Objective: The ICD-11 Trauma Questionnaire (ITQ) was developed as a joint effort by researchers from several countries to evaluate post-traumatic stress (PTSD) and complex-PTSD (C-PTSD) symptoms. This study is part of a multi-center international collaborative research project that aims to provide psychometric support for this initial instrument in different languages, considering the specific contexts related to complex traumatization. This study verified the psychometric characteristics of the Portuguese version of the ITQ, evaluating symptoms beyond those described the existing literature. Methods: We examined the results of a convenience sample totaling 268 Portuguese and Angolan participants. Two instruments were applied: the ITQ, which evaluates symptoms resulting from a traumatic life event, and the Life Events Checklist (LEC), which evaluates stressful life events. The general characteristics of the scales are described, and reliability analysis and validity studies were performed. Results: Cronbach’s alpha varied between 0.84 and 0.88, and the exploratory factorial analysis results were consistent with the concept of C-PTSD, with five components explaining 61.58% of scale variance. Conclusion: The results suggest good psychometric characteristics for the Portuguese version of the ITQ, and thus it can be included in protocols intended evaluating complex traumatic symptoms.

Abstract Silver complexes containing 1,10-phenanthroline as a coordinated ligand have been of great interest due to their antibacterial and antifungal pharmacological properties. In this paper, we describe the synthesis of a new partial inclusion complex of bis(1,10-phenanthroline)silver(I) salicylate in β-cyclodextrin (β-CD) which was synthesized with a good yield. The compounds were characterized by FTIR, 1H, 13C NMR including 1H−1H COSY, TGA/DSC, elemental analysis (CHN), and X-ray powder diffraction. The results suggest the presence of non-covalent interactions such as hydrogen bonds, van der Waals forces, and hydrophobic interactions in the formation of the partial inclusion compound between β-CD and bis(1,10-phenanthroline)silver(I) salicylate [Ag(phen)2]salH. Additionally, an in silico prediction of 1,10-phenanthroline biological activities was carried out and the acquired data suggests several potential targets associated with the antimicrobial activity of this compound and its silver complex. Most predicted targets are related to antimicrobial virulence and resistance that are a serious threat to global public health. The inclusion compound showed a higher inhibiting growth of Candida albicans than the free complex [Ag(phen)2]salH indicating that the formation of the inclusion complex with β-CD increases the bioavailability of the antimicrobial active species [Ag(phen)2]+ of the new silver(I) compound.

Resumo O rápido desenvolvimento e disseminação das tecnologias de informação nas últimas décadas permitiu uma grande expansão na oferta de cursos de graduação e pós- -graduação na modalidade a distância. Contudo, essa disseminação foi acompanhada por elevadas taxas de evasão, consistentemente reportadas em diferentes cursos e em diferentes países. Essa também é a realidade da educação a distância no Brasil: uma grande expansão, inclusive com a criação da Universidade Aberta do Brasil, porém com elevadas taxas de insucesso. Este estudo avaliou a evasão e suas causas em um curso de pós-graduação lato sensu do Programa Nacional de Formação em Administração Pública (PNAP), que visa formar gestores públicos no interior do Brasil. A elevada taxa de insucesso nesses cursos causa um entrave para que se atinjam os objetivos do programa, pois impede a formação de mão de obra justamente onde ela é mais necessária. Este artigo investiga os principais fatores que levam a esse fenômeno, por meio de análise documental e coleta de dados de alunos da Universidade Federal da Grande Dourados, no estado do Mato Grosso do Sul, via survey. Após a coleta, feita por meio da aplicação de questionários e entrevistas, procedeu-se a uma análise estatística dos dados que revelou um perfil de aluno da pós-graduação condizente com o reportado na literatura e propício à evasão. Verifica-se que, dado esse perfil de aluno, são necessárias algumas estratégias administrativas para que a evasão não seja tão elevada. As estratégias notoriamente não são suficientes para trazer a taxa de evasão a níveis aceitáveis, por outro lado, não desenvolvê-las garante sua não diminuição.

Abstract The rapid development and dissemination of information technologies in the last decades has allowed a great expansion in the offer of undergraduate and graduate distance programs. However, this dissemination has been accompanied by high dropout rates, consistently reported in different programs and countries. This is the reality of distance education in Brazil too: a great expansion, including the establishment of Universidade Aberta do Brasil (UAB - Open University of Brazil), but with high failure rates. This study evaluated school dropout and its causes in a graduate certificate program of Programa Nacional de Formação em Administração Pública (PNAP - National Training Program in Public Administration), which aims to train public administrators in the interior of Brazil. High failure rates in these programs have been an obstacle to achieving the objectives of PNAP, because they prevent the training of labor precisely where it is most needed. This article investigates the main factors that lead to this phenomenon, by means of documentary analysis and collection of data on students from Universidade Federal da Grande Dourados, in Mato Grosso do Sul state, Brazil, via survey. After the collection, conducted through questionnaires and interviews, we did a statistical analysis of the data, which revealed a graduate student profile consistent with that reported in the literature and conducive to school dropout. It is verified that, given this student profile, some administrative strategies are necessary to prevent dropout rates from being so high. Such strategies are notoriously not enough to reduce dropout rates to acceptable levels; on the other hand, not developing strategies ensures dropout rates will not decrease.

