There is a widely acknowledged gap between research, policy, and practice owing to a lack of capacity to translate and mobilise research results to end-users including policymakers, practitioners, and community members. Acknowledging the divide amongst researchers, policymakers, and practitioners, this conceptual paper seeks to address the following: How do we devise ways to strengthen the research-policy-practice nexus in the education landscape such that research institutions can better attend to the needs of policymakers and practitioners? How can we facilitate greater interaction among researchers, policymakers, practitioners, and other stakeholders to create a common understanding of the challenges, needs, and what works for all stakeholders? To do this, we propose a new approach that employs research as a mechanism for social change and uses the consciousness of the self as a resource for research. More specifically, we develop a framework that facilitates the conditions for the mutual understanding of norms, operational roles, academic rigour, and policy and practice outcomes among all stakeholders. Additionally, this framework seeks to foster increased inter-stakeholder conversations and dialogues to narrow the divide between researchers and policymakers and, correspondingly, improve policy translations from academic research.

Abstract The higher acidity in fruits compared with grapes was one of the main obstacles to producing high-quality fruit wines. In the present research, the effect of the split batch fermentation pattern on the metabolites of greengage wines was investigated. This fermentation pattern included whole fruit immersion in the sucrose and coculturing Saccharomyces bayanus Y4 with Torulaspora delbrueckii Y7. These results showed that the contents of total acidity and dominant organic acids were significantly reduced among the batches. Aliphatic compounds were decreased with the batches, while aromatic compounds that contributed to flavor improvement were increased oppositely. The acetate esters, ketones, and terpenes contents were significantly increased in the first batch of coculture. In addition, acidic stress largely affected the kinetics characteristics of greengage wine on a pilot scale. Interestingly, the increment of total acidity was closely associated with the rate of total sugar consumption, which was affected by microbial activities. The acidity content was significantly declined and distinct flavour profiles were formed in split batch and coculture fermentation of greengage wines. It provides a new avenue to enhance the flavor and quality of fruit wines. highquality high research investigated Y Y7 batches oppositely esters ketones addition scale Interestingly consumption activities

ABSTRACT: The purpose of this paper is to construct a new general vehicle model as an open fundamental material for the guidance and control research. In this study, parameterized configuration, aerodynamics calculation, control-oriented modeling, stability analysis, and nominal trajectory design are performed for the general vehicle model. First, the aerodynamic configuration is parameterized as an axisymmetric body with a power-law revolution nose. Then, an engineering method considering inviscid flow, base drag and skin friction is used for the aerodynamics calculation, and a control-oriented fitting model of longitudinal aerodynamics is established based on the analysis of the correlation between aerodynamic force and the parameters of Mach number, attack angle, elevator deflection and height. Next, the aerothermodynamic environment prediction of power-law revolution axisymmetric hypersonic vehicle (PRAHV) is discussed, and the nose heating rate formula of PRAHV is established. The stability analysis and nominal trajectory design of PRAHV is performed based on the fitting model and the heating rate formula. The stability analysis shows that both the static stability and dynamic stability of the vehicle are unstable. The nominal trajectory of unpowered longitudinal maneuvering is achieved by the hp-adaptive pseudospectral method, which demonstrated that the availability of the control-oriented model established in this paper. In conclusion, this work provides a fundamental object for further study of vehicle guidance, control, and evaluation.

ABSTRACT: Poor lateral-directional stability due to the absence of vertical stabilizer is a great risk to the aircraft with flying wing layout. In this paper, an unmanned aerial vehicle with this kind of configuration is chosen as the research object. A three-dimensional model of the unmanned aerial vehicle is established, and then the sensitivity analysis is performed to obtain the effects of main aerodynamic shape parameters on lateral-directional flying quality. The results show that the roll mode and spiral mode of the aircraft meet the requirements of Level 1 flying quality in MIL-F-8785C. But the Dutch roll mode is generally divergent, which means that the flying quality of the aircraft is unacceptable. Thus it can be seen that the Dutch roll mode is the key to the dynamic stability of the aircraft. Further studies show that increasing the value of wing aspect ratio or decreasing the values of dihedral angle and torsion angle are useful for improving the Dutch roll mode. It is valuable to reveal the influence mechanism of aerodynamic shape parameters on lateral-directional flying quality for the design of flying wing aircraft.

