cuestiones como autonomía y pertenencia.

An experimental study with an A356-AlSiMgFe alloy was developed to evaluate the microhardness performance in the microstructure resulting of an unsteady-state horizontal solidification process. The Al-7wt%Si-0.3wt%Mg-0.15wt%Fe alloy was elaborated and directionally solidified in a water-cooled horizontal solidification device. In order to experimentally determine the cooling and growth rates (VL and TR, respectively), a thermal analysis was also conducted during solidification. Microstructural characterization by optical microscopy, SEM/EDS elemental mapping and microanalysis of the punctual EDS compositions allowed to observe the presence of an Al-rich dendritic phase (Al(α)) with interdendritic phases second composed of an eutectic mixture: Al(α-eutectic) + Si + Al8Mg3FeSi6(π) + Mg2Si(θ). Furthermore, the dendritic microstructure was characterized by measuring the secondary dendritic spacings (λ2) along the horizontally solidified ingot. Higher HV values were observed within the eutectic mixture.

Gadodiamide (Gd-DTPA-BMA) is a gadolinium (Gd) chelate composed of two carboxylate groups of diethylenetriaminepentaacetic acid (DTPA) and two amide groups (BMA). Gd complexes are the most widely used contrast agents in nuclear magnetic resonance. Furthermore, our research group has demonstrated the potential of liposomes containing Gd-DTPA-BMA for cancer therapy. The aim of this study was to develop and validate a chemometric-assisted method by hydrophilic interaction liquid chromatography (HILIC) for determination of Gd-DTPA-BMA in liposomes. The chromatographic conditions obtained were: Sequant® ZIC®-HILIC Merck (150 × 4.6 mm, 3.5 µm, 100 Å) column, mobile phase composed of 5 mmol L-1 ACN/NH4FA, pH 4.5 (60:40 v/v) at 0.6 mL min-1, injection volume of 20 µL, temperature of 30 ºC, and detection at 210 nm. The linear range was of 40 to 120 nmol mL-1. The use of chemometrics allowed obtaining optimal chromatographic parameters, in terms of signal-to-noise ratio, resolution, and asymmetry.

Objetivo: Os quistos sinoviais da articulação acromioclavicular (AC), podem ocorrer associadas à artrose AC ou como consequência da rotura massiva da coifa dos rotadores. Com o presente caso, os autores pretendem apresentar e discutir uma situação pouco frequente. Relato de caso: Homem de 81 anos, referenciado à consulta de Ortopedia por tumefação da região superior do ombro direito, indolor e de aumento progressivo nos últimos 2 anos. Avaliação clínica e radiológica compatível com volumoso quisto sinovial da acromioclavicular, associado a rotura massiva da coifa dos rotadores; submetido a tratamento cirúrgico com excisão marginal da lesão; a análise anatomopatológica confirmou o diagnóstico de quisto sinovial. Comentários: Os quistos sinoviais da articulação AC são entidades raras e pouco abordadas na literatura. A sua etiologia permanece por esclarecer ainda que um dos tipos descritos pareça estar associada à omatrose com rotura massiva da coifa dos rotadores (artropatia da coifa); nestes, a rotura da coifa permite a passagem de grandes quantidades de líquido sinovial para o espaço subacromial com formação de um volumoso quisto. Atendendo à sua raridade, o tratamento permanece controverso. O caso vem alertar para a ocorrência dos quistos da articulação AC, como apresentação invulgar de artropatia das coifa dos rotadores, discutindo a sua etiologia e abordagem terapêutica adequada.

Objectives: Synovial cysts of the acromioclavicular (AC) usually occur in the setting of AC arthrosis, or more frequently, as a consequence of massive rotator cuff tears. With the following case report, the authors pretend to presente and discuss an unusual situation. Case report: An 81-year-old male, presented to our outpatient clinic due to a non-traumatic, painless lump on the superior aspect of his right shoulder, with progressive enlargement in the last 2 years. Clinical examination and imagiologic assessment showed a large acromioclavicular joint cyst associated with a massive rotator cuff tear; the patient was submitted to surgical treatment with excision of the lesion; anatomopathological exams confirmed the diagnosis of joint cyst. Discussion: AC joint cysts are rare and sparsely discussed in the literature. Their etiology remains to be clarified, although, one of the types described is thought to be associated with glenoumeral arthrosis with massive rotator cuff tears (cuff arthropathy). In these, the rotator cuff tear allows the passage of large amounts of synovial fluid to the subacromial space, leading the formation of a large cyst. Treatment remains controversial given its rarity. The case should raise awareness for the occurrence of AC synovial cysts as unusual presentations of rotator cuff arthropathy, discussing their etiology, diagnostic and therapeutic approach.

Aluminum alloys of the ANSI series 319 present Si and Cu as the main alloying elements and the mechanical strength of these alloys can be improved by the precipitation of the metastable Al2Cu phase during the ageing heat treatment. In this paper, the Al-5.5wt.%Si-3wt.%Cu alloy was elaborated and solidified in a water-cooled horizontal directional solidification device. The as-cast ingot was subjected to the precipitation hardening heat treatment (T6 heat treatment), which consisted of: solution for 5 h at 490°C±2°C, followed by quenching in water at 60°C±2°C and ageing for 3 h at 155°C±2°C, and cooling-air. Secondary dendrite arm spacing (λ2) measurements were carried out before and after T6 heat treatment. The mechanical strength of the alloy was investigated by the microhardness test. It has been found that the heat treatment did not influence the λ2 values, however, highest HV values have been observed for the heat-treated samples.