ABSTRACT PURPOSE: To analyze the healing effects of stromal vascular fraction (SVF) application compared to wound dressing with 2% silver sulfadiazine in full thickness burn wounds in rats. METHODS: Animals were divided into two groups: 2% silver sulfadiazine group and SVF group. Both groups received occlusive bandages while the first one was treated with 2% silver sulfadiazine and the latter was treated with injections of SVF prepared from adipose tissue extracted from an animal donor. The animals were accompanied through 3, 7 and 30 days for evaluation of macroscopic, microscopic and morphometric aspects. RESULTS: On day three, a significant increase (p<0.05) of infiltration of polymorphonuclear, fibrin formation and fibroblasts migration in SVF group was observed. On the 7th day the mononuclear infiltrate, angiogenesis, collagen and fibroblasts were significantly increased in the SVF group (p<0.05). At 30 days significantly increased collagen deposition was observed in the SVF group (p<0.05) . CONCLUSION: Adipose tissue derived stromal vascular fraction injections promotes better wound repair than 2% silver sulfadiazine in the treatment of full thickness burn in rats during the evaluated experimental period.

ABSTRACT Myracrodruon urundeuva Allemão, Anacardiaceae, is a medicinal plant widely found in Brazil, especially in the northern region. In our previous study, the ethanolic extract from leaves of M. urundeuva showed antiviral activity against simian rotavirus SA-11. Here, the crude extract was subjected to fractionations in order to subsequently work with more concentrated and pure bioactive compounds, which were analyzed by TLC and HPLC methods to support a better understanding of their virucidal effect. The antiviral activity was evaluated using a rotavirus infection model in MA-104 cells treated with the maximum non-cytotoxic concentration of the crude extract and its fractions. Data were expressed as the percentage inhibition of viral replication calculated by the inhibition of cytopathic effect in the treated cells compared to untreated controls after 48 h of incubation. First, we conducted a fractionation, generating five fractions (F1–F5) which were submitted to antiviral assay. Then, the fraction that showed the highest virucidal effect (F3, PI = 75%) was subjected to a larger partition, yielding eighteen subfractions, which were submitted to new antiviral assays. Terpenes, flavonoids and tannins were the major secondary metabolites detected by TLC analysis in F3. SF1, a flavonoid-enriched fraction, showed the strongest in vitro activity against rotavirus (PI = 92%), preventing cytopathic effect. Chromatographic profiles were obtained by HPLC for the crude extract and SF1, the most potent subfraction. Overall, our data point to the potential anti-rotavirus activity of flavonoid-enriched fraction (SF1) of M. urundeuva leaves, corroborating the traditional use of this species to treat diarrhea and broadening our perspectives on in vivo assays in mice with SF1 isolated or associated with other fractions.

In this work, the risk factors associated with overweight in adolescents are supported, with emphasis in the process of alimentary hybridization. Also, it is analyzed and it is meditated on the existent relationship between health and society; decisive factors of the health in the society. Different approaches assumed by sociologists and sanitary professionals that favour the appropriation of a logic in the scientific thought, are defined, contributing to a classification of the alimentary practices which characterize the hybridization processes in Ecuadorian adolescents, starting from the postulates of the health sociology

En este trabajo se fundamentan los factores de riesgos asociados al sobrepeso en adolescentes, con énfasis en el proceso de hibridación alimentaria. Asimismo, se analiza y se reflexiona sobre la relación existente entre salud y sociedad; factores determinantes de la salud en la sociedad. Se definen diferentes criterios asumidos por sociólogos y profesionales sanitarios, que favorecen la apropiación de una lógica en el pensamiento científico, contribuyendo a una clasificación de las prácticas alimentarias que caracterizan los procesos de hibridación en adolescentes ecuatorianos, a partir de los postulados de la sociología de la salud

In this investigation, the process of primary care in the public health system of Ecuador is consolidated, from the epistemological point of view, specifically in the province of Guayas, with emphasis in the process of traditional and alternative therapies in the health care, related to the official biomedical system of comprehensive health, with holistic, family, community and interculture approach, based on the respect to the ethnic particularities and peculiarities. Different approaches and criteria assumed by the health professionals are defined, which favor the appropriation of a logic in the scientific thought, that contributes to the psychoneuroinmunoendocrinological balance that reaches the ally kawsay or good living of the Ecuatorian population