Monoclonal gammopathy of renal significance (MGRS) can present with different morphologic features and lead to kidney failure. The Henoch-Schönlein purpura nephritis (HSPN) that cannot be relieved by treatment with glucocorticoid and immunosuppressive agents suggests the presence of monoclonal gammopathy in adult patients. The present study reports on a single case of HSPN associated with IgA-κMGRS. The patient who suffered from recurrent skin purpura for 6 months and nephrotic syndrome for 2 months was admitted to our hospital. Bone marrow biopsy showed monoclonal gammopathy of undetermined significance. Kidney biopsy indicated a Henoch-Schönlein purpura nephritis (HSPN, ISKDC classified as type III) with positive staining with κ-light chain in the glomeruli and renal tubular epithelial cells. Furthermore, skin biopsy showed leukocytoclastic vasculitis and negative staining for Congo red and light chain. Given both the renal and cutaneous involvement, the patient was considered to have HSPN associated with IgA-κMGRS. The patient experienced an exacerbation in his purpura-like lesions and clinical status after treatment with glucocorticoid and immunosuppressive agents. Consequently, the patient was put on a regimen that included dexamethasone (20 mg on the 1st, 4th, 8th, and 11th days of each month, iv) and bortezomib (2.4 mg on the 1st, 4th, 8th, and 11th days of each month, iv). Eight weeks after treatment, he had complete resolution of his cutaneous purpura and his biochemical parameters improved. The latent presence of MGRS in cases of HSPN should be considered in adult patients. Increased cognizance and correct treatment options could improve patient outcomes.

Abstract White pepper (Piper nigrum L.) and long pepper (Piper longum L.) belong to family Piperaceae and are commonly used as household spices and traditional medicine worldwide, specifically in China and Southeast Asia. In Traditional Chinese Hui Medicine, these herbs are widely used for treatment of stroke. Our present study investigated effects of these herbs on inflammation in rat model with cerebral ischemia. After subjecting the rats to permanent middle cerebral artery occlusion (pMCAO) for 6 h, at doses of 100 and 200 mg/kg, dichloromethane fraction from white pepper and long pepper, respectively, was intragastrically administered once a day for seven consecutive days. Cerebral cortical and hippocampal tissues were collected after seven days. Superoxide dismutase, malonaldehyde, tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and IL-6 were measured by spectrophotometer. Phytochemical profile of dichloromethane fraction was determined through HPLC. Dichloromethane fraction exhibited anti-inflammatory activity by suppressing expression or production of IL-1β, IL-6, and TNF-α. By contrast, dichloromethane fraction showed activity against pMCAO injury by reducing oxygen-free radicals through increased superoxide dismutase activity and decreased malonaldehyde level. HPLC analysis revealed piperine as major component of dichloromethane fraction. These results show that dichloromethane fraction provides protection against cerebral ischemia. The possible mechanism is related to anti-inflammatory activity and reduction in oxygen-free radicals.

Abstract A new 3-node triangular hybrid displacement function Mindlin-Reissner plate element is developed. Firstly, the modified variational functional of complementary energy for Mindlin-Reissner plate, which is eventually expressed by a so-called displacement function F, is proposed. Secondly, the locking-free formulae of Timoshenko’s beam theory are chosen as the deflection, rotation, and shear strain along each element boundary. Thirdly, seven fundamental analytical solutions of the displacement function F are selected as the trial functions for the assumed resultant fields, so that the assumed resultant fields satisfy all governing equations in advance. Finally, the element stiffness matrix of the new element, denoted by HDF-P3-7β, is derived from the modified principle of complementary energy. Together with the diagonal inertia matrix of the 3-node triangular isoparametric element, the proposed element is also successfully generalized to the free vibration problems. Numerical results show that the proposed element exhibits overall remarkable performance in all benchmark problems, especially in the free vibration analyses.