En esta investigación se fundamenta, desde el punto de vista epistemológico, el proceso de atención primaria en el sistema de salud pública en Ecuador, específicamente en la provincia del Guayas, con énfasis en el proceso de terapias tradicionales y alternativas en la atención sanitaria, relacionado con el sistema biomédico oficial de salud integral, con enfoque holístico, familiar, comunitario e intercultural, basado en el respeto a las particularidades y peculiaridades étnicas. Se definen diferentes criterios y enfoques asumidos por los profesionales de la salud, que favorecen la apropiación de una lógica en el pensamiento científico, lo cual contribuye al equilibrio psiconeuroinmunoendocrinológico, que alcanza el ally kawsay o buen vivir de la población ecuatoriana

Imide compounds have shown biological activity. These compounds can be easily synthesized with good yields. The objective of this paper was the rational planning of imides and sulfonamides with antinociceptive activity using the 3D-QSAR/CoMFA approach. The studies were performed using two data sets. The first set consisted of 39 cyclic imides while the second set consisted of 39 imides and 15 sulfonamides. The 3D- QSAR/CoMFA models have shown that the steric effect is important for the antinociceptive activity of imide and sulphonamide compounds. Ten new compounds with improved potential antinociceptive activity have been proposed by de novo design leapfrog simulations.

This paper describes 2D-QSAR and 3D-QSAR studies against Candida albicans and Cryptococcus neofarmans for a set of 20 bisbenzamidines. In the studies of 2D-QSAR with C. albicans it was obtained a correlation between log MIC-1 and lipolo component-Z (r² = 0.68; Q² = 0.51). In the case of C. neofarmans a correlation between log MIC-1 and lipolo component-Z and of Balaban index (r² = 0.85; Q² = 0.6) was obtained. 3D-QSAR studies using CoMFA showed that the steric fields contributed more to the predicted activities for Candida albicans (94.9%) and Cryptococcus neofarmans (97.9%).

The chemotherapy agents against cancer may be classified as "cell cycle-specific" or "cell cycle-nonspecific". Nevertheless, several of them have their biological activity related to any kind of action on DNA such as: antimetabolic agents (DNA synthesis inhibition), inherently reactive agents (DNA alkylating electrophilic traps for macromolecular nucleophiles from DNA through inter-strand cross-linking - ISC - alkylation) and intercalating agents (drug-DNA interactions inherent to the binding made due to the agent penetration in to the minor groove of the double helix). The earliest and perhaps most extensively studied and most heavily employed clinical anticancer agents in use today are the DNA inter-strand cross-linking agents.

The aim of this work is to study the conservation laws of continuous means mechanics and also to extend the Hamiltonian method for these kind of systems in order to valid for non-potential operators through variational approach. Besides illustrating with various examples of mechanical applications we also introduce in this work the new technique in order to treat such problems as the non-potential problem.

O Nordeste do Brasil - em particular, o estado do Ceará - está colocado diante de um quadro de profundas modificações territoriais, demográficas, econômicas e sociais conduzidas pelo movimento transnacional de globalização e de reestruturação produtiva, que pode, dependendo da forma como for conduzido, trazer sérios impactos sobre a qualidade de vida da população, comprometendo a perspectiva de avanço para uma sociedade sustentável. Em tal contexto, a Universidade Federal do Ceará implantou o Curso de Especialização em Saúde, Trabalho e Meio Ambiente para o Desenvolvimento Sustentável na tentativa de cumprir sua função social, capacitando atores sociais para intervirem neste processo. O Curso oferece, como características inovadoras, a definição de um campo temático abrangente e complexo - relações entre saúde, trabalho e meio ambiente -, um corpo discente eminentemente multiprofissional e a busca permanente da construção de metodologia de ensino-aprendizagem que contemple a abordagem interdisciplinar do objeto. O artigo apresenta o Programa do Curso, dividido em quatro módulos e suas disciplinas; descreve as estratégias que têm sido adotadas na prática da interdisciplinaridade; avalia as dificuldades encontradas; e exemplifica como está sendo organizada a produção acadêmica.

Northeastern Brazil, in particular the State of Ceará, is currently undergoing profound territorial, demographic, economic and social changes brought about the transnational movement of Globalization and Productive Restructuring. This movement may, depending on how it is dealt with, produce a serious impact on the general life quality and thus compromise the perspective of a sustainable society in the future. The Federal University of Ceará, wishing to fulfill its social function in this process, has implanted a Specialization Course in Health, Work and Environment for Sustainable Development to prepare professionals in these areas. The Course inovates by presenting a broad and complex thematic scope (the interrelations between health, work and environment), an eminently multiprofessional group of participants, and an attempt at building up a teaching-and-learning methodology with a neatly interdisciplinarity approach. This article also presents the course program, divided in four parts and disciplines. The strategies used in the practice of interdisiciplinarity are described, the difficulties are assessed and the organization of the academic production is shown.

O Nordeste do Brasil - em particular, o estado do Ceará - está colocado diante de um quadro de profundas modificações territoriais, demográficas, econômicas e sociais conduzidas pelo movimento transnacional de globalização e de reestruturação produtiva, que pode, dependendo da forma como for conduzido, trazer sérios impactos sobre a qualidade de vida da população, comprometendo a perspectiva de avanço para uma sociedade sustentável. Em tal contexto, a Universidade Federal do Ceará implantou o Curso de Especialização em Saúde, Trabalho e Meio Ambiente para o Desenvolvimento Sustentável na tentativa de cumprir sua função social, capacitando atores sociais para intervirem neste processo. O Curso oferece, como características inovadoras, a definição de um campo temático abrangente e complexo - relações entre saúde, trabalho e meio ambiente -, um corpo discente eminentemente multiprofissional e a busca permanente da construção de metodologia de ensino-aprendizagem que contemple a abordagem interdisciplinar do objeto. O artigo apresenta o Programa do Curso, dividido em quatro módulos e suas disciplinas; descreve as estratégias que têm sido adotadas na prática da interdisciplinaridade; avalia as dificuldades encontradas; e exemplifica como está sendo organizada a produção acadêmica.

Northeastern Brazil, in particular the State of Ceará, is currently undergoing profound territorial, demographic, economic and social changes brought about the transnational movement of Globalization and Productive Restructuring. This movement may, depending on how it is dealt with, produce a serious impact on the general life quality and thus compromise the perspective of a sustainable society in the future. The Federal University of Ceará, wishing to fulfill its social function in this process, has implanted a Specialization Course in Health, Work and Environment for Sustainable Development to prepare professionals in these areas. The Course inovates by presenting a broad and complex thematic scope (the interrelations between health, work and environment), an eminently multiprofessional group of participants, and an attempt at building up a teaching-and-learning methodology with a neatly interdisciplinarity approach. This article also presents the course program, divided in four parts and disciplines. The strategies used in the practice of interdisiciplinarity are described, the difficulties are assessed and the organization of the academic production is shown.

Hoplosternum Uttorale (Hancock, 1828) is an abundant species in the lagoons of the upper Paraná river floodplain. This species was sampled in Patos and Guaraná lagoons in the flood period (November/92-May/93) and low water period (June-October/93). To analyse food contents in the diet were analysed stomach of 91 adults. Twenty seven food items were recorded, among them, Testaceae, Nematoda, microcrustaceans, quironomids and organic detritus were predominant. These items allows to characterize the species as bentivore. To study feeding activity were analized 565 adults stomach contents. Food intake was more intense during flooding. Considering diel variation, the species started to eat during dusk, increasing during night, stopping to eat during daytime.

A Enfermagem, nos programas de extensão universitária, resume uma das linhas de trabalho do Curso de Enfermagem para os anos de 1980/1983. Desenvolver-se-á em dois grandes projetos: "ENFERMAGEM NA ATENÇÃO PRIMÁRIA" e "ENFERMAGEM NA EDUCAÇÃO PARA A SAÚDE". Pretende-se utilizar uma estratégia que, de forma assistemática, já vinha sendo desenvolvida nos semestres anteriores nas disciplinas relacionadas à Saúde Pública. O propósito é a utilização do escolar como elemento integrador dos recursos básicos da comunidade, como escola-família-unidade sanitária. Fundamentando-se no Art. 7.° da Lei n.° 5.692/71, desenvolver-se-ão atividades que possibilitarão o acesso de estudantes de Enfermagem à escola de 1.° grau. Entende-se que à escola compete formar o cidadão que emergirá da criança de hoje. Um cidadão cônscio de seus direitos e deveres, co-responsável na ação de desenvolvimento comunitário. Nesse sentido, pretende-se habilitar o escolar a participar, consciente e voluntariamente, das ações de saúde, como: notificação de nascimentos, óbitos, presença de gestantes na sua vizinhança, assim como das puérperas, crianças sem imunizações e ainda a presença de casos suspeitos de doenças transmissíveis.O trabalho apresenta a estratégia, o programa de treinamento para os professores das séries iniciais do 1.° grau, perspectivas para uma integração docente-assistencial a nível de extensão das ações de saúde.