ABSTRACT: An optimization strategy is constructed to solve the aerodynamic and structural optimization problems in the conceptual design of double-swept flying wing aircraft. Aircraft preliminary aerodynamic and structural design optimization is typically based on the application of a deterministic approach of optimizing aerodynamic performance and structural weight. In aerodynamic optimization, the objective is to minimize induced drag coefficient, and the structural optimization aims to find the minimization of the structural weight. In order to deal with the multiple objective optimization problems, an optimization strategy based on collaborative optimization is adopted. Based on the optimization strategy, the optimization process is divided into system level optimization and subsystem level optimization. The system level optimization aims to obtain the optimized design which meets the constraints of all disciplines. In subsystem optimization, the optimization process for different disciplines can be executed simultaneously to search for the consistent schemes. A double-swept configuration of flying wing aircraft is optimized through the suggested optimization strategy, and the optimization results demonstrate the effectiveness of the method.

ABSTRACT The genus Aconitum has strong toxicity, but the acute toxicity of baked Aconitum flavum Hand.-Mazz., Ranunculaceae, was reduced significantly on the premise of keeping anti-inflammatory and anti-nociceptive activities. However, the risk associated with long-term use is unknown. In a sub-chronic toxicity study, rats were orally administered A. flavum at doses of 0.76–3.03 g/kg for 90 days and further recovered for 14 days. Our results showed that oral treatment with A. flavum for 90 days caused significant changes in some hematological indicators at doses of 3.03 and 1.52 g/kg, such as red blood cell, hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration. These results indicated that the A. flavum affects the structure and function of red blood cell. Furthermore, significant changes were observed in the white blood cell at dose of 3.03 g/kg in male rats, which confirmed tissue damage or toxicity. The liver function tests exhibited non-significant alterations in aspertate aminotransferase, alanine aminotransferase and avenin-like storage proteinsgene. But other parameters, such as total protein and albumin were obviously decreased at all doses. A. flavum also caused a significant decrease in glucose, cholesterol and triacylglyceride at all doses. For kidney function, there were significant elevations in urea and creatinine at doses of 3.03 and 1.52 g/kg. The levels of certain electrolytes (Na+, K+ and Cl-) were significantly different after 90 days of treatment with A. flavum (3.03 and 1.52 g/kg). Organs were observed by light microscopy after hematoxylin-eosin staining. Hemosiderin depositions in the spleen were observed in the A. flavum group. These data demonstrated that the subtoxicity of A. flavum was reduced considerably by baked, but the subchronic toxicity effects on the liver, kidney and spleen should not be ignored.

The porous fluorescent SiO2 nanoparticles encapsulating photosensitizer Ru(bpy)3Cl2were prepared by Stöber method and used as a carrier to immobilize glucose oxidase (GOD) to form the bifunctional porous SiO2 complex nanoparticles (BPSCNp) with the properties of enzymatic catalysis and optical oxygen sensing. The optimal immobilization conditions are as follows: hexadecyltrimethyl ammonium bromide (APTES) concentration of 2% (v/v), glutaraldehyde (GA) concentration of 1.0% (v/v), and pH of 6.5, GOD amount of 4.0 mg in 40 mg of carrier. BPSCNp showed maximal catalytic activity at pH 6.0 and 50 °C. After immobilization, the thermal storage and operation stability of GOD were improved remarkably. After kept at 4 °C for 30 days, BPSCNp and free GOD retained 68% and 35% of initial activity, respectively. BPSCNp maintained 58% of its initial activity after 7 consecutive operations and 30% after 15 consecutive operations. The fluorescence of BPSCNp could be quenched effectively by oxygen. There was a good linear relationship between tanΦ0/tanφ and O2 concentration in the range of 0 to ca. 90%. BPSCNp had a highly reproducible response to oxygen with the response time of 20 s. BPSCNp might be used as the sensing material and have potential application in multi parameter fiber optic biosensor based on enzyme catalysis and oxygen consumption.